Mitochondrial complex I and III mRNA levels in bipolar disorder

2015 ◽  
Vol 184 ◽  
pp. 160-163 ◽  
Author(s):  
Süleyman Akarsu ◽  
Deniz Torun ◽  
Murat Erdem ◽  
Salih Kozan ◽  
Hatice Akar ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Complex I ◽  
Mitochondrial Complex I ◽  
Mrna Levels ◽  
Mitochondrial Complex

Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees

2004 ◽  
Vol 56 (7) ◽  
pp. 483-489 ◽  
Author(s):  
Shinsuke Washizuka ◽  
Kazuya Iwamoto ◽  
An-a Kazuno ◽  
Chihiro Kakiuchi ◽  
Kanako Mori ◽  
...  
Keyword(s):  
Mental Health ◽  
Bipolar Disorder ◽  
Complex I ◽  
Mitochondrial Complex I ◽  
Subunit Gene ◽  
Mitochondrial Complex

scholarly journals Mitochondrial Complex I Deficiency in Schizophrenia and Bipolar Disorder and Medication Influence

2017 ◽  
Vol 3 (3) ◽  
pp. 157-169 ◽  
Author(s):  
Brandi L. Rollins ◽  
Ling Morgan ◽  
Brooke E. Hjelm ◽  
Adolfo Sequeira ◽  
Alan F. Schatzberg ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Complex I ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Complex I Deficiency

Increased mRNA levels of the mitochondrial complex I 75-kDa subunit

2006 ◽  
Vol 15 (8) ◽  
pp. 504-507 ◽  
Author(s):  
Claudia Mehler-Wex ◽  
J. Catharina Duvigneau ◽  
Romana T. Hartl ◽  
Dorit Ben-Shachar ◽  
Andreas Warnke ◽  
...  
Keyword(s):  
Complex I ◽  
Mitochondrial Complex I ◽  
Mrna Levels ◽  
Mitochondrial Complex

scholarly journals The Potential Role of the NLRP3 Inflammasome as a Link between Mitochondrial Complex I Dysfunction and Inflammation in Bipolar Disorder

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Helena Kyunghee Kim ◽  
Wenjun Chen ◽  
Ana Cristina Andreazza
Keyword(s):  
Bipolar Disorder ◽  
Nlrp3 Inflammasome ◽  
Complex I ◽  
Potential Role ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Therapeutic Implications ◽  
Pyrin Domain ◽  
Redox Sensor

Mitochondrial dysfunction and activation of the inflammatory system are two of the most consistently reported findings in bipolar disorder (BD). More specifically, altered levels of inflammatory cytokines and decreased levels of mitochondrial complex I subunits have been found in the brain and periphery of patients with BD, which could lead to increased production of mitochondrial reactive oxygen species (ROS). Recent studies have shown that mitochondrial production of ROS and inflammation may be closely linked through a redox sensor known as nod-like receptor pyrin domain-containing 3 (NLRP3). Upon sensing mitochondrial release of ROS, NLRP3 assembles the NLRP3 inflammasome, which releases caspase 1 to begin the inflammatory cascade. In this review, we discuss the potential role of the NLRP3 inflammasome as a link between complex I dysfunction and inflammation in BD and its therapeutic implications.

scholarly journals Mitochondrial complex I and III gene mRNA levels in schizophrenia, and their relationship with clinical features

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Süleyman Akarsu ◽  
Deniz Torun ◽  
Abdullah Bolu ◽  
Murat Erdem ◽  
Salih Kozan ◽  
...  
Keyword(s):  
Clinical Features ◽  
Complex I ◽  
Mitochondrial Complex I ◽  
Mrna Levels ◽  
Mitochondrial Complex ◽  
Gene Mrna
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