scholarly journals GW25-e5185 A New Insight into Sudden Cardiac Death in Young People - Systematic Analysis of Takotsubo Cardiomyopathy

2014 ◽  
Vol 64 (16) ◽  
pp. C198
Author(s):  
Wang Yueyue ◽  
Hai-Yan Zhu
Keyword(s):  
Sudden Cardiac Death ◽  
Young People ◽  
Takotsubo Cardiomyopathy ◽  
Cardiac Death ◽  
Systematic Analysis ◽  
Insight Into

scholarly journals A New Insight Into Sudden Cardiac Death in Young People

Medicine ◽  
2015 ◽  
Vol 94 (32) ◽  
pp. e1174 ◽  
Author(s):  
Yueyue Wang ◽  
Lei Xia ◽  
Xiaodong Shen ◽  
Guoxin Han ◽  
Dan Feng ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Young People ◽  
Cardiac Death ◽  
Insight Into

Sudden cardiac death secondary to demonstrated reperfusion ventricular fibrillation in a woman with Takotsubo cardiomyopathy

2011 ◽  
Vol 20 (4) ◽  
pp. 254-257 ◽  
Author(s):  
Martino Pepe ◽  
Domenico Zanna ◽  
Donato Quagliara ◽  
Carlo Caiati ◽  
Andrea Marzullo ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Ventricular Fibrillation ◽  
Takotsubo Cardiomyopathy ◽  
Cardiac Death

Sudden cardiac death associated with premature atheroma in the young: an autopsy study emphasising single-vessel lesions

2015 ◽  
Vol 26 (4) ◽  
pp. 743-748 ◽  
Author(s):  
Anna C. Green ◽  
Mary N. Sheppard
Keyword(s):  
Sudden Cardiac Death ◽  
Young People ◽  
Cardiac Death ◽  
Arrhythmogenic Right Ventricular Cardiomyopathy ◽  
Left Ventricular ◽  
Autopsy Study ◽  
Dual Pathology ◽  
Single Vessel ◽  
Acute Infarction ◽  
Ischaemic Damage

AbstractAimsThis is the first autopsy study in the United Kingdom to analyse the demographic and pathological characteristics of atheroma associated with sudden cardiac death in young people.MethodsAn observational retrospective study of referred cases of sudden cardiac death in the young (⩽35 years) associated with premature atheroma was carried out.ResultsIn total, 46 cases were referred, with a median age of 30 years (27, 32); 72% of the referred cases were male, with a mean body mass index of 30 kg/m2. Circumstances of death were as follows: at rest (n=21), exertion (n=7), in bed (n=7), related to drugs/alcohol (n=4), and unknown (n=7). A previous cardiac history was provided in 10 cases. A history of class A/B drug use was found in eight cases. There was macroscopic evidence of infarction in 10 cases (acute, n=3 and chronic, n=7). Microscopically, 10 cases demonstrated contraction band necrosis, 11 acute infarction, and 11 chronic infarction. Single-vessel disease predominated (n=28). The left anterior descending coronary artery was involved in 39/46 cases. Thrombosis was seen in 16 cases, mainly due to erosion; one case showed dual pathology with arrhythmogenic right ventricular cardiomyopathy and another showed left ventricular hypertrophy.ConclusionsThis study highlights premature atheroma mainly in a single vessel in young people with or without evidence of ischaemic damage in the ventricle. Dual pathology may occur. The role of arrhythmias and channelopathies are important considerations. Premature atheroma should prompt investigation for dyslipidaemias in family members.

scholarly journals Aborted Sudden Cardiac Death in a Female Patient Presenting with Takotsubo-Like Cardiomyopathy due to Epicardial Coronary Vasospasm

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Sorin Giusca ◽  
Tom Eisele ◽  
Peter Nunninger ◽  
Benedikt Münz ◽  
Grigorios Korosoglou
Keyword(s):  
Coronary Artery ◽  
Sudden Cardiac Death ◽  
Takotsubo Cardiomyopathy ◽  
Cardiac Death ◽  
Elderly Women ◽  
Apical Ballooning ◽  
Late Enhancement ◽  
Lv Function ◽  
Icd Implantation ◽  
Lv Dysfunction

