[P3-402]: PATIENTS WITH SUBJECTIVE COGNITIVE DECLINE AND AMYLOID PATHOLOGY EXHIBIT SIGNIFICANT BRAIN ATROPHY, TAU PATHOLOGY AND MILD MEMORY DIFFICULTIES

2017 ◽  
Vol 13 (7S_Part_23) ◽  
pp. P1117-P1117
Author(s):  
Olof Lindberg ◽  
Erik Stomrud ◽  
Oskar Hansson
Keyword(s):  
Cognitive Decline ◽  
Brain Atrophy ◽  
Subjective Cognitive Decline ◽  
Tau Pathology ◽  
Amyloid Pathology

IC-P-138: High CSF TAU is Related to Reduced Hippocampal Volume and Subjective Cognitive Decline in Healthy Elderly With Amyloid Pathology

2016 ◽  
Vol 12 ◽  
pp. P102-P103
Author(s):  
Alexa Pichet Binette ◽  
Jacob W. Vogel ◽  
Vladimir S. Fonov ◽  
Cécile Madjar ◽  
Jennifer Tremblay-Mercier ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Hippocampal Volume ◽  
Subjective Cognitive Decline ◽  
Amyloid Pathology ◽  
Healthy Elderly

O5-02-01: Brain and cognitive correlates of subjective cognitive decline differ between healthy elderly with and without β-amyloid pathology

2015 ◽  
Vol 11 (7S_Part_7) ◽  
pp. P315-P316
Author(s):  
Jacob W. Vogel ◽  
Monika Varga Doležalová ◽  
Renaud La Joie ◽  
Shawn Marks ◽  
Allison Fero ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Cognitive Correlates ◽  
Amyloid Pathology ◽  
Healthy Elderly ◽  
Β Amyloid

LONGITUDINAL DYNAMIC [18F]FLORTAUCIPIR PET REVEALS INCREASED EARLY STAGE TAU PATHOLOGY IN INDIVIDUALS WITH SUBJECTIVE COGNITIVE DECLINE

2019 ◽  
Vol 15 (7) ◽  
pp. P143-P144
Author(s):  
Denise Visser ◽  
Rik Ossenkoppele ◽  
Sander C.J. Verfaillie ◽  
Tessa Timmers ◽  
Emma E. Wolters ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Early Stage ◽  
Subjective Cognitive Decline ◽  
Tau Pathology ◽  
Longitudinal Dynamic

scholarly journals Brain myoinositol as a potential marker of amyloid-related pathology

Neurology ◽  
2019 ◽  
Vol 92 (5) ◽  
pp. e395-e405
Author(s):  
Olga Voevodskaya ◽  
Konstantinos Poulakis ◽  
Pia Sundgren ◽  
Danielle van Westen ◽  
Sebastian Palmqvist ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Rate Of Change ◽  
Longitudinal Change ◽  
Subjective Cognitive Decline ◽  
Resonance Spectroscopy ◽  
Multiple Time ◽  
Amyloid Pathology ◽  
Potential Marker

ObjectiveTo investigate the association between longitudinal changes in proton magnetic resonance spectroscopy (MRS) metabolites and amyloid pathology in individuals without dementia, and to explore the relationship between MRS and cognitive decline.MethodsIn this longitudinal multiple time point study (a subset of the Swedish BioFINDER), we included cognitively healthy participants, individuals with subjective cognitive decline, and individuals with mild cognitive impairment. MRS was acquired serially in 294 participants (670 individual spectra) from the posterior cingulate/precuneus. Using mixed-effects models, we assessed the association between MRS and baseline β-amyloid (Aβ), and between MRS and the longitudinal Mini-Mental State Examination, accounting for APOE, age, and sex.ResultsWhile baseline MRS metabolites were similar in Aβ positive (Aβ+) and negative (Aβ−) individuals, in the Aβ+ group, the estimated rate of change was +1.9%/y for myo-inositol (mI)/creatine (Cr) and −2.0%/y for N-acetylaspartate (NAA)/mI. In the Aβ− group, mI/Cr and NAA/mI yearly change was −0.05% and +1.2%; however, this was not significant across time points. The mild cognitive impairment Aβ+ group showed the steepest MRS changes, with an estimated rate of +2.93%/y (p = 0.07) for mI/Cr and −3.55%/y (p < 0.01) for NAA/mI. Furthermore, in the entire cohort, we found that Aβ+ individuals with low baseline NAA/mI had a significantly higher rate of cognitive decline than Aβ+ individuals with high baseline NAA/mI.ConclusionWe demonstrate that the longitudinal change in mI/Cr and NAA/mI is associated with underlying amyloid pathology. MRS may be a useful noninvasive marker of Aβ-related processes over time. In addition, we show that in Aβ+ individuals, baseline NAA/mI may predict the rate of future cognitive decline.

scholarly journals Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Lisa Miebach ◽  
Steffen Wolfsgruber ◽  
Alexandra Polcher ◽  
Oliver Peters ◽  
Felix Menne ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Amyloid Pathology

P4-353: SPECIFIC FEATURES OF SUBJECTIVE COGNITIVE DECLINE ARE RELATED TO AMYLOID AND TAU PATHOLOGY IN COGNITIVELY HEALTHY OLDER ADULTS

2019 ◽  
Vol 15 ◽  
pp. P1433-P1434
Author(s):  
Sietske A.M. Sikkes ◽  
Jennifer R. Gatchel ◽  
Rachel F. Buckley ◽  
Mark A. van de Wiel ◽  
Dorene M. Rentz ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Tau Pathology ◽  
Healthy Older Adults

scholarly journals P4-316: LONGITUDINAL DYNAMIC [18F]FLORTAUCIPIR PET REVEALS INCREASED EARLY STAGE TAU PATHOLOGY IN INDIVIDUALS WITH SUBJECTIVE COGNITIVE DECLINE

2019 ◽  
Vol 15 ◽  
pp. P1412-P1413
Author(s):  
Denise Visser ◽  
Rik Ossenkoppele ◽  
Sander C.J. Verfaillie ◽  
Tessa Timmers ◽  
Emma E. Wolters ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Early Stage ◽  
Subjective Cognitive Decline ◽  
Tau Pathology ◽  
Longitudinal Dynamic

P3-274: High CSF TAU is Related to Reduced Hippocampal Volume and Subjective Cognitive Decline in Healthy Elderly with Amyloid Pathology

2016 ◽  
Vol 12 ◽  
pp. P939-P940
Author(s):  
Alexa Pichet Binette ◽  
Jacob W. Vogel ◽  
Vladimir S. Fonov ◽  
Jennifer Tremblay-Mercier ◽  
Cécile Madjar ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Hippocampal Volume ◽  
Subjective Cognitive Decline ◽  
Amyloid Pathology ◽  
Healthy Elderly

scholarly journals Regional brain atrophy and cognitive decline depend on definition of subjective cognitive decline

2021 ◽  
pp. 102923
Author(s):  
Cassandra Morrison ◽  
Mahsa Dadar ◽  
Neda Shafiee ◽  
Sylvia Villeneuve ◽  
D. Louis Collins
Keyword(s):  
Cognitive Decline ◽  
Brain Atrophy ◽  
Subjective Cognitive Decline ◽  
Regional Brain ◽  
Definition Of ◽  
Regional Brain Atrophy
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