F2-02-02: NEUROFILAMENT LIGHT CHAIN AS A BIOMARKER FOR FRONTOTEMPORAL LOBAR DEGENERATION

2006 ◽  
Vol 14 (7S_Part_11) ◽  
pp. P603-P604
Author(s):  
Adam L. Boxer ◽  
Julio C. Rojas ◽  
Keyword(s):  
Light Chain ◽  
Frontotemporal Lobar Degeneration ◽  
Neurofilament Light Chain ◽  
Neurofilament Light

scholarly journals ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration

2020 ◽  
Author(s):  
Katheryn A.Q. Cousins ◽  
Jeffrey S. Phillips ◽  
David J. Irwin ◽  
Edward B. Lee ◽  
David A. Wolk ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Light Chain ◽  
Frontotemporal Lobar Degeneration ◽  
Neurofilament Light Chain ◽  
Neurofilament Light

scholarly journals Neurofilament Light Chain Is Related to Longitudinal Decline in Frontotemporal Lobar Degeneration

2021 ◽  
pp. 10.1212/CPJ.0000000000001133
Keyword(s):  
Light Chain ◽  
Frontotemporal Lobar Degeneration ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
The Third ◽  
Research Article

In the Research article “Neurofilament Light Chain Is Related to Longitudinal Decline in Frontotemporal Lobar Degeneration” by Zhang et al.1, the data in the third column of Table 4 labeled “F letter fluency” were incorrect. A corrected Table 4 is below. The authors regret the error.

scholarly journals Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders

2019 ◽  
Vol 267 (1) ◽  
pp. 162-167 ◽  
Author(s):  
Kasper Katisko ◽  
Antti Cajanus ◽  
Olli Jääskeläinen ◽  
Aleksi Kontkanen ◽  
Päivi Hartikainen ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Single Molecule ◽  
Light Chain ◽  
Frontotemporal Lobar Degeneration ◽  
Psychotic Disorders ◽  
Late Onset ◽  
Single Subject ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Csf Levels

Abstract Due to the significant clinical overlap between frontotemporal lobar degeneration (FTLD) spectrum disorders and late-onset primary psychiatric disorders (PPD), diagnostic biomarkers reflecting the different underlying pathophysiologies are urgently needed. Thus far, elevated cerebrospinal fluid (CSF) levels of neurofilament light chain (NfL) have been reported in various neurological conditions. Furthermore, recent advancements in ultrasensitive analytical methods (e.g., single molecule array, Simoa) have enabled sensitive and less invasive NfL detection also from blood samples. In this study, we evaluated the potential of serum NfL (sNfL) as a diagnostic tool between FTLD and PPD. We analyzed sNfL levels with Simoa from 125 participants including patients from FTLD (n = 91) and PPD (n = 34) spectra. Our results show that sNfL levels are higher in the FTLD group compared to the PPD group as well as in separate clinical subtypes of FTLD compared to different psychiatric manifestations (i.e., mood or psychotic disorders). At single-subject level, discrimination between FTLD and PPD was possible with 80% sensitivity and 85% specificity (AUC = 0.850, 95% CI 0.776–0.923), and between behavioral variant frontotemporal dementia (bvFTD) and PPD with 79% sensitivity and 85% specificity (AUC = 0.830, 95% CI 0.732–0.908). These findings highlight the potential of sNfL as a discriminating biomarker for FTLD over PPD in patients with wide-ranging behavioral, psychiatric and cognitive symptoms.

scholarly journals Plasma neurofilament light chain levels reflect caregiver burden and social cognition measures in familial frontotemporal lobar degeneration (FTLD)

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Hilary W. Heuer ◽  
Julio C. Rojas ◽  
Gianina Toller ◽  
Katherine Rankin ◽  
Danielle Brushaber ◽  
...  
Keyword(s):  
Social Cognition ◽  
Caregiver Burden ◽  
Light Chain ◽  
Frontotemporal Lobar Degeneration ◽  
Neurofilament Light Chain ◽  
Neurofilament Light

scholarly journals Neurofilament light chain related to longitudinal decline in frontotemporal lobar degeneration

2020 ◽  
pp. 10.1212/CPJ.0000000000000959
Author(s):  
Jiasi Vicky Zhang ◽  
David J. Irwin ◽  
Kaj Blennow ◽  
Henrik Zetterberg ◽  
Edward B. Lee ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Light Chain ◽  
Frontotemporal Lobar Degeneration ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Cognitive Domains ◽  
Diagnosis And Prognosis ◽  
Language Measures ◽  
Disease Modifying Treatment

ABSTRACTBackground:Accurate diagnosis and prognosis of frontotemporal lobar degeneration (FTLD) during life is an urgent concern in the context of emerging disease-modifying treatment trials. Few cerebrospinal fluid (CSF) markers have been validated longitudinally in patients with known pathology, and we hypothesized that CSF neurofilament light chain (NfL) would be associated with longitudinal cognitive decline in patients with known FTLD-TDP pathology.Methods:This case-control study evaluated CSF NfL, total-tau (tTau), phosphorylated-tau (pTau) and beta-amyloid (Aβ42) in known FTLD-Tau or FTLD-TDP pathology (n=50) and healthy controls (n=65), and an extended cohort of clinically-diagnosed patients with likely FTLD-Tau or FTLD-TDP (n=148). Regression analyses related CSF analytes to longitudinal cognitive decline (follow up ∼1 year), controlling for demographic variables and core AD CSF analytes.Results:In FTLD-TDP with known pathology, CSF NfL is significantly elevated compared to controls, and significantly associated with longitudinal decline on specific executive and language measures, after controlling for age, disease duration, and core AD CSF analytes. Similar findings are found in the extended cohort also including clinically-identified likely FTLD-TDP. While CSF NfL is elevated in FTLD-Tau compared to controls, the association between NfL and longitudinal cognitive decline is limited to executive measures.Conclusion:CSF NfL is associated with longitudinal clinical decline in relevant cognitive domains in patients with FTLD-TDP after controlling for demographic factors and core AD CSF analytes, and may also be related to longitudinal decline in executive functioning in FTLD-Tau.

Biological Variation of Serum Neurofilament Light Chain in Healthy Subjects

2020 ◽  
Author(s):  
Claus Vinter Bødker Hviid ◽  
Anne Tranberg Madsen ◽  
Anne Winther-Larsen
Keyword(s):  
Light Chain ◽  
Healthy Subjects ◽  
Biological Variation ◽  
Neurofilament Light Chain ◽  
Neurofilament Light
Sign in / Sign up

Export Citation Format

Share Document