Response surface methodology and artificial neural network modeling for optimization of ultrasound-assisted extraction and rapid HPTLC analysis of asiaticoside from Centella asiatica

2022 ◽  
Vol 176 ◽  
pp. 114320
Author(s):  
Poonam Kumari ◽  
Prabhjot Kaur ◽  
Vijay Kumar ◽  
Babita Pandey ◽  
Romaan Nazir ◽  
...  
2014 ◽  
Vol 618 ◽  
pp. 367-375 ◽  
Author(s):  
Tao Guo ◽  
Jun Qing Wei ◽  
Ya Wang ◽  
Dan Su ◽  
Zhen Zhang ◽  
...  

In this study, Ultrasound-assisted extraction (UAE) was used for polysaccharides extraction from Potentilla anserina. A computer-stimulated artificial neural network (ANN) was developed to get a correlation between the input variables and the output parameter. Finally, the optimal process conditions were obtained as follows: extraction temperature 55 °C, extraction time 55 min, ratio of liquid to solid 20:1, power 175 W. Under optimized conditions, ultrasound-assisted extraction had obviously higher yield of polysaccharides than the traditional heat reflux method. The optimization procedure showed a close interaction between the experimental and simulated values for polysaccharides extraction. The R2 (0.99271) and MSE (0.0425) values of model suggested good fitness and generalization of the ANN. Moreover, the results also indicated that polysaccharides have inhibitory effect on ADP-induced platelet aggregation.


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