16622 Granulomatous reaction to microneedling

2020 ◽  
Vol 83 (6) ◽  
pp. AB67
Author(s):  
Elizabeth Demaree ◽  
David Cleaver ◽  
Lloyd Cleaver ◽  
Nathan Cleaver ◽  
Jonathan Cleaver
Keyword(s):  
Granulomatous Reaction

scholarly journals Response patterns in adventitial layer of Echinococcus granulosus sensu stricto cysts from naturally infected cattle and sheep

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Christian Hidalgo ◽  
Caroll Stoore ◽  
María Soledad Baquedano ◽  
Ismael Pereira ◽  
Carmen Franco ◽  
...  
Keyword(s):  
Immune Response ◽  
Echinococcus Granulosus ◽  
Cystic Echinococcosis ◽  
Direct Contact ◽  
Sensu Stricto ◽  
Response Patterns ◽  
Granulomatous Reaction ◽  
Adventitial Layer ◽  
Laminated Layer ◽  
Cattle And Sheep

AbstractCystic echinococcosis is a zoonotic disease caused by the metacestode of Echinococcus granulosus sensu lato. The disease is characterized by the development of cystic structures inside viscera of the intermediate host, mainly liver and lungs. These cysts are formed by three layers: germinal, laminated, and adventitial layer, the latter being the local host immune response. Metacestodes that develop protoscoleces, the infective stage to the definitive host, are termed fertile, whereas cysts that do not produce protoscoleces are termed non-fertile. Sheep usually harbor fertile cysts while cattle usually harbor non-fertile cysts. Adventitial layers with fibrotic resolution are associated to fertile cysts, whereas a granulomatous reaction is associated with non-fertile cysts. The aim of this study was to analyze cellular distribution in the adventitial layer of fertile and non-fertile E. granulosus sensu stricto cysts found in liver and lungs of cattle and sheep. A total of 418 cysts were analyzed, 203 from cattle (8 fertile and 195 non-fertile) and 215 from sheep (64 fertile and 151 non-fertile). Fertile cysts from cattle showed mixed patterns of response, with fibrotic resolution and presence of granulomatous response in direct contact with the laminated layer, while sheep fertile cysts always displayed fibrotic resolution next to the laminated layer. Cattle non-fertile cysts display a granulomatous reaction in direct contact with the laminated layer, whereas sheep non-fertile cysts display a granulomatous reaction, but in direct contact with the fibrotic resolution. This shows that cattle and sheep cystic echinococcosis cysts have distinct local immune response patterns, which are associated to metacestode fertility.

scholarly journals Regulation by Chemokines of Circulating Dendritic Cell Precursors, and the Formation of Portal Tract–Associated Lymphoid Tissue, in a Granulomatous Liver Disease

2000 ◽  
Vol 193 (1) ◽  
pp. 35-50 ◽  
Author(s):  
Hiroyuki Yoneyama ◽  
Kenjiro Matsuno ◽  
Yanyun Zhang ◽  
Masako Murai ◽  
Meiji Itakura ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Lymphoid Tissue ◽  
Propionibacterium Acnes ◽  
Portal Tract ◽  
Lymphoid Organ ◽  
Solid Organ ◽  
Granulomatous Reaction ◽  
Portal Area ◽  
Inflammatory Protein ◽  
Macrophage Inflammatory Protein

We have studied the recruitment and roles of distinct dendritic cell (DC) precursors from the circulation into Propionibacterium acnes–induced granulomas in mouse liver. During infection, F4/80−B220−CD11c+ DC precursors appeared in the circulation, migrated into the perisinusoidal space, and matured within newly formed granulomas. Recruited DCs later migrated to the portal area to interact with T cells in what we term “portal tract–associated lymphoid tissue” (PALT). Macrophage inflammatory protein 1α attracted blood DC precursors to the sinusoidal granuloma, whereas secondary lymphoid organ chemokine (SLC) attracted mature DCs to the newly identified PALT. Anti-SLC antibody diminished PALT expansion while exacerbating granuloma formation. Therefore, circulating DC precursors can migrate into a solid organ like liver, and participate in the granulomatous reaction in response to specific chemokines.

scholarly journals Nivolumab-Induced Sarcoid-Like Granulomatous Reaction in a Patient With Advanced Melanoma

CHEST Journal ◽  
2016 ◽  
Vol 149 (5) ◽  
pp. e133-e136 ◽  
Author(s):  
François-Xavier Danlos ◽  
Cécile Pagès ◽  
Barouyr Baroudjian ◽  
Laetitia Vercellino ◽  
Maxime Battistella ◽  
...  
Keyword(s):  
Advanced Melanoma ◽  
Granulomatous Reaction

scholarly journals Substance P Signaling Contributes to Granuloma Formation inTaenia crassicepsInfection, a Murine Model of Cysticercosis

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Armandina Garza ◽  
David J. Tweardy ◽  
Joel Weinstock ◽  
Balaji Viswanathan ◽  
Prema Robinson
Keyword(s):  
Substance P ◽  
Potential Role ◽  
Cytokine Production ◽  
Taenia Solium ◽  
Granuloma Formation ◽  
Wild Type ◽  
Granulomatous Reaction ◽  
Pain Transmission ◽  
Neurokinin 1 ◽  
The Brain

