P4-176: Proteomics determined glycoproteome in mild cognitive impairment, early Alzheimer's disease, and late-stage Alzheimer's disease hippocampus and inferior parietal lobule

2008 ◽  
Vol 4 ◽  
pp. T722-T722
Author(s):  
Joshua B. Owen ◽  
Fabio Dominico ◽  
Marzia Perluigi ◽  
Rukhsana Sultana ◽  
D. Allan Butterfield
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Late Stage ◽  
Inferior Parietal Lobule ◽  
Parietal Lobule ◽  
Early Alzheimer’S Disease

Increase of EEG Alpha3/Alpha2 Power Ratio Detects Inferior Parietal Lobule Atrophy in Mild Cognitive Impairment

2018 ◽  
Vol 15 (5) ◽  
pp. 443-451
Author(s):  
Davide V. Moretti
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Clinical Feature ◽  
Power Ratio ◽  
Inferior Parietal Lobule ◽  
Mri Scans ◽  
Parietal Lobule ◽  
Early Alzheimer’S Disease

Objective: The inferior parietal lobule (IPL) has been implicate in many higher cognitive processes, as visuo-motor transformations, tool use or tool making. In subjects with mild cognitive impairment (MCI) at major risk to develop Alzheimer' Disease (AD) an impairment of subtle visuomotor or praxic abilities is a well-known clinical feature. Enhance of the ratio of EEG alpha3/alpha2 frequency power was detected in subjects with MCI who will transform in Alzheimer's disease (AD). Methods: We explored of the association of alpha3/alpha2 power ratio with cortical size of IPL in patients with MCI. 74 subjects with MCI undergone EEG recording and MRI scans. Alpha3/alpha2 power ratio in addition to cortical size had been computed for each patient. Three MCI groups had been acquired in keeping with growing tertile values of alpha3/alpha2 ratio. Huge difference of cortical thickness among the groups was calculated. Higher alpha3/alpha2 power ratio group had broader cortical loss compared to other teams on the IPL, particularly in the Supramarginal Gyrus, and Precuneus on both hemispheres. Results: Our results unveil the possible part that the IPL could play in determining the classic alterations of early Alzheimer's disease (AD). Conclusion: Finally, the rise of alpha3/alpha2 power ratio detected a focused anatomo-functional association that could be a reliable marker of incipient AD.

Rates of progression in mild cognitive impairment and early Alzheimer's disease

Neurology ◽  
2002 ◽  
Vol 59 (7) ◽  
pp. 1034-1041 ◽  
Author(s):  
M. Storandt ◽  
E. A. Grant ◽  
J. P. Miller ◽  
J. C. Morris
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Alzheimer’S Disease

scholarly journals Studies of implicit prototype extraction in patients with mild cognitive impairment and early Alzheimer's disease.

2012 ◽  
Vol 38 (4) ◽  
pp. 860-880 ◽  
Author(s):  
Robert M. Nosofsky ◽  
Stephen E. Denton ◽  
Safa R. Zaki ◽  
Anne F. Murphy-Knudsen ◽  
Frederick W. Unverzagt
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Alzheimer’S Disease

scholarly journals Proteomic identification of nitrated brain proteins in early Alzheimer’s disease inferior parietal lobule

2008 ◽  
Vol 13 (8b) ◽  
pp. 2019-2029 ◽  
Author(s):  
Tanea T. Reed ◽  
William M. Pierce Jr. ◽  
Delano M. Turner ◽  
William R. Markesbery ◽  
D. Allan Butterfield
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Inferior Parietal Lobule ◽  
Brain Proteins ◽  
Proteomic Identification ◽  
Parietal Lobule ◽  
Early Alzheimer’S Disease

Diagnostic utility of sound naming in early Alzheimer’s disease

2009 ◽  
Vol 15 (2) ◽  
pp. 231-238 ◽  
Author(s):  
HYEON-AE JEON ◽  
KYOUNG-MIN LEE
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Picture Naming ◽  
Temporal Cortex ◽  
Cognitive Domain ◽  
Diagnostic Utility ◽  
Future Studies ◽  
Early Alzheimer’S Disease

AbstractWhile it is well known that picture naming (PN) is impaired in Alzheimer’s disease (AD), sound naming (SN) has not been thoroughly investigated. We postulated that SN might be impaired more severely and earlier than PN, given the early involvement of the temporal cortex by AD-related pathology. SN and PN were assessed in 21 normal participants, 40 patients with mild cognitive impairment (MCI), and 27 patients in early stages of AD. Our results showed that SN accuracy and latency were more sensitive to advancing pathology in AD than PN accuracy and latency. SN was more useful and specific in distinguishing MCI patients from normal participants and therefore in potentially identifying the subset of MCI patients who already have impairment in more than one cognitive domain and may actually have incipient AD. These findings indicate a potential diagnostic utility of SN for early detection of the disease. Furthermore, even though most AD patients demonstrated more or less comparable impairment in both tasks, some were disproportionately impaired on SN and others were differentially impaired on PN. Future studies may be able to show that these discrepant groups correspond to patients with right and left hemisphere predominant AD, respectively. (JINS, 2009, 15, 231–238.)

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