P1-134: Magnetic Resonance Spectroscopy (MRS) analysis in Alzheimer's disease - a novel approach for integrating metabolite spectra, tissue segmentation and perfusion data

2009 ◽  
Vol 5 (4S_Part_7) ◽  
pp. P216-P216
Author(s):  
Gregory Szilagyi ◽  
Christopher J.M. Scott ◽  
Sofia Chavez ◽  
Sandra E. Black
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Tissue Segmentation ◽  
Novel Approach

scholarly journals Proton and Phosphorus Magnetic Resonance Spectroscopy of a Mouse Model of Alzheimer's Disease

2012 ◽  
Vol 31 (s3) ◽  
pp. S87-S99 ◽  
Author(s):  
Vladimír Mlynárik ◽  
Matthias Cacquevel ◽  
Lili Sun-Reimer ◽  
Sharon Janssens ◽  
Cristina Cudalbu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Mouse Model ◽  
Resonance Spectroscopy ◽  
Phosphorus Magnetic Resonance Spectroscopy ◽  
Model Of Alzheimer’S Disease

scholarly journals The Profile of Hippocampal Metabolites Differs between Alzheimer's Disease and Subcortical Ischemic Vascular Dementia, as Measured by Proton Magnetic Resonance Spectroscopy

2012 ◽  
Vol 32 (5) ◽  
pp. 805-815 ◽  
Author(s):  
Akihiko Shiino ◽  
Toshiyuki Watanabe ◽  
Yoshitomo Shirakashi ◽  
Emi Kotani ◽  
Masahiro Yoshimura ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Vascular Dementia ◽  
Characteristic Curve ◽  
Elderly Subjects ◽  
Resonance Spectroscopy ◽  
Concentration Changes

Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SIVD) have overlapping pathologies and risk factors, but their underlying neurodegenerative mechanisms are basically different. We performed magnetic resonance spectroscopy (MRS) to study metabolite differences between the two diseases in vivo. The subjects were 31 patients with SIVD and 99 with AD. Additionally, 45 elderly subjects were recruited as controls. We measured N-acetylaspartate (NAA), glutamine and glutamate (Glx), and myoinositol (mIns) concentration quantitatively using a 1.5-T MR scanner. N-acetylaspartate and Glx concentrations decreased in the hippocampus and cingulate/precuneal cortices (PCC) in both AD and SIVD patients, and the NAA decrease in the hippocampus was more prominent in AD than in SIVD. Interestingly, the pattern of mIns concentration changes differed between the two disorders; mIns was increased in AD but not increased in SIVD. If one differentiates between AD and SIVD by the mIns concentration in the hippocampus, the area under the receiver operating characteristic curve was 0.95, suggesting a high potential for discrimination. Our results suggest that proton MRS can provide useful information to differentiate between AD and SIVD. The difference of mIns concentrations in the hippocampus and PCC seems to reflect the different neurodegenerative mechanisms of the two disorders.

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