Utilizing optical coherence tomography for objective assessment of ocular torsion

2019 ◽  
Vol 23 (4) ◽  
pp. e21
Author(s):  
Haci Ugur Celik ◽  
Kara M. Cavuoto ◽  
Maja Kostic ◽  
Worawalun Honglertnapakul ◽  
Craig A. McKeown ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Objective Assessment ◽  
Optical Coherence ◽  
Ocular Torsion

scholarly journals Deep learning algorithms to isolate and quantify the structures of the anterior segment in optical coherence tomography images

2020 ◽  
pp. bjophthalmol-2019-315723
Author(s):  
Tan Hung Pham ◽  
Sripad Krishna Devalla ◽  
Aloysius Ang ◽  
Zhi-Da Soh ◽  
Alexandre H Thiery ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Objective Assessment ◽  
Anterior Segment ◽  
Angle Closure Glaucoma ◽  
Training Data ◽  
Angle Closure ◽  
Optical Coherence ◽  
Segmentation Approach ◽  
Reliable Quantification ◽  
The Given

Background/AimsAccurate isolation and quantification of intraocular dimensions in the anterior segment (AS) of the eye using optical coherence tomography (OCT) images is important in the diagnosis and treatment of many eye diseases, especially angle-closure glaucoma.MethodIn this study, we developed a deep convolutional neural network (DCNN) for the localisation of the scleral spur; moreover, we introduced an information-rich segmentation approach for this localisation problem. An ensemble of DCNNs for the segmentation of AS structures (iris, corneosclera shell adn anterior chamber) was developed. Based on the results of two previous processes, an algorithm to automatically quantify clinically important measurements were created. 200 images from 58 patients (100 eyes) were used for testing.ResultsWith limited training data, the DCNN was able to detect the scleral spur on unseen anterior segment optical coherence tomography (ASOCT) images as accurately as an experienced ophthalmologist on the given test dataset and simultaneously isolated the AS structures with a Dice coefficient of 95.7%. We then automatically extracted eight clinically relevant ASOCT measurements and proposed an automated quality check process that asserts the reliability of these measurements. When combined with an OCT machine capable of imaging multiple radial sections, the algorithms can provide a more complete objective assessment. The total segmentation and measurement time for a single scan is less than 2 s.ConclusionThis is an essential step towards providing a robust automated framework for reliable quantification of ASOCT scans, for applications in the diagnosis and management of angle-closure glaucoma.

scholarly journals Objective assessment of symptomatic vitreous floaters using optical coherence tomography: a case report

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Kevin Patrick Kennelly ◽  
James Plunkett Morgan ◽  
David Jude Keegan ◽  
Paul Patrick Connell
Keyword(s):  
Optical Coherence Tomography ◽  
Case Report ◽  
Objective Assessment ◽  
Optical Coherence ◽  
Vitreous Floaters

scholarly journals A pilot study investigating anterior segment optical coherence tomography angiography as a non-invasive tool in evaluating corneal vascularisation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hon Shing Ong ◽  
Kai Yuan Tey ◽  
Mengyuan Ke ◽  
Bingyao Tan ◽  
Jacqueline Chua ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Objective Assessment ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Non Invasive ◽  
Imaging Tool ◽  
Model Study ◽  
Animal Model Study ◽  
Endothelial Growth Factor

AbstractThe current assessment of corneal vascularisation (CV) relies on slit-lamp examination, which may be subjective. Dye-based angiographies, like indocyanine green angiography (ICGA), allows for good visualisation of anterior segment blood vessels. However, ICGA is invasive and can be associated with systemic adverse effects. Anterior segment optical coherence tomography angiography (AS-OCTA) is a non-invasive tool that has been shown to successfully delineate CV. However, there are no previous studies that have reported if AS-OCTA can determine CV stage and activity. We used an established CV model in rabbits to examine serial AS-OCTA scans of CV development and regression following treatment with anti-vascular endothelial growth factor. We compared AS-OCTA derived vascular measurements to that of ICGA determined vessel leakage and CV staging. Our results showed that AS-OCTA vessel densities and vessel branch area significantly correlated with the severity of CV based on ICGA (all p ≤ 0.05). We also found that AS-OCTA vessel densities correlated with ICGA vessel leakage time, following an inverse linear relationship (r2 = − 0.726, p < 0.01). Changes in aqueous levels of CXCL-12 and PIGF cytokines significantly correlated with AS-OCTA vessel densities (r2 = 0.736 and r2 = 0.731 respectively, all p < 0.05). In summary, we found that AS-OCTA derived vessel parameters may be useful for assessing CV severity, while vessel density correlates with CV activity and leakage. Thus, our pilot animal model study suggests that AS-OCTA may be a useful non-invasive imaging tool to provide objective assessment of CV to examine progression or response in treatment, which requires confirmation in clinical studies.

scholarly journals A Novel Method for Evaluation of Ocular Torsion Angle by Optical Coherence Tomography

2020 ◽  
Vol 9 (3) ◽  
pp. 27
Author(s):  
Katsuhide Yamadera ◽  
Hiroto Ishikawa ◽  
Ayame Imai ◽  
Mana Okamoto ◽  
Akiko Kimura ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Torsion Angle ◽  
Optical Coherence ◽  
Ocular Torsion ◽  
Novel Method

scholarly journals Optical coherence tomography angiography for the measurement of optic disc: Macular relationship

2020 ◽  
pp. 112067212090463
Author(s):  
Massimiliano Serafino ◽  
Matteo Scaramuzzi ◽  
Francesco Bonsignore ◽  
Lucia Vitale ◽  
Adriano Magli ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Disc ◽  
Human Error ◽  
Optical Coherence Tomography Angiography ◽  
Fundus Photography ◽  
Optical Coherence ◽  
Ocular Torsion ◽  
Reliable Technique ◽  
Fundus Camera ◽  
Ocular Movement

Introduction: Fundus photography is the gold standard for assessing ocular torsion over the last 30 years. However, it is not a precise and reproducible tool during clinical practice. Optical coherence tomography angiography is characterized by precise identification of the macula and the optic disc, and it could be an effective method to easily calculate the angle of ocular torsion, compared to fundus photography. The aim of this study was to show whether any difference in the measurement and the accuracy of the angle of torsion between the head of the optic nerve and the fovea was present. Methods: This is a prospective single-, referral-center study conducted at the San Giuseppe Hospital in Milan on 80 eyes of 40 adult patients, included in a random-sample way. Exclusion criteria were non-cooperation, higher refractive errors of ±3 diopters, retinal and optic disc pathologies, and ocular movement disorders. Results: Patients’ mean age was 54.3 ± 16.3 (range: 22–83) years. The angle measured by the fundus camera was 7.78° ± 3.04°, while the angle measured by the angiography was 7.09° ± 3.08° (p = .035). The mean interocular difference was 1.54° ± 3.42° for fundus photography and 0.5° ± 4.71° for angiography (p = .013). Conclusion: Optical coherence tomography angiography is a very useful, fast, precise, reproducible, and reliable technique in cooperative subjects, not inferior to the fundus camera and less prone to human error.

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