Influence of the induced membrane filled with syngeneic bone and regenerative cells on bone healing in a critical size defect model of the rat’s femur

Injury ◽  
2018 ◽  
Vol 49 (10) ◽  
pp. 1721-1731 ◽  
Author(s):  
Christoph Nau ◽  
Sebastian Simon ◽  
Alexander Schaible ◽  
Caroline Seebach ◽  
Katrin Schröder ◽  
...  
Keyword(s):  
Bone Healing ◽  
Critical Size ◽  
Defect Model ◽  
Critical Size Defect ◽  
Induced Membrane ◽  
Regenerative Cells

Validation of a Femoral Critical Size Defect Model for Orthotopic Evaluation of Bone Healing: A Biomechanical, Veterinary and Trauma Surgical Perspective

2008 ◽  
Vol 14 (1) ◽  
pp. 79-88 ◽  
Author(s):  
Inga Drosse ◽  
Elias Volkmer ◽  
Sebastian Seitz ◽  
Hermann Seitz ◽  
Rainer Penzkofer ◽  
...  
Keyword(s):  
Bone Healing ◽  
Critical Size ◽  
Defect Model ◽  
Critical Size Defect

Alteration of Masquelet's induced membrane characteristics by different kinds of antibiotic enriched bone cement in a critical size defect model in the rat's femur

Injury ◽  
2016 ◽  
Vol 47 (2) ◽  
pp. 325-334 ◽  
Author(s):  
Christoph Nau ◽  
Caroline Seebach ◽  
Alexander Trumm ◽  
Alexander Schaible ◽  
Kerstin Kontradowitz ◽  
...  
Keyword(s):  
Bone Cement ◽  
Critical Size ◽  
Defect Model ◽  
Critical Size Defect ◽  
Induced Membrane

scholarly journals A Standardized Critical Size Defect Model in Normal and Osteoporotic Rats to Evaluate Bone Tissue Engineered Constructs

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Livia Poser ◽  
Romano Matthys ◽  
Peter Schawalder ◽  
Simon Pearce ◽  
Mauro Alini ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Animal Model ◽  
Bone Healing ◽  
Wistar Rats ◽  
Critical Size ◽  
Osteoporotic Bone ◽  
Defect Model ◽  
Critical Size Defect ◽  
Titanium Screws ◽  
Fixation System

Tissue engineered constructs should be tested for their efficacy not only in normal but also in osteoporotic bone. The rat is an established animal model for osteoporosis and is used often for bone healing studies. In this study a defined and standardized critical size defect model in the rat suitable for screening new tissue engineered constructs in normal and osteoporotic bone is described and validated. Normal and ovariectomised Wistar rats received a unilateral middiaphyseal 5 mm defect in the femur, which was instrumented with a radiolucent PEEK plate fixed with angular stable titanium screws and left untreated. All animals were euthanized eight weeks after defect surgery and the bone healing was evaluated using radiographs, computed tomography measurements, and histology. The developed fixation system provided good stability, even in osteoporotic bone. The implants and ancillary instruments ensured consistent and facile placement of the PEEK plates. The untreated defects did not heal without intervention making the model a well-defined and standardized critical size defect model highly useful for evaluating tissue engineered solutions in normal and osteoporotic bone.

scholarly journals The masquelet induced membrane technique with BMP and a synthetic scaffold can heal a rat femoral critical size defect

2015 ◽  
Vol 33 (4) ◽  
pp. 488-495 ◽  
Author(s):  
Per Bosemark ◽  
Christina Perdikouri ◽  
Mea Pelkonen ◽  
Hanna Isaksson ◽  
Magnus Tägil
Keyword(s):  
Critical Size ◽  
Critical Size Defect ◽  
Induced Membrane ◽  
Membrane Technique ◽  
Induced Membrane Technique ◽  
Synthetic Scaffold
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