P3-091: Ambulatory blood pressure and cognitive function in nondemented older adults: Findings of the maracaibo aging study

2010 ◽  
Vol 6 ◽  
pp. S477-S477 ◽  
Author(s):  
Carmen A. Gonzalez-Rojas ◽  
Gloria Pino-Ramirez ◽  
Angelica G. Partida ◽  
Egle R. Silva ◽  
Gladys E. Maestre
2015 ◽  
Vol 28 (12) ◽  
pp. 1444-1452 ◽  
Author(s):  
Kyle S. Conway ◽  
Nketi Forbang ◽  
Tomasz Beben ◽  
Michael H. Criqui ◽  
Joachim H. Ix ◽  
...  

2022 ◽  
Vol 50 (1) ◽  
pp. 030006052110687
Author(s):  
Madeline R. Farron ◽  
Mohammed U. Kabeto ◽  
Deborah A. Levine ◽  
Caroline R. Wixom ◽  
Kenneth M. Langa

Objective We aimed to investigate the relationship between blood pressure and cognitive function among older adults in India. Methods In this study, we analyzed cross-sectional data of systolic and diastolic blood pressure (SBP and DBP, respectively) and cognitive testing from 3690 adults aged 60 years and older participating in the Longitudinal Aging Study in India—Diagnostic Assessment of Dementia from 14 states in India. Results After controlling for key sociodemographic, health, and geographic factors, higher SBP and lower DBP were each independently associated with worse cognitive function. Older age, female sex, lower education level, being widowed, residing in a rural area, being a member of a Scheduled Caste or Scheduled Tribe, having a low level of economic consumption, being underweight, and a history of stroke were all independently associated with worse cognitive function scores. Conclusions Both SBP and DBP were independently associated with cognitive function among older adults in India in diverging directions. Clinical interventions targeting high SBP and low DBP may benefit both cognitive health and cardiovascular health.


2005 ◽  
Vol 12 (3) ◽  
pp. 151
Author(s):  
F. Rabbia ◽  
C. Paglieri ◽  
C. Pugni ◽  
M. L. Genesia ◽  
J. Zhong ◽  
...  

Author(s):  
Mariana Barragán-García ◽  
Ricardo Ramírez-Aldana ◽  
Mariana López-Ortega ◽  
Sergio Sánchez-García ◽  
Carmen García-Peña

Drugs & Aging ◽  
2018 ◽  
Vol 35 (11) ◽  
pp. 993-1003 ◽  
Author(s):  
Maximilian König ◽  
Maik Gollasch ◽  
Adrian Rosada ◽  
Ilja Demuth ◽  
Dominik Spira ◽  
...  

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Bo Qin ◽  
Anthony J Viera ◽  
Linda S Adair ◽  
Brenda L Plassman ◽  
Lloyd J Edwards ◽  
...  

Introduction: Recent studies suggest higher visit-to-visit variability of blood pressure (BP) is associated with worse cognitive function, but evidence based on longitudinal cognitive testing has not been reported. Hypothesis: We assessed the hypothesis that higher visit-to-visit variability in BP, but not mean BP, would be associated with faster decline in cognitive function among community-dwelling older adults. Methods: This prospective cohort study comprised 1213 adults who had two or more waves of BP measurements as part of the China Health and Nutrition Survey from 1991, up to their first cognitive tests, and completed a cognitive screening test at two or more waves in 1997, 2000 or 2004. Mean (SD) age at first cognitive test was 64 (6) y. Outcomes were repeated measures of global cognitive scores (baseline mean ± SD: 19 ± 6 points), standardized composite cognitive and verbal memory scores (standardized units [SU]). Visit-to visit BP variability was expressed as the standard deviation [SD] or as the variation independent of mean (SD/mean^x, with x derived from curve fitting) in BP measures obtained at a mean interval of 3.6 years. Multivariable-adjusted linear mixed-effects models were used to determine the association of changes in cognitive scores with visit-to visit BP variability. Results: Higher visit-to-visit variability in systolic BP, but not mean systolic BP, was associated with a faster decline of cognitive function (adjusted mean difference [95% CI] for high vs. low tertile of SD in variability (Figure): global score -0.23 points/y [-0.41 to -0.04], composite scores -0.029 SU/y [-0.056 to -0.002] and verbal memory -0.044 SU/y [-0.075 to -0.012]). Higher visit-to-visit variability in diastolic BP was associated with a faster decline of global cognitive function only among adults 55-64 years, independent of mean diastolic BP. Conclusion: Higher long-term BP visit-to-visit variability predicted a faster rate of cognitive decline among older adults.


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