scholarly journals A Porcine Model of Traumatic Brain Injury via Head Rotational Acceleration

2016 ◽  
pp. 289-324 ◽  
Author(s):  
D. Kacy Cullen ◽  
James P. Harris ◽  
Kevin D. Browne ◽  
John A. Wolf ◽  
John E. Duda ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Porcine Model ◽  
Rotational Acceleration

scholarly journals Experimental model of intracranial hypertension with continuous multiparametric monitoring in swine

2013 ◽  
Vol 71 (10) ◽  
pp. 802-806 ◽  
Author(s):  
Almir Ferreira de Andrade ◽  
Matheus Schmidt Soares ◽  
Gustavo Cartaxo Patriota ◽  
Alessandro Rodrigo Belon ◽  
Wellingson Silva Paiva ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Animal Model ◽  
Brain Injury ◽  
Intracranial Pressure ◽  
Intracranial Hypertension ◽  
Severe Traumatic Brain Injury ◽  
Transcranial Doppler ◽  
Porcine Model ◽  
Cerebral Oximetry ◽  
Suitable Animal Model

Objective Intracranial hypertension (IH) develops in approximately 50% of all patients with severe traumatic brain injury (TBI). Therefore, it is very important to identify a suitable animal model to study and understand the pathophysiology of refractory IH to develop effective treatments. Methods We describe a new experimental porcine model designed to simulate expansive brain hematoma causing IH. Under anesthesia, IH was simulated with a balloon insufflation. The IH variables were measured with intracranial pressure (ICP) parenchymal monitoring, epidural, cerebral oximetry, and transcranial Doppler (TCD). Results None of the animals died during the experiment. The ICP epidural showed a slower rise compared with parenchymal ICP. We found a correlation between ICP and cerebral oximetry. Conclusion The model described here seems useful to understand some of the pathophysiological characteristics of acute IH.

An examination of the current National Operating Committee on Standards for Athletic Equipment system and a new pneumatic ram method for evaluating American football helmet performance to reduce risk of concussion

2016 ◽  
Vol 231 (2) ◽  
pp. 83-90 ◽  
Author(s):  
Thomas Blaine Hoshizaki ◽  
Clara Karton ◽  
R. Anna Oeur ◽  
Marshall Kendall ◽  
Lauren Dawson ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Significant Risk ◽  
Standard Test ◽  
American Football ◽  
New Method ◽  
Rotational Acceleration ◽  
Football Helmets ◽  
Athletic Equipment ◽  
New System

Brain injuries are prevalent in the sport of American football. Helmets have been used which effectively have reduced the incidence of traumatic brain injury, but have had a limited effect on concussion rates. In an effort to improve the protective capacity of American football helmets, a standard has been proposed by National Operating Committee on Standards for Athletic Equipment that may better represent helmet-to-helmet impacts common to football concussions. The purpose of this research was to examine the National Operating Committee on Standards for Athletic Equipment standard and a new impact method similar to the proposed National Operating Committee on Standards for Athletic Equipment standard to examine the information these methods provide on helmet performance. Five National Operating Committee on Standards for Athletic Equipment–certified American football helmets were impacted according to the National Operating Committee on Standards for Athletic Equipment standard test and a new method based on the proposed standard test. The results demonstrated that the National Operating Committee on Standards for Athletic Equipment test produced larger linear accelerations than the new method, which were a reflection of the stiffer compliance of the standard meant to replicate traumatic brain injury mechanisms of injury. When the helmets were impacted using a new helmet-to-helmet method, the results reflected significant risk of concussive injury but showed differences in rotational acceleration responses between different helmet models. This suggests that the new system is sensitive enough to detect the effect of different design changes on rotational acceleration, a metric more closely associated with risk of concussion. As only one helmet produced magnitudes of response lower than the National Operating Committee on Standards for Athletic Equipment pass/fail using the new system, and all helmets passed the National Operating Committee on Standards for Athletic Equipment standard, these results suggest that further development of helmet technologies must be undertaken to reduce this risk in the future. Finally, these results show that it would be prudent to use both standards together to address risk of injury from traumatic brain injury and concussion.

