Galactose-alpha-1,3-galactose sensitization is a prerequisite for pork-kidney allergy and cofactor-related mammalian meat anaphylaxis

2014 ◽  
Vol 134 (3) ◽  
pp. 755-759.e1 ◽  
Author(s):  
Jörg Fischer ◽  
Johanna Hebsaker ◽  
Patricia Caponetto ◽  
Thomas A.E. Platts-Mills ◽  
Tilo Biedermann
Keyword(s):  
Author(s):  
A.N. Pampura ◽  
E.E. Varlamov

Продукты животного происхождения обладают наиболее сбалансированным комплексом необходимых нутриентов, поэтому их включение в пищевой рацион оправданно в различные возрастные периоды. Клинические проявления аллергии к данным продуктам крайне разнообразны. Одним из ключевых аспектов обозначенной проблемы является диагностика и оценка вероятности развития перекрестной реактивности. К пищевым продуктам животного происхождения, наиболее часто индуцирующим симптомы, относятся коровье молоко, куриное яйцо, рыба, моллюски, ракообразные, мясо млекопитающих. В представленной статье изложены данные об основных классах пищевых аллергенов животного происхождения, индуцирующих развитие перекрестных аллергических реакций. Описаны синдромы, связанные с перекрестной реактивностью: птица-яйцо , кошка-свинина , рыба-курица и -Gal-синдром/ синдром красного мяса .Animal foods products contain the most balanced complex of essential nutrients. The clinical manifestations of allergy to these products are varied. Key aspect of this problem is diagnostics and assessment of cross-reactivity. The food animal products that more often induce symptoms include cows milk, hens egg, fish, mollusks, crustaceans, mammalian meat. Data on the main classes of food animal allergens inducing the development of cross-allergic reactions as well as syndromes associated with cross-reactivity like bird-egg , cat-pork , fish-chicken and a-Gal-syndrome/ red meat syndrome are described in this article.


2019 ◽  
Vol 7 (2) ◽  
pp. 664-666 ◽  
Author(s):  
Lindsey P. Stoltz ◽  
Leslie M. Cristiano ◽  
Ashley P.G. Dowling ◽  
Jeffrey M. Wilson ◽  
Thomas A.E. Platts-Mills ◽  
...  
Keyword(s):  

2020 ◽  
Vol 3 (1) ◽  
pp. 18-21
Author(s):  
Wahid Lana ◽  
◽  
Aziz Sameh ◽  
Abraham Christina ◽  
◽  
...  

Anaphylaxis is a serious life-threatening allergic reaction that typically has an immediate onset. It can present as flushing, angioedema, shortness of breath, rash and result in death if not treated immediately. In the past ten years, an emerging cause of delayed anaphylaxis has been identified. An IgE antibody to a mammalian oligosaccharide epitope (alpha-gal, or galactose-alpha-1,3-galactose) has been linked to both immediate and delayed onset anaphylaxis. The immediate form is associated with the first exposure to cetuximab; whereas the delayed onset occurs after ingestion of mammalian meat such as beef and pork. The presentation can develop 2-6 hours after ingestion. This IgE antibody to alpha-gal is strongly suggested that Lone Star tick bites have been the culprit. It is imperative when caring for an anaphylaxis patient of unknown etiology, to consider a line of questioning to not only include recent tick bites, but also last 2-3 meals ingested to identify if mammalian meat may have been the trigger.


Author(s):  
Esben Eller ◽  
Per Stahl Skov ◽  
Katrine Baumann ◽  
Christiane Hilger ◽  
Markus Ollert ◽  
...  

2019 ◽  
Vol 143 (2) ◽  
pp. AB256
Author(s):  
Monica Gupta ◽  
Lisa Workman ◽  
Alexander J. Schuyler ◽  
Scott P. Commins ◽  
Thomas A.E. Platts-Mills ◽  
...  
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