Ellagic acid protects against carrageenan-induced acute inflammation through inhibition of nuclear factor kappa B, inducible cyclooxygenase and proinflammatory cytokines and enhancement of interleukin-10 via an antioxidant mechanism

2014 ◽  
Vol 19 (2) ◽  
pp. 290-299 ◽  
Author(s):  
Nagla A. El-Shitany ◽  
Eman A. El-Bastawissy ◽  
Karema El-desoky
Keyword(s):  
Proinflammatory Cytokines ◽  
Ellagic Acid ◽  
Acute Inflammation ◽  
Nuclear Factor Kappa B ◽  
Interleukin 10 ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Antioxidant Mechanism

Lycopsamine Attenuates Diabetes Mellitus via The Nuclear Factor Kappa B-Induced 5′ Adenosine Monophosphate-Activated Protein Kinase Signal Pathway

2021 ◽  
Vol 20 (1) ◽  
pp. 169-176
Author(s):  
Jingfang Hu ◽  
Jie Jin ◽  
Yan Chen ◽  
Jinyi Wei ◽  
Hanbei Chen
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Protein Kinase ◽  
Nuclear Factor Kappa B ◽  
Adenosine Monophosphate ◽  
Interleukin 10 ◽  
Diabetic Rats ◽  
Nuclear Factor ◽  
Nonesterified Fatty Acids ◽  
Nuclear Factor Kappa

Diabetes mellitus is a metabolic disorder characterized by inflammation, abnormal glycolipid metabolism, insulin resistance, and mitochondrial dysfunction leading to hyperglycemia. The aim of the present investigation was to determine the efficacy of lycopsamine in a rat model of diabetes mellitus to understand its mechanism. Lycopsamine treatment markedly lowered the level of total cholesterol, triglyceride, nonesterified fatty acids, and low-density lipoprotein in diabetic rats. There was also a reduction in interleukin-6, interleukin-10, C-reactive protein, and tumor necrosis factor-α levels. Lycopsamine treatment normalized the metabolism of lipid and glucose, insulin resistance, and body weight of diabetic rats. Findings of immunohistochemical analyses exhibited rise in precipitation of immunocytes in renal cells. Results potentially demonstrated that lycopsamine treatment remarkably reduced the nuclear factor-kappa B level and enhanced the 5′ adenosine monophosphate-activated protein kinase expression. Altogether, administration of lycopsamine suppressed the expression of inflammatory cytokines and attenuated the metabolic symptoms in diabetes mellitus experimental rats.

scholarly journals Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation

2020 ◽  
Vol 33 (3) ◽  
pp. 145-165 ◽  
Author(s):  
Sergio Rius-Pérez ◽  
Salvador Pérez ◽  
Pablo Martí-Andrés ◽  
María Monsalve ◽  
Juan Sastre
Keyword(s):  
Acute Inflammation ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

scholarly journals Nuclear Factor Kappa B Regulation of Proinflammatory Cytokines in Human Gestational Tissues In Vitro1

2002 ◽  
Vol 67 (2) ◽  
pp. 668-673 ◽  
Author(s):  
Martha Lappas ◽  
Michael Permezel ◽  
Harry M. Georgiou ◽  
Gregory E. Rice
Keyword(s):  
Proinflammatory Cytokines ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Gestational Tissues

scholarly journals Progesterone Prevents Traumatic Brain Injury-Induced Intestinal Nuclear Factor kappa B Activation and Proinflammatory Cytokines Expression in Male Rats

2007 ◽  
Vol 2007 ◽  
pp. 1-7 ◽  
Author(s):  
Gang Chen ◽  
Jinxin Shi ◽  
Yasuo Ding ◽  
Hongxia Yin ◽  
Chunhua Hang
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Proinflammatory Cytokines ◽  
Nuclear Factor Kappa B ◽  
Mucosal Injury ◽  
Therapeutic Benefit ◽  
Binding Activity ◽  
Male Rats ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

We have previously shown that traumatic brain injury (TBI) can induce an upregulation of nuclear factor kappa B (NF-κB) and proinflammatory cytokines in the gut, which play an important role in the pathogenesis of acute gut mucosal injury mediated by inflammation. In this work, we investigated whether progesterone administration modulated intestinal NF-κB activity and proinflammatory cytokines expression after TBI in male rats. As a result, we found that administration of progesterone following TBI could decrease NF-κB binding activity, NF-κB p65 protein expression, and concentrations of interleukin-1β(IL-1β), and tumor necrosis factor-α(TNF-α) in the gut. TBI-induced damages of gut structure were ameliorated after progesterone injections. The results of the present study suggest that the therapeutic benefit of post-TBI progesterone injections might be due to its inhibitory effects on intestinal NF-κB activation and proinflammatory cytokines expression.

scholarly journals Periploca forrestii saponin ameliorates CIA via suppressing proinflammatory cytokines and nuclear factor kappa-B pathways

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0176672 ◽  
Author(s):  
Chunmei Bao ◽  
Yingqin Liu ◽  
Xin Sun ◽  
Congcong Xing ◽  
Luting Zeng ◽  
...  
Keyword(s):  
Proinflammatory Cytokines ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa
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