Objective: The inferior parietal lobule (IPL) has been implicate in many higher cognitive
processes, as visuo-motor transformations, tool use or tool making. In subjects with mild cognitive impairment
(MCI) at major risk to develop Alzheimer' Disease (AD) an impairment of subtle visuomotor or
praxic abilities is a well-known clinical feature. Enhance of the ratio of EEG alpha3/alpha2 frequency
power was detected in subjects with MCI who will transform in Alzheimer's disease (AD).
Methods:
We explored of the association of alpha3/alpha2 power ratio with cortical size of IPL in patients
with MCI. 74 subjects with MCI undergone EEG recording and MRI scans. Alpha3/alpha2 power
ratio in addition to cortical size had been computed for each patient. Three MCI groups had been acquired
in keeping with growing tertile values of alpha3/alpha2 ratio. Huge difference of cortical thickness
among the groups was calculated. Higher alpha3/alpha2 power ratio group had broader cortical loss compared
to other teams on the IPL, particularly in the Supramarginal Gyrus, and Precuneus on both hemispheres.
Results:
Our results unveil the possible part that the IPL could play in determining the classic alterations
of early Alzheimer's disease (AD).
Conclusion:
Finally, the rise of alpha3/alpha2 power ratio detected a focused anatomo-functional association
that could be a reliable marker of incipient AD.
Proteomic identification of nitrated brain proteins in early Alzheimer’s disease inferior parietal lobule