Takotsubo cardiomyopathy is characterized by apical ballooning of the left ventricle (LV) in the absence of relevant coronary artery stenosis, which typically occurs in elderly women after emotional stress. Catecholamine cardiotoxicity, metabolic disturbance, and coronary microvascular impairment have previously been proposed as underlying pathophysiologic mechanisms of takotsubo cardiomyopathy, whereas myocardial stunning resulting from epicardial coronary artery vasospasm is not generally accepted as a cause of takotsubo cardiomyopathy. The prognosis of takotsubo cardiomyopathy is generally more favourable compared to myocardial infarction; however, severe complications such as rupture of the LV and life-threatening arrhythmias may occur. Herein, we describe a case of an 84-year-old female, who presented with aborted sudden cardiac death due to ventricular fibrillation. Echocardiography suggested LV apical ballooning with severely impaired LV-function, so that takotsubo cardiomyopathy was suspected. However, coronary angiography revealed epicardial spasm of the left anterior ascending, which resolved after intracoronary injection of 0.2 mg nitroglycerine. Cardiac magnetic resonance exhibited subendocardial late enhancement and echocardiography showed normalization of LV dysfunction during follow-up. The patient was put on conservative treatment with nitrates and calcium inhibitors and ICD implantation were deferred.

scholarly journals Gene polymorphisms associated with lipid metabolism disorders in young adults with risk of ­sudden cardiac death

2021 ◽  
Vol 102 (6) ◽  
pp. 805-814
Author(s):  
V A Kachnov ◽  
E V Kryukov ◽  
S N Kolyubaeva ◽  
G G Kutelev ◽  
V V Tyrenko
Keyword(s):  
At Risk ◽  
Lipid Metabolism ◽  
Sudden Cardiac Death ◽  
Young People ◽  
Mathematical Models ◽  
Cardiac Death ◽  
Gene Polymorphisms ◽  
Pon1 Gene ◽  
Lipid Metabolism Disorders ◽  
Increased Risk

Aim. To study the frequency of polymorphisms in genes associated with lipid metabolism disorders in young people with risk of sudden cardiac death, to identify the relationships between gene polymorphisms and risk factors of sudden cardiac death, and to develop mathematical models to identify the probability of carrying mutations in these genes. Methods. The study included 436 young people (mean age 19.81.6 years). A standard examination and survey by questionnaire specially developed by us were conducted to identify an increased risk of sudden cardiac death. 59 individuals with a risk of sudden cardiac death were selected. The control group was 65 people, which was comparable to the study group. A blood test was performed to determine lipid profile and polymorphisms: Leu28Pro (rs 429358) in gene APOE, C3238G (rs 5128) in gene APOC3, Gln192Arg (rs 662) in gene PON1, Ser447Ter (rs 328) in gene LPL, G250A (rs 1800588) in gene LIPC. Statistical analysis was performed using the statistical package SPSS 17.0 and Statistica 6.0. The parametric KruskalWallis test, the MannWhitney U-test, the Pearsons chi-squared test, the Spearman rank correlation coefficient, and logistic regression analysis were used. Results. We revealed a high frequency of Gln192Arg (rs 662) polymorphism in the PON1 gene in the group of individuals at risk of sudden cardiac death and its correlation with the deaths in relatives under age 50 years. Mathematical models for predicting the presence of polymorphisms in genes associated with lipid metabolism disorders have been developed. Among the developed mathematical models, the models for identifying carriers of the minor allele of Gln192Arg polymorphism in the PON1 gene, Ser447Ter in the LPL gene, and 250 GA in the LIPC gene had the highest sensitivity, specificity, and accuracy. Conclusion. In persons at risk for sudden cardiac death, it is advisable to conduct a screening for mutations in genes associated with lipid metabolism disorders, especially in Gln192Arg polymorphism in gene PON1.

scholarly journals Prevalence of Abnormal Heart Weight After Sudden Death in People Younger than 40 Years of Age

2020 ◽  
Vol 9 (18) ◽  
Author(s):  
Zachary J. Schoppen ◽  
Lauren C. Balmert ◽  
Steven White ◽  
Rachael Olson ◽  
Ponni Arunkumar ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Young People ◽  
Sudden Death ◽  
Cardiac Death ◽  
Ethnically Diverse ◽  
Reference Population ◽  
Heart Weight ◽  
Medical Examiner ◽  
Multivariable Regression ◽  
No Gold Standard

