Atypical presentation and location of two gastrointestinal stromal tumours: Prognostic implications

2016 ◽  
Author(s):  
Helder Moreira
Keyword(s):  
Atypical Presentation ◽  
Gastrointestinal Stromal Tumours ◽  
Prognostic Implications

scholarly journals ATYPICAL PRESENTATION OF GASTROINTESTINAL STROMAL TUMOURS WITH PNEUMOPERITONEUM: A CASE REPORT

2016 ◽  
Vol 5 (37) ◽  
pp. 2256-2259
Author(s):  
Soundara Pandiyan Ramakrishnan ◽  
Manikannan Subramaniyan ◽  
Ramesh Arunachalam ◽  
Selva Sankar Sankaranarayanan
Keyword(s):  
Case Report ◽  
Atypical Presentation ◽  
Gastrointestinal Stromal Tumours

Gene of the month: SDH

2017 ◽  
Vol 71 (2) ◽  
pp. 95-97 ◽  
Author(s):  
Alessandro Pietro Aldera ◽  
Dhirendra Govender
Keyword(s):  
Citric Acid Cycle ◽  
Mitochondrial Protein ◽  
Leigh Syndrome ◽  
Molecular Therapy ◽  
Wild Type ◽  
Gastrointestinal Stromal Tumours ◽  
Prognostic Implications ◽  
Novel Target ◽  
And Function ◽  
Transfer Chain

Succinate dehydrogenase (SDH) is a heterotetrameric nuclear encoded mitochondrial protein complex which plays a role in the citric acid cycle and the electron transfer chain. Germline mutations in SDHA are associated with Leigh syndrome. Mutations in SDHB, SDHC and SDHD are found in an increasing number of neoplasms, most notably paragangliomas and wild-type gastrointestinal stromal tumours. SDH deficiency in these tumours has important prognostic implications, and also provides a novel target for molecular therapy. In this article, we outline the structure and function of SDH and provide a summary of its role in various diseases.

scholarly journals An Atypical Presentation of Lichen Planus-Like Reaction from Pembrolizumab

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Matthew Lee ◽  
Nagashree Seetharamu
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Side Effects ◽  
Lichen Planus ◽  
Lung Cancer Patient ◽  
Topical Steroids ◽  
Atypical Presentation ◽  
Cutaneous Side Effects ◽  
Organ Systems ◽  
Prognostic Implications

Introduction. With the advent of immunotherapy, a new subtype of side effects called IRAEs or immune related adverse effects have become more common. They may present in various organ systems as colitis, pneumonitis, hypophysitis, and thyroiditis and commonly as dermatological reactions. Case. This is a case report of a lung cancer patient that was started on Pembrolizumab and developed shortly after what appeared to be clinically at first pustular psoriasis but on biopsy was confirmed to be lichen planus. She was discontinued on the Pembrolizumab and treated with both systemic and topical steroids and improved. Conclusion. This case highlights a cutaneous reaction from Pembrolizumab and the subsequent management that helped resolve her condition but also weighing the benefits against the risk of treatments and potential prognostic implications of having cutaneous side effects.

scholarly journals Atypical Presentation of Gastrointestinal Stromal Tumours—A Case Report

2012 ◽  
Vol 75 (S1) ◽  
pp. 185-187
Author(s):  
Kalpana Raja ◽  
Bhawna Dev ◽  
Roy Santosham ◽  
Joseph Santhosh
Keyword(s):  
Case Report ◽  
Atypical Presentation ◽  
Gastrointestinal Stromal Tumours
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