Cysticercosis is an infection with larval cysts of the cestodeTaenia solium. Through pathways that are incompletely understood, dying parasites initiate a granulomatous reaction that, in the brain, causes seizures. Substance P (SP), a neuropeptide involved in pain-transmission, contributes to inflammation and previously was detected in granulomas associated with deadT. crassicepscysts. To determine if SP contributes to granuloma formation, we measured granuloma-size and levels of IL-1β, TNF-α, and IL-6 within granulomas inT. crassiceps-infected wild type (WT) mice and mice deficient in SP-precursor (SPP) or the SP-receptor (neurokinin 1, NK1). Granuloma volumes of infected SPP- and NK1-knockout mice were reduced by 31 and 36%, respectively, compared to WT mice (P<.05for both) and produced up to 5-fold less IL-1β, TNF-α, and IL-6 protein. Thus, SP signaling contributes to granuloma development and proinflammatory cytokine production inT. crassicepsinfection and suggests a potential role for this mediator in human cystercercosis.

scholarly journals Fistula With Foreign Body Granulomatous Reaction Secondary to Retained Electrodes After Pacemaker Removal

2009 ◽  
Vol 100 (8) ◽  
pp. 723-725
Author(s):  
J. Sola-Ortigosa ◽  
M. Iglesias-Sancho ◽  
E. Dilmé-Carreras ◽  
P. Umbert-Millet
Keyword(s):  
Foreign Body ◽  
Granulomatous Reaction

scholarly journals Atypical disseminated cutaneous histoplasmosis in an immunocompetent child, caused by an "aberrant" variant of Histoplasma capsulatum var. capsulatum

1999 ◽  
Vol 41 (3) ◽  
pp. 195-202 ◽  
Author(s):  
Carlos da Silva LACAZ ◽  
Gilda Maria Barbaro DEL NEGRO ◽  
Mônica Scarpelli Martinelli VIDAL ◽  
Elisabeth Maria HEINS-VACCARI ◽  
Roseli Freitas dos SANTOS ◽  
...  
Keyword(s):  
Histoplasma Capsulatum ◽  
Complement Fixation ◽  
Double Immunodiffusion ◽  
Granulomatous Reaction ◽  
Cutaneous Lesions ◽  
Biopsy Material ◽  
Specific Staining ◽  
Hyperimmune Serum ◽  
Circulating Antigen ◽  
Immunoenzymatic Assay

A case of atypical disseminated cutaneous histoplasmosis in a five-year old, otherwise healthy child, native and resident in São Paulo metropolitan area is reported. Cutaneous lesions were clinically atypical. Histologic examination disclosed a granulomatous reaction but no fungal structures could be demonstrated by specific staining nor by immunohistochemical reaction. The fungus was isolated from biopsy material on two different occasions, confirming diagnosis of an unusual fungal infection. The fungus, originally thought to be a Sepedonium sp. due to the large sized, hyaline or brownish colored tuberculated macroconidia and to lack of dimorphism (yeast form at 37 °C) produce H and M antigens, visualized by the immunodiffusion with rabbit anti-Histoplasma capsulatum hyperimmune serum. Patient’s serum sample was non reactive with H. capsulatum antigen by immunodiffusion, counterimmunoelectrophoresis and complement fixation tests, and immunoenzymatic assay failed to detect the specific circulating antigen. This serum was tested negative by double immunodiffusion when antigen obtained from one of the isolated samples was used. Both cultures were sent to Dr. Leo Kaufman, Ph.D. (Mycoses Immunodiagnostic Laboratory, CDC-Atlanta/USA), who identified them as H. capsulatum by the exoantigen and gen-probe tests. Both clinic and mycologic characteristics of the present case were atypical, suggesting the fungus isolated is an “aberrant variant” of H. capsulatum var. capsulatum, as described by SUTTON et al. in 199719. Treatment with itraconazole 100 mg/day led to cure within 90 days

Delayed granulomatous reaction and cutaneous fistula induced by retained electrodes from a cardiac pacemaker in a child

2018 ◽  
Vol 36 (1) ◽  
Author(s):  
Leire Sánchez‐Los Arcos ◽  
Marta Feito‐Rodríguez ◽  
Ana Isabel Rodríguez Bandera ◽  
Guillermo González‐López ◽  
Raúl Lucas‐Laguna
Keyword(s):  
Cardiac Pacemaker ◽  
Granulomatous Reaction ◽  
Cutaneous Fistula

An unusual green macular lesion of the gingiva: a foreign-body granulomatous reaction

2014 ◽  
Vol 117 (1) ◽  
pp. e65-e69
Author(s):  
Lucia Tettamanti ◽  
Lorenzo Azzi ◽  
Annalisa Grimaldi ◽  
David Karang ◽  
Davide Farronato ◽  
...  
Keyword(s):  
Foreign Body ◽  
Granulomatous Reaction ◽  
Macular Lesion
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