Evaluation of pulmonary function by impulse oscillometry in pre-school children with asthma

Abstract Background Subjects with chronic respiratory symptoms and preserved pulmonary function (PPF) may have small airway dysfunction (SAD). As the most common means to detect SAD, spirometry needs good cooperation and its reliability is controversial. Impulse oscillometry (IOS) may complete the deficiency of spirometry and have higher sensitivity. We aimed to explore the diagnostic value of IOS to detect SAD in symptomatic subjects with PPF. Methods The evaluation of symptoms, spirometry and IOS results in 209 subjects with chronic respiratory symptoms and PPF were assessed. ROC curves of IOS to detect SAD were analyzed. Results 209 subjects with chronic respiratory symptoms and PPF were included. Subjects who reported sputum had higher R5–R20 and Fres than those who didn’t. Subjects with dyspnea had higher R5, R5–R20 and AX than those without. CAT and mMRC scores correlated better with IOS parameters than with spirometry. R5, R5–R20, AX and Fres in subjects with SAD (n = 42) significantly increased compared to those without. Cutoff values for IOS parameters to detect SAD were 0.30 kPa/L s for R5, 0.015 kPa/L s for R5–R20, 0.30 kPa/L for AX and 11.23 Hz for Fres. Fres has the largest AUC (0.665, P = 0.001) among these parameters. Compared with spirometry, prevalence of SAD was higher when measured with IOS. R5 could detect the most SAD subjects with a prevalence of 60.77% and a sensitivity of 81% (AUC = 0.659, P = 0.002). Conclusion IOS is more sensitive to detect SAD than spirometry in subjects with chronic respiratory symptoms and PPF, and it correlates better with symptoms. IOS could be an additional method for SAD detection in the early stage of diseases.

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Utility Of Impulse Oscillometry In Young Children With Asthma

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2007.12.020 ◽

2008 ◽

Vol 121 (2) ◽

pp. S4-S4 ◽

Cited By ~ 2

Author(s):

T SONG ◽

K KIM ◽

M SOHN ◽

K KIM ◽

E KIM

Keyword(s):

Young Children ◽

Impulse Oscillometry ◽

Children With Asthma

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Association between Residential Tobacco Smoking Bans, Smoke Exposure, and Pulmonary Function: A Survey of Latino Children with Asthma

Pediatric Asthma Allergy & Immunology ◽

10.1089/088318703322751354 ◽

2003 ◽

Vol 16 (4) ◽

pp. 305-317 ◽

Cited By ~ 6

Author(s):

Ana P. Martinez-Donate ◽

Melbourne F. Hovell ◽

Dennis R. Wahlgren ◽

Susan B. Meltzer ◽

Eli O. Meltzer ◽

...

Keyword(s):

Pulmonary Function ◽

Tobacco Smoking ◽

Smoke Exposure ◽

Latino Children ◽

Smoking Bans ◽

Children With Asthma

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Evaluation of daily home spirometry for school children with asthma: New insights

Pediatric Pulmonology ◽

10.1002/ppul.20449 ◽

2006 ◽

Vol 41 (9) ◽

pp. 819-828 ◽

Cited By ~ 10

Author(s):

Rohan Thompson ◽

Ralph J. Delfino ◽

Thomas Tjoa ◽

Eliezer Nussbaum ◽

Dan Cooper

Keyword(s):

School Children ◽

Children With Asthma

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Association between TBXA2R T924C polymorphism and pulmonary function in Korean children with asthma*1

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2004.01.178 ◽

2004 ◽

Vol 113 (2) ◽

pp. S204

Author(s):

S LEE

Keyword(s):

Pulmonary Function ◽

Korean Children ◽

Children With Asthma

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Characterization of baltimore city school children with asthma evaluated on the breathmobile

Journal of Allergy and Clinical Immunology ◽

10.1016/s0091-6749(03)81233-2 ◽

2003 ◽

Vol 111 (2) ◽

pp. S336-S337

Author(s):

C.D. Schwindt ◽

C. Blaisdell ◽

M. Ramagopal ◽

S. Irving ◽

M. Foster ◽

...

Keyword(s):

School Children ◽

Baltimore City ◽

City School ◽

Children With Asthma

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The Effect of Physical Training in Children With Asthma on Pulmonary Function, Aerobic Capacity and Health-Related Quality of Life: A Systematic Review of Randomized Control Trials

Pediatric Exercise Science ◽

10.1123/pes.24.3.472 ◽

2012 ◽

Vol 24 (3) ◽

pp. 472-489 ◽

Cited By ~ 19

Author(s):

Alison Crosbie

Keyword(s):

Quality Of Life ◽

Pulmonary Function ◽

Aerobic Capacity ◽

Physical Training ◽

Health Related Quality ◽

Children With Asthma ◽

Related Quality ◽

Health Related ◽

Randomized Control

ObjectiveAsthma is a leading cause of chronic illness in children, impacting heavily on their daily life and participation in physical activity. The purpose of this systematic review was to investigate the evidence for the use of physical therapy to improve pulmonary function and aerobic capacity in children with asthma. Furthermore, the review aims to update previous literature on the effect of exercise on health related quality of life.MethodsA search was conducted for randomized control trials (RCTs) using the electronic databases Medline, Embase, SPORTDiscus, AMED, CINAHL, and The Cochrane Central Register of Controlled Trials. Studies were included if the participants were asthmatic children aged 6–18 years participating in any mode of physical exercise. Studies were reviewed for study quality, participant details, exercise intervention details, and intervention outcomes.ResultsA total of 16 studies and 516 subjects met inclusion criteria for review. Severity of asthma ranged from mild to severe. No improvement in pulmonary function was observed. Physical training led to an increase in aerobic capacity as measured by VO2max (mL/kg/min).ConclusionsFindings suggest that physical training does not improve pulmonary function in children with asthma, but does increase aerobic capacity. The small number of studies investigating quality of life suggests that physical training does improve health related quality of life; however further well designed randomized control trials are needed to verify these findings.

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