Background After sudden cardiac death in people aged <40 years, heart weight is a surrogate for cardiomegaly and a marker for cardiomyopathy. However, thresholds for cardiomegaly based on heart weight have not been validated in a cohort of cases of sudden cardiac death in young people. Methods and Results We surveyed medical examiner offices to determine which tools were used to assess heart weight norms. The survey determined that there was no gold standard for cardiomegaly (52 centers reported 22 different methods). We used a collection of heart weight data from sudden deaths in the Northwestern Sudden Death Collaboration (NSDC) to test the 22 methods. We found that the methods reported in our survey had little consistency: they classified between 18% and 81% of NSDC hearts with cardiomegaly. Therefore, we obtained biometric and postmortem data from a reference population of 3398 decedents aged <40 years. The reference population was ethnically diverse and had no known cardiac pathology on autopsy or histology. We derived and validated a multivariable regression model to predict normal heart weights and a threshold for cardiomegaly (upper 95% CI limit) in the young reference population (the Chicago model). Using the new model, the prevalence of cardiomegaly in hearts from the NSDC was 19%. Conclusions Medical examiner offices use a variety of tools to classify cardiomegaly. These approaches produce inconsistent results, and many overinterpret cardiomegaly. We recommend the model proposed to classify postmortem cardiomegaly in cases of sudden cardiac death in young people.

scholarly journals Hypertrophic Cardiomyopathy–Related Sudden Cardiac Death in Young People in Ontario

Circulation ◽  
2019 ◽  
Vol 140 (21) ◽  
pp. 1706-1716 ◽  
Author(s):  
Adaya Weissler-Snir ◽  
Katherine Allan ◽  
Kristopher Cunningham ◽  
Kim A. Connelly ◽  
Douglas S. Lee ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Sudden Cardiac Death ◽  
Young People ◽  
Cardiac Death

Association of arterial hypertension gene polymorphisms with the risk of sudden cardiac death in young people

2020 ◽  
Vol 22 (3) ◽  
pp. 18-22
Author(s):  
V. A. Kachnov ◽  
V. V. Tyrenko ◽  
S. N. Kolubaeva ◽  
D. V. Cherkashin ◽  
G. G. Kutelev ◽  
...  
Keyword(s):  
At Risk ◽  
Sudden Cardiac Death ◽  
Young People ◽  
Arterial Hypertension ◽  
Mathematical Models ◽  
Cardiac Death ◽  
Left Ventricular ◽  
Risk Variants ◽  
Close Relatives ◽  
The Relationship

Abstract. The frequency of occurrence of arterial hypertension genes in individuals at risk of sudden cardiac death was studied. The relationship between risk factors for sudden cardiac death and the presence of polymorphisms of arterial hypertension genes was revealed. There was a high incidence of homozygous risk variants AGTR2 AA and CYP11B2 TT-polymorphisms responsible for the development of left ventricular hypertrophy, including in young individuals. A correlation was found between deaths in close relatives under 50 years of age and the presence of polymorphisms in the CYP11B2 344 CT gene in young people at risk of sudden cardiac death. We have obtained data indicating the feasibility of conducting a study of the polymorphism of the CYP11B2 gene in the presence of a risk of sudden cardiac death. A direct correlation was found between the presence of fatal outcomes in relatives under 50 years of age by the mechanism of sudden cardiac death and the number of homozygous variants of arterial hypertension genes. Mathematical models for predicting the presence of polymorphisms in genes responsible for the possibility of arterial hypertension are constructed. Among the constructed mathematical models, the most informative were models for detecting carriers of mutations in the genes ADD1 1378 GT, CYP11B2 344 CT and NOS3 894 GT. The expediency of the analysis to search for mutations of arterial hypertension genes, especially in the CYP11B2 344 CT gene, for the possibility of earlier and more intensive preventive measures in young people is shown. The data obtained indicate that there are relationships between the risk of sudden cardiac death, some known predictors of its occurrence, and the genes for arterial hypertension.

Sign in / Sign up

Export Citation Format

Share Document