B-Lymphocyte Stimulator-Deficient Rats Prevent Donor-Specific Antibody Production and Proliferation in Rodent Model

2018 ◽  
Vol 227 (4) ◽  
pp. S251
Author(s):  
Natalie Bath ◽  
Bret Verhoven ◽  
Nancy A. Wilson ◽  
Shannon R. Reese ◽  
Sarah E. Panzer ◽  
...  
Keyword(s):  
Antibody Production ◽  
Specific Antibody ◽  
B Lymphocyte ◽  
Rodent Model ◽  
Specific Antibody Production ◽  
B Lymphocyte Stimulator

scholarly journals B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia

2011 ◽  
Vol 3 (4) ◽  
pp. 28 ◽  
Author(s):  
Annelieke A.A. Van der Linde ◽  
Ellen J.H. Schatorjé ◽  
Annemieke M. Van der Weij ◽  
Eugenie F.A. Gemen ◽  
Esther De Vries
Keyword(s):  
B Lymphocytes ◽  
Hemolytic Anemia ◽  
Antibody Production ◽  
Specific Antibody ◽  
Autoimmune Hemolytic Anemia ◽  
B Lymphocyte ◽  
Lymphocyte Subpopulations ◽  
Steroid Dependent ◽  
Specific Antibody Production

We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly normal directly after reconstitution. However, there was a slower reconstitution after the second rituximab course, especially of non-switched and switched memory B-lymphocytes, and a temporary decline in IgM below age-matched reference values.

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