Patients with positive skin test results to penicillin should not undergo penicillin or amoxicillin challenge

Background Few studies have examined the relationship between subject-reported allergy and results of allergy skin testing in large unselected or unbiased cohorts. The objective of this study was to compare the results of self-reported allergy via verbal questioning with the results of allergy skin testing by the puncture method in 237 healthy adult subjects enrolled in a common cold study. Methods On enrollment, all subjects were verbally asked if they had a history of allergy and then underwent puncture skin testing to 19 relevant aeroallergens, as well as appropriate positive and negative controls. A skin test was considered positive if its wheal diameter was at least 3 mm larger than that obtained with the negative control. Results Forty-eight (20%) subjects reported a history of allergy and 124 (52%) subjects had at least one positive skin test response. A history of allergy was reported in 40 (32%) of the skin test-positive subjects and 8 (7%) of the skin test-negative subjects. At least one positive skin test response was found in 40 (83%) of those subjects reporting a history of allergy and 84 (44%) of those subjects denying a history of allergy. Conclusion These data indicate that there is a relatively poor correlation between self-reported history of allergy and skin test results in subjects enrolled in a common cold study. These results have implications in both clinical practice and research settings.

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Interpretation of isolated positive skin test results for mesquite tree pollen

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2004.05.011 ◽

2004 ◽

Vol 114 (2) ◽

pp. 452-454 ◽

Cited By ~ 2

Author(s):

John M Kelso

Keyword(s):

Skin Test ◽

Positive Skin Test ◽

Test Results ◽

Tree Pollen ◽

Positive Skin

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Gadolinium-induced anaphylaxis with positive skin test results

Annals of Allergy Asthma & Immunology ◽

10.1016/j.anai.2019.03.022 ◽

2019 ◽

Vol 122 (6) ◽

pp. 654-655 ◽

Cited By ~ 1

Author(s):

Guillermo Rodriguez-Nava ◽

Alex M. Kesler ◽

Ismael Carrillo-Martin ◽

Alexei Gonzalez-Estrada

Keyword(s):

Skin Test ◽

Positive Skin Test ◽

Test Results ◽

Positive Skin

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Sequential degranulation of eosinophils induced by antigen or autocoids in allergic humans

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100143390 ◽

1986 ◽

Vol 44 ◽

pp. 354-355

Author(s):

Kate W. Sjoerdsma ◽

W. James Metzger

Keyword(s):

Allergic Rhinitis ◽

Bronchoalveolar Lavage ◽

Allergic Asthma ◽

Skin Test ◽

Positive Skin Test ◽

Positive Skin ◽

Human Eosinophil ◽

Asthmatic Patients ◽

Allergic Asthmatic ◽

History Of

Eosinophils are important to the pathogenesis of allergic asthma, and are increased in bronchoalveolar lavage within four hours after bronchoprovocation of allergic asthmatic patients, and remain significantly increased up to 24 hours later. While the components of human eosinophil granules have been recently isolated and purified, the mechanisms of degranulation have yet to be elucidated.We obtained blood from two volunteers who had a history of allergic rhinitis and asthma and a positive skin test (5x5mm wheal) to Alternaria and Ragweed. Eosinophils were obtained using a modification of the method described by Roberts and Gallin.

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Penicillin Hypersensitivity

Pediatrics in Review ◽

10.1542/pir.1.5.132 ◽

1979 ◽

Vol 1 (5) ◽

pp. 132-158

Keyword(s):

Skin Test ◽

Multicenter Study ◽

Positive Skin Test ◽

Penicillin Allergy ◽

Skin Tests ◽

Penicillin G ◽

Positive Skin ◽

Positive History ◽

History Of

A (massive) multicenter study of 3,000 patients has demonstrated that skin tests to penicillin G and penicilloyl-polylysine (PPL-now commercially available) predict and confirm penicillin allergy. Of patients with a history of penicillin reaction, 19% were positive to either, compared to 7% of controls. A history of anaphylaxis led to 46% positive. Of those with a history of urticaria 17% were positive, and those with maculopapular eruptions did not differ from controls (7% positive). Challenge with penicillin led to a reaction in 6% with a positive history (compared to 2% with a negative) and 67% with a combined positive history and positive skin test (to either).

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