Oral immunization with recombinant hepatitis E virus antigen displayed on the Lactococcus lactis surface enhances ORF2-specific mucosal and systemic immune responses in mice

2015 ◽  
Vol 24 (1) ◽  
pp. 140-145 ◽  
Author(s):  
Shenyang Gao ◽  
Dandan Li ◽  
Ying Liu ◽  
Enhui Zha ◽  
Tiezhong Zhou ◽  
...  
Keyword(s):  
Immune Responses ◽  
Lactococcus Lactis ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Oral Immunization ◽  
Virus Antigen ◽  
Recombinant Hepatitis

scholarly journals Chimeric Recombinant Hepatitis E Virus-like Particles as an Oral Vaccine Vehicle Presenting Foreign Epitopes

Virology ◽  
2002 ◽  
Vol 293 (2) ◽  
pp. 273-280 ◽  
Author(s):  
Masahiro Niikura ◽  
Shiki Takamura ◽  
Gisen Kim ◽  
Satoru Kawai ◽  
Masayuki Saijo ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Oral Vaccine ◽  
Hepatitis E ◽  
Recombinant Hepatitis ◽  
Virus Like Particles

Immunogenicity and protective efficacy of orally administered recombinant Lactococcus lactis expressing surface-bound HIV Env

Blood ◽  
2003 ◽  
Vol 102 (1) ◽  
pp. 223-228 ◽  
Author(s):  
Ke-Qin Xin ◽  
Yuka Hoshino ◽  
Yoshihiko Toda ◽  
Shizunobu Igimi ◽  
Yoshitsugu Kojima ◽  
...  
Keyword(s):  
Immune Responses ◽  
Lactococcus Lactis ◽  
Potential Role ◽  
Protective Efficacy ◽  
Oral Immunization ◽  
Vaccine Strategy ◽  
Regional Lymph Nodes ◽  
Viral Loads ◽  
Recombinant Lactococcus Lactis ◽  
Further Development

Abstract This study investigates whether genetically modified orally administered Lactococcus lactis (L lactis) could be used as an HIV vaccine. L lactis is immunogenic and extremely safe when delivered orally. We created a recombinant L lactis vector expressing the envelope protein of HIV on its cell surface. Oral immunization with this vector induced high levels of HIV-specific serum IgG and fecal IgA antibodies. Cell-mediated immune responses also were generated in both the regional lymph nodes and the spleen. Dendritic cells are readily infected by L lactis and appear to play a potential role in mediating the development of these immune responses. The protective efficacy of this vaccine strategy was demonstrated by challenging mice intraperitoneally with an HIV Env–expressing vaccinia virus. Their viral loads were 350-fold lower than those of control mice. These findings support the further development of L lactis–based HIV vaccines. (Blood. 2003; 102:223-228)

Role of hepatitis E virus antigen in confirming active viral replication in patients with acute viral hepatitis E infection

2013 ◽  
Vol 58 (2) ◽  
pp. 374-377 ◽  
Author(s):  
Ekta Gupta ◽  
Priyanka Pandey ◽  
Shivani Pandey ◽  
Manoj Kumar Sharma ◽  
Shiv Kumar Sarin
Keyword(s):  
Viral Replication ◽  
Viral Hepatitis ◽  
Hepatitis E Virus ◽  
Acute Viral Hepatitis ◽  
Hepatitis E ◽  
Virus Antigen ◽  
Active Viral Replication

Augmentation of Immune Responses to Hepatitis E Virus ORF2 DNA Vaccination by Codelivery of Cytokine Genes

2000 ◽  
Vol 13 (2) ◽  
pp. 169-178 ◽  
Author(s):  
RENU TUTEJA ◽  
TIAN-CHENG LI ◽  
NAOKAZU TAKEDA ◽  
SHAHID JAMEEL
Keyword(s):  
Immune Responses ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Dna Vaccination ◽  
Cytokine Genes

scholarly journals Crystallization and preliminary X-ray diffraction analysis of recombinant hepatitis E virus-like particle

2008 ◽  
Vol 64 (4) ◽  
pp. 318-322 ◽  
Author(s):  
Che-Yen Wang ◽  
Naoyuki Miyazaki ◽  
Tetsuo Yamashita ◽  
Akifumi Higashiura ◽  
Atsushi Nakagawa ◽  
...  
Keyword(s):  
Diffraction Analysis ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Recombinant Hepatitis ◽  
X Ray Diffraction ◽  
X Ray ◽  
Virus Like Particle

Structural Characterization of Recombinant Hepatitis E Virus ORF2 Proteins in Baculovirus-Infected Insect Cells

1998 ◽  
Vol 12 (1) ◽  
pp. 75-84 ◽  
Author(s):  
Robin A. Robinson ◽  
Wilson H. Burgess ◽  
Suzanne U. Emerson ◽  
Rande S. Leibowitz ◽  
Svetlana A. Sosnovtseva ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Hepatitis E Virus ◽  
Insect Cells ◽  
Hepatitis E ◽  
Recombinant Hepatitis ◽  
Infected Insect
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