scholarly journals Coexistence of gastrointestinal stromal tumours (GIST) and malignant neoplasms of different origin: Prognostic implications

2014 ◽  
Vol 12 (5) ◽  
pp. 371-377 ◽  
Author(s):  
Nikolaos Vassos ◽  
Abbas Agaimy ◽  
Werner Hohenberger ◽  
Roland S. Croner
Keyword(s):  
Malignant Neoplasms ◽  
Gastrointestinal Stromal Tumours ◽  
Prognostic Implications ◽  
Different Origin

Gene of the month: SDH

2017 ◽  
Vol 71 (2) ◽  
pp. 95-97 ◽  
Author(s):  
Alessandro Pietro Aldera ◽  
Dhirendra Govender
Keyword(s):  
Citric Acid Cycle ◽  
Mitochondrial Protein ◽  
Leigh Syndrome ◽  
Molecular Therapy ◽  
Wild Type ◽  
Gastrointestinal Stromal Tumours ◽  
Prognostic Implications ◽  
Novel Target ◽  
And Function ◽  
Transfer Chain

Succinate dehydrogenase (SDH) is a heterotetrameric nuclear encoded mitochondrial protein complex which plays a role in the citric acid cycle and the electron transfer chain. Germline mutations in SDHA are associated with Leigh syndrome. Mutations in SDHB, SDHC and SDHD are found in an increasing number of neoplasms, most notably paragangliomas and wild-type gastrointestinal stromal tumours. SDH deficiency in these tumours has important prognostic implications, and also provides a novel target for molecular therapy. In this article, we outline the structure and function of SDH and provide a summary of its role in various diseases.

Primary Malignant Neoplasms of the Duodenum. Excluding the Papilla of Vater

1956 ◽  
Vol 30 (3) ◽  
pp. 421-431 ◽  
Author(s):  
Arthur Burgerman ◽  
Archie H. Baggenstoss ◽  
James C. Cain
Keyword(s):  
Malignant Neoplasms ◽  
Papilla Of Vater
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