P1-469: PET IMAGING OF METABOTROPIC GLUTAMATE RECEPTOR 5 BINDING IN ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_9) ◽  
pp. P501-P503 ◽  
Author(s):  
Adam P. Mecca ◽  
Julia W. McDonald ◽  
Hannah R. Michalak ◽  
Tyler Godek ◽  
Joanna Harris ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glutamate Receptor ◽  
Pet Imaging ◽  
Metabotropic Glutamate Receptor ◽  
Metabotropic Glutamate Receptor 5 ◽  
Metabotropic Glutamate

IC-04-03: PET IMAGING OF METABOTROPIC GLUTAMATE RECEPTOR 5 BINDING IN ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_1) ◽  
pp. P8-P9
Author(s):  
Adam P. Mecca ◽  
Julia W. McDonald ◽  
Hannah R. Michalak ◽  
Tyler Godek ◽  
Joanna Harris ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glutamate Receptor ◽  
Pet Imaging ◽  
Metabotropic Glutamate Receptor ◽  
Metabotropic Glutamate Receptor 5 ◽  
Metabotropic Glutamate

scholarly journals Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease

2014 ◽  
Vol 7 (1) ◽  
pp. 40 ◽  
Author(s):  
Alison Hamilton ◽  
Jessica L Esseltine ◽  
Rebecca A DeVries ◽  
Sean P Cregan ◽  
Stephen S G Ferguson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mouse Model ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Metabotropic Glutamate Receptor 5 ◽  
Metabotropic Glutamate ◽  
Model Of Alzheimer’S Disease

scholarly journals Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer’s disease

Brain ◽  
2015 ◽  
Vol 139 (2) ◽  
pp. 526-546 ◽  
Author(s):  
Laura T. Haas ◽  
Santiago V. Salazar ◽  
Mikhail A. Kostylev ◽  
Ji Won Um ◽  
Adam C. Kaufman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prion Protein ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Cellular Prion Protein ◽  
Intracellular Signalling ◽  
Metabotropic Glutamate Receptor 5 ◽  
Metabotropic Glutamate

Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease

2021 ◽  
Vol 62 (1) ◽  
Author(s):  
Khaled S. Abd-Elrahman ◽  
Stephen S.G. Ferguson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glutamate Receptor ◽  
Therapeutic Target ◽  
Metabotropic Glutamate Receptor ◽  
Cellular Prion Protein ◽  
Publication Date ◽  
Pathophysiological Mechanism ◽  
Metabotropic Glutamate Receptor 5 ◽  
Metabotropic Glutamate

Metabotropic glutamate receptor 5 (mGluR5) is ubiquitously expressed in brain regions responsible for memory and learning. It plays a key role in modulating rapid changes in synaptic transmission and plasticity. mGluR5 supports long-term changes in synaptic strength by regulating the transcription and translation of essential synaptic proteins. β-Amyloid 42 (Aβ42) oligomers interact with a mGluR5/cellular prion protein (PrPC) complex to disrupt physiological mGluR5 signal transduction. Aberrant mGluR5 signaling and associated synaptic failure are considered an emerging pathophysiological mechanism of Alzheimer's disease (AD). Therefore, mGluR5 represents an attractive therapeutic target for AD, and recent studies continue to validate the efficacy of various mGluR5 allosteric modulators in improving memory deficits and mitigating disease pathology. However, sex-specific differences in the pharmacology of mGluR5 and activation of noncanonical signaling downstream of the receptor suggest that its utility as a therapeutic target in female AD patients needs to be reconsidered. Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 62 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

P2-022: Declines of hippocampal metabotropic glutamate receptor in Alzheimer's disease

2009 ◽  
Vol 5 (4S_Part_9) ◽  
pp. P267-P267
Author(s):  
Luciano Minuzzi ◽  
Remi Quirion ◽  
Serge Gauthier ◽  
Pedro Rosa-Neto
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Metabotropic Glutamate

Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease

2013 ◽  
Vol 127 (3) ◽  
pp. 415-425 ◽  
Author(s):  
Valeriy G. Ostapchenko ◽  
Flavio H. Beraldo ◽  
Andre L. S. Guimarães ◽  
Sanju Mishra ◽  
Monica Guzman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Prion Protein ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Protein Processing ◽  
Metabotropic Glutamate ◽  
Model Of Alzheimer’S Disease ◽  
Metabotropic Glutamate Receptor 1

Brain 11 C‐ITMM PET to longitudinally assess type 1 metabotropic glutamate receptor availability in Alzheimer's disease

2021 ◽  
Author(s):  
Kenji Ishibashi ◽  
Yoshiharu Miura ◽  
Kei Wagatsuma ◽  
Masashi Kameyama ◽  
Kenji Ishii
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Metabotropic Glutamate

scholarly journals Preclinical Evaluation and Quantification of 18F-FPEB as a Radioligand for PET Imaging of the Metabotropic Glutamate Receptor 5

2015 ◽  
Vol 56 (12) ◽  
pp. 1954-1959 ◽  
Author(s):  
B. de Laat ◽  
G. Leurquin-Sterk ◽  
S. Celen ◽  
G. Bormans ◽  
M. Koole ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Pet Imaging ◽  
Metabotropic Glutamate Receptor ◽  
Metabotropic Glutamate Receptor 5 ◽  
Preclinical Evaluation ◽  
Metabotropic Glutamate
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