scholarly journals Behavioral Outcomes Differ between Rotational Acceleration and Blast Mechanisms of Mild Traumatic Brain Injury

2016 ◽  
Vol 7 ◽  
Author(s):  
Brian D. Stemper ◽  
Alok S. Shah ◽  
Matthew D. Budde ◽  
Christopher M. Olsen ◽  
Aleksandra Glavaski-Joksimovic ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Behavioral Outcomes ◽  
Rotational Acceleration

Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock

2018 ◽  
Vol 228 ◽  
pp. 84-92 ◽  
Author(s):  
Michael Weykamp ◽  
Vahagn C. Nikolian ◽  
Isabel S. Dennahy ◽  
Gerald A. Higgins ◽  
Patrick E. Georgoff ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Porcine Model

scholarly journals Pathophysiological and behavioral deficits in developing mice following rotational acceleration-deceleration traumatic brain injury

2017 ◽  
Vol 11 (1) ◽  
pp. dmm030387 ◽  
Author(s):  
Guoxiang Wang ◽  
Yi Ping Zhang ◽  
Zhongwen Gao ◽  
Lisa B. E. Shields ◽  
Fang Li ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Rotational Acceleration ◽  
Behavioral Deficits ◽  
Developing Mice

High Versus Low Volume Fluid Resuscitation Strategies in a Porcine Model (Sus Scrofa) of Combined Thermal and Traumatic Brain Injury

Shock ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Timothy M. Guenther ◽  
Marguerite W. Spruce ◽  
Lindsey M. Bach ◽  
Connor M. Caples ◽  
Carl A. Beyer ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Fluid Resuscitation ◽  
Sus Scrofa ◽  
Porcine Model ◽  
Low Volume

Pharmacologic modulation of cerebral metabolic derangement and excitotoxicity in a porcine model of traumatic brain injury and hemorrhagic shock

Surgery ◽  
2013 ◽  
Vol 154 (2) ◽  
pp. 234-243 ◽  
Author(s):  
John O. Hwabejire ◽  
Guang Jin ◽  
Ayesha M. Imam ◽  
Michael Duggan ◽  
Martin Sillesen ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Porcine Model ◽  
Metabolic Derangement ◽  
Pharmacologic Modulation

The development of a threshold curve for the understanding of concussion in sport

Trauma ◽  
2016 ◽  
Vol 19 (3) ◽  
pp. 196-206 ◽  
Author(s):  
T Blaine Hoshizaki ◽  
Andrew Post ◽  
Marshall Kendall ◽  
Janie Cournoyer ◽  
Philippe Rousseau ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Narrow Range ◽  
Rotational Acceleration ◽  
Threshold Curve ◽  
Head Protection ◽  
Hybrid Iii ◽  
Tolerance Curve ◽  
Minor Traumatic Brain Injury ◽  
Standard Development

Much of what is known concerning human brain injury thresholds is based upon impacts to cadavers and animal models that were used to generate the Wayne State Concussion Tolerance Curve (WSTC) and similar curves. These curves are the foundation for predictive metrics used in standard development as well as helmet design. These curves were based upon a very narrow range of impacts; impacts whose characteristics differ greatly from how the head is impacted in sport. This research examines the uses of time-based curves like the WSTC in the context of understanding mechanisms of brain injury and head protection. Published linear/rotational acceleration magnitude/duration data from Hybrid III laboratory reconstructions of brain injury events were plotted. This research further develops the understanding of injury thresholds in comparison to threshold curves such as the WSTC and Brain Injury Curve Leuven. The data demonstrate the relationships between magnitude and duration of dynamic response on minor traumatic brain injury (mTBI) in sport.

Valproic Acid Treatment Rapidly Modulates the Proteomic Profile in a Porcine Model of Hemorrhagic Shock and Traumatic Brain Injury

2017 ◽  
Vol 225 (4) ◽  
pp. S67
Author(s):  
Michael B. Weykamp ◽  
Vahagn C. Nikolian ◽  
Isabel S. Dennahy ◽  
Patrick E. Georgoff ◽  
Gerry A. Higgins ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Acid Treatment ◽  
Porcine Model ◽  
Proteomic Profile
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