P2-605: EDUCATION, MIDDLE-AGE BODY MASS INDEX AND OLD AGE COGNITIVE FUNCTIONING: A POPULATION-BASED QUASI-EXPERIMENTAL TWIN STUDY

2006 ◽  
Vol 14 (7S_Part_18) ◽  
pp. P971-P971
Author(s):  
Eero Vuoksimaa ◽  
Noora Lindgren ◽  
Juha O. Rinne ◽  
Jaakko Kaprio
Keyword(s):  
Body Mass Index ◽  
Cognitive Functioning ◽  
Old Age ◽  
Body Mass ◽  
Twin Study ◽  
Middle Age ◽  
Population Based ◽  
Quasi Experimental

scholarly journals Middle-age dementia risk scores and old-age cognition: a quasi-experimental population-based twin study with over 20-year follow-up

2020 ◽  
pp. jnnp-2020-324009
Author(s):  
Paula Iso-Markku ◽  
Jaakko Kaprio ◽  
Noora Lindgren ◽  
Juha O Rinne ◽  
Eero Vuoksimaa
Keyword(s):  
Old Age ◽  
Middle Age ◽  
Twin Pair ◽  
Population Based ◽  
Self Report ◽  
Risk Scores ◽  
Experimental Population ◽  
Dementia Risk ◽  
Quasi Experimental ◽  
Intervention Trials

BackgroundMiddle-age risk scores predict cognitive impairment, but it is not known if these associations are evident when controlling for shared genetic and environmental factors. Using two risk scores, self-report educational-occupational score and Cardiovascular Risk Factors, Aging and Dementia (CAIDE), we investigated if twins with higher middle-age dementia risk have poorer old-age cognition compared with their co-twins with lower risk.MethodsWe used a population-based older Finnish Twin Cohort study with middle-age questionnaire data (n=15 169, mean age=52.0 years, SD=11.8) and old-age cognition measured via telephone interview (mean age=74.1, SD=4.1, n=4302). Between-family and within-family linear regression analyses were performed.ResultsIn between-family analyses (N=2359), higher educational-occupational score was related to better cognition (B=0.76, 95% CI 0.69 to 0.83) and higher CAIDE score was associated with poorer cognition (B=−0.73, 95% CI −0.82 to -0.65). Within twin-pair differences in educational-occupational score were significantly related to within twin-pair differences in cognition in dizygotic (DZ) pairs (B=0.78, 95% CI 0.25 to 1.31; N=338) but not in monozygotic (MZ) pairs (B=0.12, 95% CI −0.44 to 0.68; N=221). Within twin-pair differences in CAIDE score were not related to within twin-pair differences in cognition: DZ B=−0.38 (95% CI −0.90 to 0.14, N=343) and MZ B=−0.05 (95% CI −0.59 to 0.49; N=226).ConclusionMiddle-age dementia risk scores predicted old-age cognition, but within twin-pair analyses gave little support for associations independent of shared environmental and genetic factors. Understanding genetic underpinnings of risk score−cognition associations is important for early detection of dementia and designing intervention trials.

scholarly journals Life-course trajectories of body mass index from adolescence to old age: Racial and educational disparities

2021 ◽  
Vol 118 (17) ◽  
pp. e2020167118
Author(s):  
Yang Claire Yang ◽  
Christine E. Walsh ◽  
Moira P. Johnson ◽  
Daniel W. Belsky ◽  
Max Reason ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Educational Attainment ◽  
Life Course ◽  
Old Age ◽  
Body Mass ◽  
Parental Education ◽  
Population Based ◽  
Birth Cohorts ◽  
Bmi Trajectories ◽  
The Life Course

No research exists on how body mass index (BMI) changes with age over the full life span and social disparities therein. This study aims to fill the gap using an innovative life-course research design and analytic methods to model BMI trajectories from early adolescence to old age across 20th-century birth cohorts and test sociodemographic variation in such trajectories. We conducted the pooled integrative data analysis (IDA) to combine data from four national population-based NIH longitudinal cohort studies that collectively cover multiple stages of the life course (Add Health, MIDUS, ACL, and HRS) and estimate mixed-effects models of age trajectories of BMI for men and women. We examined associations of BMI trajectories with birth cohort, race/ethnicity, parental education, and adult educational attainment. We found higher mean levels of and larger increases in BMI with age across more recent birth cohorts as compared with earlier-born cohorts. Black and Hispanic excesses in BMI compared with Whites were present early in life and persisted at all ages, and, in the case of Black–White disparities, were of larger magnitude for more recent cohorts. Higher parental and adulthood educational attainment were associated with lower levels of BMI at all ages. Women with college-educated parents also experienced less cohort increase in mean BMI. Both race and education disparities in BMI trajectories were larger for women compared with men.

