CME Exam: Skin Barrier and Immune Dysregulation in Atopic Dermatitis: An Evolving Story with Important Clinical Implications

2014 ◽  
Vol 2 (4) ◽  
pp. 380-381
Keyword(s):  
Atopic Dermatitis ◽  
Skin Barrier ◽  
Immune Dysregulation ◽  
Clinical Implications

scholarly journals Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis

2020 ◽  
Vol 21 (8) ◽  
pp. 2867 ◽  
Author(s):  
Gabsik Yang ◽  
Jin Kyung Seok ◽  
Han Chang Kang ◽  
Yong-Yeon Cho ◽  
Hye Suk Lee ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Systemic Disease ◽  
Skin Barrier ◽  
Immune Dysregulation ◽  
Food Allergies ◽  
Atopic Diseases ◽  
Barrier Dysfunction ◽  
Underlying Mechanisms ◽  
Chronic Pruritus ◽  
And Function

Atopic dermatitis (AD) is a common and relapsing skin disease that is characterized by skin barrier dysfunction, inflammation, and chronic pruritus. While AD was previously thought to occur primarily in children, increasing evidence suggests that AD is more common in adults than previously assumed. Accumulating evidence from experimental, genetic, and clinical studies indicates that AD expression is a precondition for the later development of other atopic diseases, such as asthma, food allergies, and allergic rhinitis. Although the exact mechanisms of the disease pathogenesis remain unclear, it is evident that both cutaneous barrier dysfunction and immune dysregulation are critical etiologies of AD pathology. This review explores recent findings on AD and the possible underlying mechanisms involved in its pathogenesis, which is characterized by dysregulation of immunological and skin barrier integrity and function, supporting the idea that AD is a systemic disease. These findings provide further insights for therapeutic developments aiming to repair the skin barrier and decrease inflammation.

scholarly journals Advances in understanding and managing atopic dermatitis

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 1296 ◽  
Author(s):  
Michael Barton ◽  
Robert Sidbury
Keyword(s):  
Atopic Dermatitis ◽  
Natural History ◽  
Skin Disease ◽  
Allergic Sensitization ◽  
Therapeutic Targets ◽  
Skin Barrier ◽  
Immune Dysregulation ◽  
Pruritic Skin

Atopic dermatitis is a chronic, pruritic skin disease characterized by an improperly functioning skin barrier and immune dysregulation. We review proposed atopic dermatitis pathomechanisms, emphasizing how these impact current perspectives on natural history, role of allergic sensitization, and future therapeutic targets.

Update on the Structure and Function of the Skin Barrier: Atopic Dermatitis as an Exemplar of Clinical Implications

2013 ◽  
Vol 32 (2S) ◽  
pp. S21-S24 ◽  
Author(s):  
Peter Elias ◽  
Lawrence Eichenfield ◽  
Joseph Fowler ◽  
Paul Horowitz ◽  
Renee McLeod
Keyword(s):  
Atopic Dermatitis ◽  
Skin Barrier ◽  
Structure And Function ◽  
Clinical Implications ◽  
And Function

scholarly journals Associations between atopic dermatitis and other disorders

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 303 ◽  
Author(s):  
Jonathan I. Silverberg
Keyword(s):  
Atopic Dermatitis ◽  
Sleep Disturbances ◽  
Symptom Burden ◽  
Skin Barrier ◽  
Immune Dysregulation ◽  
Comorbid Conditions ◽  
Inflammatory Skin Disease ◽  
Iatrogenic Complications ◽  
Recent Developments ◽  
Health Disorders

Atopic dermatitis is a heterogeneous, chronic, and inflammatory skin disease that is associated with a profound symptom burden. Recent studies have demonstrated associations between atopic dermatitis and a number of multi-organ and systemic disorders. The origin of these comorbid conditions is likely multifactorial, with combined effects of skin-barrier disruption, immune dysregulation, intense symptoms, and iatrogenic complications. Some of these comorbid conditions appear to be related to the underlying severity of atopic dermatitis and inadequate disease control. This review will summarize recent developments in the understanding of the comorbid health disorders associated with atopic dermatitis, particularly infections, sleep disturbances, and cardiovascular disease.

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