Valproic acid attenuates platelet dysfunction, endothelial glycocalyx shedding and protein C activation in a porcine model of traumatic brain injury and shock

2013 ◽  
Vol 217 (3) ◽  
pp. S51 ◽  
Author(s):  
Martin Sillesen ◽  
Per I. Johansson ◽  
Lars S. Rasmussen ◽  
Guang Jin ◽  
Cecilie H. Jepsen ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Protein C ◽  
Porcine Model ◽  
Endothelial Glycocalyx ◽  
Platelet Dysfunction

Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock

2018 ◽  
Vol 228 ◽  
pp. 84-92 ◽  
Author(s):  
Michael Weykamp ◽  
Vahagn C. Nikolian ◽  
Isabel S. Dennahy ◽  
Gerald A. Higgins ◽  
Patrick E. Georgoff ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Porcine Model

Valproic acid increases endothelial glycocalyx shedding and decreases lesion size volume in a rodent model of severe isolated traumatic brain injury

2013 ◽  
Vol 217 (3) ◽  
pp. S32 ◽  
Author(s):  
Cecilie H. Jepsen ◽  
Pär I. Johansson ◽  
Anders Perner ◽  
Martin H. Sillesen ◽  
Hasan B. Alam ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Lesion Size ◽  
Rodent Model ◽  
Endothelial Glycocalyx

Effect of valproic acid and injury on lesion size and endothelial glycocalyx shedding in a rodent model of isolated traumatic brain injury

2014 ◽  
Vol 77 (2) ◽  
pp. 292-297 ◽  
Author(s):  
Cecilie Heerdegen Jepsen ◽  
Marc A. deMoya ◽  
Anders Perner ◽  
Martin Sillesen ◽  
Sisse R. Ostrowski ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Lesion Size ◽  
Rodent Model ◽  
Endothelial Glycocalyx

Valproic Acid Treatment Rapidly Modulates the Proteomic Profile in a Porcine Model of Hemorrhagic Shock and Traumatic Brain Injury

2017 ◽  
Vol 225 (4) ◽  
pp. S67
Author(s):  
Michael B. Weykamp ◽  
Vahagn C. Nikolian ◽  
Isabel S. Dennahy ◽  
Patrick E. Georgoff ◽  
Gerry A. Higgins ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Acid Treatment ◽  
Porcine Model ◽  
Proteomic Profile

scholarly journals Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock

2016 ◽  
Vol 33 (16) ◽  
pp. 1514-1521 ◽  
Author(s):  
Ted Bambakidis ◽  
Simone E. Dekker ◽  
Martin Sillesen ◽  
Baoling Liu ◽  
Craig N. Johnson ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Porcine Model ◽  
Inflammatory Genes

scholarly journals Experimental model of intracranial hypertension with continuous multiparametric monitoring in swine

2013 ◽  
Vol 71 (10) ◽  
pp. 802-806 ◽  
Author(s):  
Almir Ferreira de Andrade ◽  
Matheus Schmidt Soares ◽  
Gustavo Cartaxo Patriota ◽  
Alessandro Rodrigo Belon ◽  
Wellingson Silva Paiva ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Animal Model ◽  
Brain Injury ◽  
Intracranial Pressure ◽  
Intracranial Hypertension ◽  
Severe Traumatic Brain Injury ◽  
Transcranial Doppler ◽  
Porcine Model ◽  
Cerebral Oximetry ◽  
Suitable Animal Model

Objective Intracranial hypertension (IH) develops in approximately 50% of all patients with severe traumatic brain injury (TBI). Therefore, it is very important to identify a suitable animal model to study and understand the pathophysiology of refractory IH to develop effective treatments. Methods We describe a new experimental porcine model designed to simulate expansive brain hematoma causing IH. Under anesthesia, IH was simulated with a balloon insufflation. The IH variables were measured with intracranial pressure (ICP) parenchymal monitoring, epidural, cerebral oximetry, and transcranial Doppler (TCD). Results None of the animals died during the experiment. The ICP epidural showed a slower rise compared with parenchymal ICP. We found a correlation between ICP and cerebral oximetry. Conclusion The model described here seems useful to understand some of the pathophysiological characteristics of acute IH.

Valproic Acid Induces the NEUROD1 Transcriptional Program of Neurogenesis after Traumatic Brain Injury

2016 ◽  
Vol 223 (4) ◽  
pp. S160 ◽  
Author(s):  
Patrick E. Georgoff ◽  
Gerald Higgins ◽  
Vahagn C. Nikolian ◽  
Ted Bambakidis ◽  
Simone E. Dekker ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Transcriptional Program

Relationship of Coagulopathy and Platelet Dysfunction to Transfusion Needs After Traumatic Brain Injury

2018 ◽  
Vol 28 (3) ◽  
pp. 330-337 ◽  
Author(s):  
Grace Martin ◽  
Dhavan Shah ◽  
Nora Elson ◽  
Ryan Boudreau ◽  
Dennis Hanseman ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Platelet Dysfunction ◽  
Relationship Of

scholarly journals A Porcine Model of Traumatic Brain Injury via Head Rotational Acceleration

2016 ◽  
pp. 289-324 ◽  
Author(s):  
D. Kacy Cullen ◽  
James P. Harris ◽  
Kevin D. Browne ◽  
John A. Wolf ◽  
John E. Duda ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Porcine Model ◽  
Rotational Acceleration

Desmopressin is a transfusion sparing option to reverse platelet dysfunction in patients with severe traumatic brain injury

2020 ◽  
Vol 88 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Elisa J. Furay ◽  
Mitch J. Daley ◽  
Praveen Satarasinghe ◽  
Sabino Lara ◽  
Jayson D. Aydelotte ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Severe Traumatic Brain Injury ◽  
Platelet Dysfunction
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