scholarly journals Cause-specific mortality in old age in relation to body mass index in middle age and in old age: follow-up of the Whitehall cohort of male civil servants

2005 ◽  
Vol 35 (1) ◽  
pp. 169-178 ◽  
Author(s):  
Elizabeth Breeze ◽  
Robert Clarke ◽  
Martin J Shipley ◽  
Michael G Marmot ◽  
Astrid E Fletcher
Keyword(s):  
Body Mass Index ◽  
Old Age ◽  
Body Mass ◽  
Middle Age ◽  
Civil Servants ◽  
Specific Mortality

1480: The Association of Body Mass Index and Serum Prostate Specific Antigen Levels in a Population-Based Study

2005 ◽  
Vol 173 (4S) ◽  
pp. 401-401
Author(s):  
Javier Hernandez ◽  
Jacques Baillargeon ◽  
Brad Pollock ◽  
Alan R. Kristal ◽  
Patrick Bradshaw ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Prostate Specific Antigen ◽  
Body Mass ◽  
Specific Antigen ◽  
Population Based ◽  
Population Based Study ◽  
Serum Prostate Specific Antigen

scholarly journals Trends in obesity and adiposity measures by race or ethnicity among adults in the United States 2011-18: population based study

BMJ ◽  
2021 ◽  
pp. n365
Author(s):  
Buyun Liu ◽  
Yang Du ◽  
Yuxiao Wu ◽  
Linda G Snetselaar ◽  
Robert B Wallace ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Waist Circumference ◽  
Ethnic Groups ◽  
Body Mass ◽  
Body Fat ◽  
Lean Mass ◽  
The United States ◽  
Population Based ◽  
Body Fat Percentage ◽  
Fat Percentage

AbstractObjectiveTo examine the trends in obesity and adiposity measures, including body mass index, waist circumference, body fat percentage, and lean mass, by race or ethnicity among adults in the United States from 2011 to 2018.DesignPopulation based study.SettingNational Health and Nutrition Examination Survey (NHANES), 2011-18.ParticipantsA nationally representative sample of US adults aged 20 years or older.Main outcome measuresWeight, height, and waist circumference among adults aged 20 years or older were measured by trained technicians using standardized protocols. Obesity was defined as body mass index of 30 or higher for non-Asians and 27.5 or higher for Asians. Abdominal obesity was defined as a waist circumference of 102 cm or larger for men and 88 cm or larger for women. Body fat percentage and lean mass were measured among adults aged 20-59 years by using dual energy x ray absorptiometry.ResultsThis study included 21 399 adults from NHANES 2011-18. Body mass index was measured for 21 093 adults, waist circumference for 20 080 adults, and body fat percentage for 10 864 adults. For the overall population, age adjusted prevalence of general obesity increased from 35.4% (95% confidence interval 32.5% to 38.3%) in 2011-12 to 43.4% (39.8% to 47.0%) in 2017-18 (P for trend<0.001), and age adjusted prevalence of abdominal obesity increased from 54.5% (51.2% to 57.8%) in 2011-12 to 59.1% (55.6% to 62.7%) in 2017-18 (P for trend=0.02). Age adjusted mean body mass index increased from 28.7 (28.2 to 29.1) in 2011-12 to 29.8 (29.2 to 30.4) in 2017-18 (P for trend=0.001), and age adjusted mean waist circumference increased from 98.4 cm (97.4 to 99.5 cm) in 2011-12 to 100.5 cm (98.9 to 102.1 cm) in 2017-18 (P for trend=0.01). Significant increases were observed in body mass index and waist circumference among the Hispanic, non-Hispanic white, and non-Hispanic Asian groups (all P for trend<0.05), but not for the non-Hispanic black group. For body fat percentage, a significant increase was observed among non-Hispanic Asians (30.6%, 29.8% to 31.4% in 2011-12; 32.7%, 32.0% to 33.4% in 2017-18; P for trend=0.001), but not among other racial or ethnic groups. The age adjusted mean lean mass decreased in the non-Hispanic black group and increased in the non-Hispanic Asian group, but no statistically significant changes were found in other racial or ethnic groups.ConclusionsAmong US adults, an increasing trend was found in obesity and adiposity measures from 2011 to 2018, although disparities exist among racial or ethnic groups.

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