scholarly journals TCTAP A-126 Mortality Rates and Mortality Predictors in Patients with Symptomatic Peripheral Artery Disease Treated Endovascular Treatment

2017 ◽  
Vol 69 (16) ◽  
pp. S70-S71
Author(s):  
Atsusuke Yatomi ◽  
Hiroaki Nakamura ◽  
Makoto Kadotani
Keyword(s):  
Endovascular Treatment ◽  
Peripheral Artery Disease ◽  
Mortality Rates ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Mortality Predictors

scholarly journals Mortality rates and mortality predictors in patients with symptomatic peripheral artery disease stratified according to age and diabetes

2014 ◽  
Vol 59 (5) ◽  
pp. 1291-1299 ◽  
Author(s):  
Thomas Mueller ◽  
Franz Hinterreiter ◽  
Christian Luft ◽  
Werner Poelz ◽  
Meinhard Haltmayer ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Mortality Rates ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Mortality Predictors

scholarly journals Cholesterol Efflux Capacity Associates with the Ankle-Brachial Index but Not All-Cause Mortality in Patients with Peripheral Artery Disease

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1407
Author(s):  
Robert K. Clemens ◽  
Monika Hunjadi ◽  
Andreas Ritsch ◽  
Lucia Rohrer ◽  
Thomas O. Meier ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Cholesterol Efflux ◽  
Ankle Brachial Index ◽  
Mortality Rates ◽  
High Density Lipoproteins ◽  
Peripheral Artery ◽  
Cholesterol Efflux Capacity ◽  
Hdl Function ◽  
All Cause Mortality ◽  
Artery Disease

Background: Cholesterol efflux is an important mechanism by which high-density lipoproteins (HDLs) protect against cardiovascular disease. As peripheral artery disease (PAD) is associated with high mortality rates, mainly due to cardiovascular causes, we investigated whether cholesterol efflux capacity (CEC) of apolipoprotein B (apoB)-depleted plasma, a widely used surrogate of HDL function, may serve as a predictive marker for mortality in this patient population. Methods: In this prospective single-center study (median follow-up time: 9.3 years), apoB-containing lipoproteins were precipitated from plasma of 95 patients with PAD and incubated with J744-macrophages, which were loaded with radiolabeled cholesterol. CEC was defined as the fractional radiolabel released during 4 h of incubation. Results: Baseline CEC was lower in PAD patients that currently smoked (p = 0.015) and had a history of myocardial infarction (p = 0.011). Moreover, CEC showed a significant correlation with HDL-cholesterol (p = 0.003) and apolipoprotein A-I levels (p = 0.001) as well as the ankle-brachial index (ABI, p = 0.018). However, CEC did not differ between survivors and non-survivors. Neither revealed Kaplan–Meier and Cox regression analyses any significant association of CEC with all-cause mortality rates. Conclusion: Taken together, CEC is associated with ABI but does not predict all-cause mortality in patients with PAD.

Endovascular treatment of peripheral artery disease is associated with improved central hemodynamics and ventricular function

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
D Messiha ◽  
L Halfmann ◽  
O Azizy ◽  
M Steinmetz ◽  
T Rassaf ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Left Ventricular Function ◽  
Endovascular Treatment ◽  
Ventricular Function ◽  
Peripheral Artery Disease ◽  
Cardiovascular Mortality ◽  
Left Ventricular ◽  
Central Hemodynamics ◽  
Peripheral Artery ◽  
Artery Disease

Abstract Background Peripheral artery disease (PAD) is a major manifestation of atherosclerosis and a risk factor for morbidity and mortality. PAD itself is associated with increased arterial stiffness with impact on cardiac functions. Previous studies have demonstrated that augmentation index (AIx) and central blood pressure (CBP) correlate with increased cardiovascular mortality. This mechanism has been described as arterio-ventricular (AV) coupling with altered ventricular afterload and a depressed ventricular function, measured by global longitudinal strain (GLS). The impact of PAD-related endovascular treatment on arterial stiffness, central hemodynamics and potential impact on AV coupling has not been elucidated until now. Purpose Aim of the study was to investigate, if endovascular treatment of PAD improves cardiac function via enhanced central hemodynamics and AV coupling. Methods To this aim 77 patients with known symptomatic PAD who underwent interventions in the iliac and femoropopliteal arteries were included in a cross-sectional study. AIx, CBP and GLS were determined using dedicated waveform analysis and echocardiography before and after endovascular treatment. Results Mean age was 65.1±10.4 years with 66.2% male patients. Symptoms were classified by Fontaine classification (stage IIb 80.7%, stage III 5.8% and stage IV 13.5%). Iliac vessel intervention was performed in 16 and femoropopliteal intervention in 61 cases. A stentless approach was feasible in 55 patients with DCB treatment and atherectomy. After endovascular treatment, peripheral perfusion was enhanced (ABI 0.45±0.6 vs 0.81±0.5, p<0.0001). Moreover, central hemodynamics were improved (AIX 33.7±3% vs 27.9±2%, p=0.0008; AP 17.8±2 mmHg vs 14.0±2 mmHg, p=0.0004; central PP 52.4±6 mmHg vs 46.4±6 mmHg, p=0.0001). Impressively, left ventricular function was also significantly improved (GLS −15.7±2.3% vs −17.1±2.8%, p=0.005) with an improvement in AV coupling (PWV/GLS ratio −0.58m/sec% vs −0.56m/sec%, p<0.01). Conclusion Our results demonstrate that endovascular treatment of the peripheral vessels is associated with an improvement of central hemodynamics and left ventricular function via enhanced AV coupling. These prognostic relevant markers of cardiovascular disease could point to an overall potential mortality benefit through PAD treatment. Further investigation of the underlying mechanisms of AV coupling in the setting of endovascular treatment of PAD with impact on cardiovascular mortality is needed in this high-risk population. Funding Acknowledgement Type of funding source: None

Peripheral artery disease. Part 2: medical and endovascular treatment

2011 ◽  
Vol 8 (8) ◽  
pp. 429-441 ◽  
Author(s):  
Mitchell D. Weinberg ◽  
Joe F. Lau ◽  
Kenneth Rosenfield ◽  
Jeffrey W. Olin
Keyword(s):  
Endovascular Treatment ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Artery Disease
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