An oncogenetic tree model in gastrointestinal stromal tumours (GISTs) identifies different pathways of cytogenetic evolution with prognostic implications

2007 ◽  
Vol 211 (4) ◽  
pp. 463-470 ◽  
Author(s):  
B Gunawan ◽  
A von Heydebreck ◽  
B Sander ◽  
H-J Schulten ◽  
F Haller ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumours ◽  
Tree Model ◽  
Prognostic Implications ◽  
Cytogenetic Evolution

Gene of the month: SDH

2017 ◽  
Vol 71 (2) ◽  
pp. 95-97 ◽  
Author(s):  
Alessandro Pietro Aldera ◽  
Dhirendra Govender
Keyword(s):  
Citric Acid Cycle ◽  
Mitochondrial Protein ◽  
Leigh Syndrome ◽  
Molecular Therapy ◽  
Wild Type ◽  
Gastrointestinal Stromal Tumours ◽  
Prognostic Implications ◽  
Novel Target ◽  
And Function ◽  
Transfer Chain

Succinate dehydrogenase (SDH) is a heterotetrameric nuclear encoded mitochondrial protein complex which plays a role in the citric acid cycle and the electron transfer chain. Germline mutations in SDHA are associated with Leigh syndrome. Mutations in SDHB, SDHC and SDHD are found in an increasing number of neoplasms, most notably paragangliomas and wild-type gastrointestinal stromal tumours. SDH deficiency in these tumours has important prognostic implications, and also provides a novel target for molecular therapy. In this article, we outline the structure and function of SDH and provide a summary of its role in various diseases.

Efficacy and toxicity of glivec in the treatment of gastrointestinal stromal tumours

2006 ◽  
Vol 44 (05) ◽  
Author(s):  
K Tamas ◽  
Z Papai ◽  
E Vegh ◽  
Á Petrányi ◽  
Z Szucs ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumours
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