48. Eating Disorders and Sleep Disturbances in Young Adults: A Prospective Cohort Study

2020 ◽  
Vol 66 (2) ◽  
pp. S26
Author(s):  
Jason M. Nagata ◽  
Idia B. Thurston ◽  
Bryan Karazsia ◽  
Daniel Woolridge ◽  
Sara Buckelew ◽  
...  
2020 ◽  
Author(s):  
Lili Dai ◽  
Sen Wang ◽  
Ying Shao ◽  
Yali Wang ◽  
Jiangzhu Ye ◽  
...  

Abstract Background: Efavirenz (EFV) is a widely used antiretroviral therapy (ART), but side effect risks of neuropsychiatric adverse events (NPAEs) have not been investigated in Chinese populations receiving rapid ART. Methods: This prospective cohort study assessed HIV-infected patients initiating antiretroviral treatment with EFV to determine prevalence of and factors associated with NPAEs over a 12-month follow-up period using the Hospital Anxiety and Depression Scale (HADS) and the Pittsburgh Sleep Quality Index (PSQI). Results: A total of 546 patients were enrolled. Prevalence of anxiety, depression, and sleep disturbances at baseline were 30.4%, 22.7%, and 68.1%, respectively. Six patients discontinued treatment due to drug related NPAEs. Treatment was associated with improvements in HADS-A, HADS-D, and PSQI scores over the 12-month follow-up, and the frequencies of patients with anxiety, depression, and sleep disturbances significantly decreased after 12 months. Abnormal baseline HADS-A, HADS-D, and PSQI scores and other factors, including high school education or lower, unemployment, divorce, and WHO III/IV stages, were associated with severe neuropsychiatric disorders over the 12 months. Conclusions: These findings suggested EFV-based first-line antiretroviral therapy was well-tolerated and associated with improvements in HADS-A, HADS-D, and PSQI scores. Certain risk factors associated with neuropsychiatric disorders may be useful in identifying HIV-infected patients at higher NPAE risk.


2019 ◽  
Vol 52 (12) ◽  
pp. 1380-1388 ◽  
Author(s):  
Jason M. Nagata ◽  
Stuart B. Murray ◽  
Kirsten Bibbins‐Domingo ◽  
Andrea K. Garber ◽  
Deborah Mitchison ◽  
...  

SLEEP ◽  
2009 ◽  
Vol 32 (11) ◽  
pp. 1459-1466 ◽  
Author(s):  
Jussi Vahtera ◽  
Hugo Westerlund ◽  
Martica Hall ◽  
Noora Sjösten ◽  
Mika Kivimäki ◽  
...  

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