scholarly journals P-020: Regional gray matter reductions in Alzheimer's dementia and amnestic mild cognitive impairment: Preliminary findings from the Alzheimer's disease neuroimaging initiative using voxel-based morphometry

2007 ◽  
Vol 3 (3S_Part_1) ◽  
pp. S102-S102 ◽  
Author(s):  
Gene E. Alexander ◽  
Kewei Chen ◽  
Eric M. Reiman ◽  
Melaney Aschenbrenner ◽  
Tricia L. Merkley ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Gray Matter ◽  
Amnestic Mild Cognitive Impairment ◽  
Alzheimer’S Dementia ◽  
Voxel Based Morphometry ◽  
Alzheimer's Dementia

P3-060: Voxel-based morphometry of amnestic mild cognitive impairment and Alzheimer's disease

2009 ◽  
Vol 5 (4S_Part_12) ◽  
pp. P359-P359 ◽  
Author(s):  
Yi He ◽  
Mei-Yan Zhang ◽  
Kevin Head ◽  
Daniel Chang ◽  
Huishu Yuan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Voxel Based Morphometry

scholarly journals Divergent Connectivity Changes in Gray Matter Structural Covariance Networks in Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment, and Alzheimer’s Disease

2021 ◽  
Vol 13 ◽  
Author(s):  
Zhenrong Fu ◽  
Mingyan Zhao ◽  
Yirong He ◽  
Xuetong Wang ◽  
Jiadong Lu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Amnestic Mild Cognitive Impairment ◽  
Subjective Cognitive Decline ◽  
Structural Covariance ◽  
Cholinergic Basal Forebrain

Alzheimer’s disease (AD) has a long preclinical stage that can last for decades prior to progressing toward amnestic mild cognitive impairment (aMCI) and/or dementia. Subjective cognitive decline (SCD) is characterized by self-experienced memory decline without any evidence of objective cognitive decline and is regarded as the later stage of preclinical AD. It has been reported that the changes in structural covariance patterns are affected by AD pathology in the patients with AD and aMCI within the specific large-scale brain networks. However, the changes in structural covariance patterns including normal control (NC), SCD, aMCI, and AD are still poorly understood. In this study, we recruited 42 NCs, 35 individuals with SCD, 43 patients with aMCI, and 41 patients with AD. Gray matter (GM) volumes were extracted from 10 readily identifiable regions of interest involved in high-order cognitive function and AD-related dysfunctional structures. The volume values were used to predict the regional densities in the whole brain by using voxel-based statistical and multiple linear regression models. Decreased structural covariance and weakened connectivity strength were observed in individuals with SCD compared with NCs. Structural covariance networks (SCNs) seeding from the default mode network (DMN), salience network, subfields of the hippocampus, and cholinergic basal forebrain showed increased structural covariance at the early stage of AD (referring to aMCI) and decreased structural covariance at the dementia stage (referring to AD). Moreover, the SCN seeding from the executive control network (ECN) showed a linearly increased extent of the structural covariance during the early and dementia stages. The results suggest that changes in structural covariance patterns as the order of NC-SCD-aMCI-AD are divergent and dynamic, and support the structural disconnection hypothesis in individuals with SCD.

scholarly journals Use of an Alzheimer's Disease-Related Hypometabolic Convergence Index to Predict Progression from Mild Cognitive Impairment to Alzheimer's Dementia

2010 ◽  
Vol 6 (4) ◽  
pp. S296
Author(s):  
Kewei Chen ◽  
Napatkamon Ayutyanont ◽  
Jessica Langbaum ◽  
Adam Fleisher ◽  
Cole Reschke ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia

scholarly journals Anosognosia in Amnestic Mild Cognitive Impairment Is Related to Diminished Hippocampal Volume Comparable to Alzheimer’s Disease Dementia: Preliminary MRI Findings

2021 ◽  
Vol 13 ◽  
Author(s):  
Juan Francisco Flores-Vázquez ◽  
Gabriel Ramírez-García ◽  
Oscar René Marrufo-Meléndez ◽  
Ruth Alcalá-Lozano ◽  
Morten Peter Lietz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Gray Matter ◽  
Mean Diffusivity ◽  
Amnestic Mild Cognitive Impairment ◽  
Matter Density ◽  
Mri Findings ◽  
Gray Matter Density

Although the presence of anosognosia in amnestic mild cognitive impairment (aMCI) may be predictive of conversion to Alzheimer’s disease (AD), little is known about its neural correlates in AD and aMCI. Four different groups were compared using volumetric and diffusion magnetic resonance imaging metrics in regions of interest (hippocampus and cingulum cortex gray matter, cingulum bundle white matter): aMCI subjects with anosognosia (n = 6), aMCI subjects without anosognosia (n = 12), AD subjects with anosognosia (n = 6), and AD subjects without anosognosia (n = 9). aMCI subjects with anosognosia displayed a significantly lower gray matter density (GMD) in the bilateral hippocampus than aMCI subjects without anosognosia, which was accounted for by bilateral hippocampal differences. Furthermore, we identified that the mean hippocampal gray matter density of aMCI subjects with anosognosia was not statistically different than that of AD subjects. The groups of aMCI and AD subjects with anosognosia also displayed a lower GMD in the bilateral cingulum cortex compared to subjects without anosognosia, but these differences were not statistically significant. No statistically significant differences were found in the fractional anisotropy or mean diffusivity of the hippocampus or cingulum between subjects with and without anosognosia in aMCI or AD groups. While these findings are derived from a small population of subjects and are in need of replication, they suggest that anosognosia in aMCI might be a useful clinical marker to suspect brain changes associated with AD neuropathology.

IC-P-019: Voxel-based morphometry of amnestic mild cognitive impairment and Alzheimer's disease

2009 ◽  
Vol 5 (4S_Part_1) ◽  
pp. P12-P13
Author(s):  
Yi He ◽  
Mei-Yan Zhang ◽  
Kevin Head ◽  
Daniel Chang ◽  
Huishu Yuan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Voxel Based Morphometry
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