Specific antibody production in herpes keratitis: intraocular inflammation and corneal neovascularisation as predicting factors

2005 ◽  
Vol 244 (2) ◽  
pp. 210-215 ◽  
Author(s):  
Pierre-Yves Robert ◽  
Anja Liekfeld ◽  
Sylvia Metzner ◽  
Sylvie Ranger-Rogez ◽  
Jean-Paul Adenis ◽  
...  
Keyword(s):  
Antibody Production ◽  
Specific Antibody ◽  
Intraocular Inflammation ◽  
Predicting Factors ◽  
Specific Antibody Production ◽  
Herpes Keratitis

Promotion of antigen-specific antibody production in murine B cells by a moderate increase in histone acetylation

1998 ◽  
Vol 56 (10) ◽  
pp. 1359-1364 ◽  
Author(s):  
Takashi Kohge ◽  
Eiichi Gohda ◽  
Takayuki Okamura ◽  
Itaru Yamamoto
Keyword(s):  
B Cells ◽  
Histone Acetylation ◽  
Antibody Production ◽  
Specific Antibody ◽  
Moderate Increase ◽  
Specific Antibody Production

HLA Donor Specific Antibody Production in ABO-Compatible Versus Incompatible Heart Transplant Recipients

2015 ◽  
Vol 34 (4) ◽  
pp. S327
Author(s):  
C. Chen ◽  
P. Warner ◽  
E.L. Albers ◽  
M.S. Kemna ◽  
L.C. Permut ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Antibody Production ◽  
Specific Antibody ◽  
Transplant Recipients ◽  
Specific Antibody Production ◽  
Heart Transplant Recipients

scholarly journals Transfer of antigen-encoding bone marrow under immune-preserving conditions deletes mature antigen-specific B cells in recipients and inhibits antigen-specific antibody production

Cytotherapy ◽  
2020 ◽  
Vol 22 (8) ◽  
pp. 436-444
Author(s):  
Jeremy F. Brooks ◽  
James E.M. Barber ◽  
Janet M. Davies ◽  
James W. Wells ◽  
Raymond J. Steptoe
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
Antibody Production ◽  
Specific Antibody ◽  
Specific Antibody Production

scholarly journals Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130

1997 ◽  
Vol 94 (6) ◽  
pp. 2478-2482 ◽  
Author(s):  
A. Kumanogoh ◽  
S. Marukawa ◽  
T. Kumanogoh ◽  
H. Hirota ◽  
K. Yoshida ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Antibody Production ◽  
Specific Antibody ◽  
Dominant Negative ◽  
Dominant Negative Form ◽  
Specific Antibody Production ◽  
Negative Form

scholarly journals Differential immunosuppressive activity of monoclonal CD2 antibodies on allograft rejection versus specific antibody production

1998 ◽  
Vol 28 (4) ◽  
pp. 1347-1357 ◽  
Author(s):  
Bernd Sido ◽  
Thomas J. Dengler ◽  
Gerd Otto ◽  
Rainer Zimmermann ◽  
Petra Müller ◽  
...  
Keyword(s):  
Antibody Production ◽  
Specific Antibody ◽  
Allograft Rejection ◽  
Immunosuppressive Activity ◽  
Specific Antibody Production

scholarly journals Deficiency of STING Promotes Collagen-Specific Antibody Production and B Cell Survival in Collagen-Induced Arthritis

2020 ◽  
Vol 11 ◽  
Author(s):  
Mookmanee Tansakul ◽  
Arthid Thim-uam ◽  
Thammakorn Saethang ◽  
Jiradej Makjaroen ◽  
Benjawan Wongprom ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Survival ◽  
Antibody Production ◽  
Specific Antibody ◽  
Collagen Induced Arthritis ◽  
B Cell Survival ◽  
Specific Antibody Production

scholarly journals Potentiating Antigen-Specific Antibody Production with Peptides Obtained from In Silico Screening for High-Affinity against MHC-II

Molecules ◽  
2019 ◽  
Vol 24 (16) ◽  
pp. 2949
Author(s):  
Yoshiro Hanyu ◽  
Yuto Komeiji ◽  
Mieko Kato
Keyword(s):  
Monoclonal Antibodies ◽  
Binding Affinity ◽  
Antibody Production ◽  
Specific Antibody ◽  
In Silico ◽  
Igg Antibody ◽  
Mhc Ii ◽  
High Affinity ◽  
Specific Antibody Production

Monoclonal antibodies with high affinity and specificity are essential for research and clinical purposes, yet remain difficult to produce. Agretope peptides that can potentiate antigen-specific antibody production have been reported recently. Here, we screened in silico for peptides with higher affinity against the agretope binding pocket in the MHC-II. The screening was based on the 3D crystal structure of a complex between MHC-II and a 14-mer peptide consisting of ovalbumin residues 323–339. Using this 14-mer peptide as template, we constructed a library of candidate peptides and screened for those that bound tightly to MHC-II. Peptide sequences that exhibited a higher binding affinity than the original ovalbumin peptide were identified. The peptide with the highest binding affinity was synthesized and its ability to boost antigen-specific antibody production in vivo and in vitro was assessed. In both cases, antigen-specific IgG antibody production was potentiated. Monoclonal antibodies were established by in vitro immunization using this peptide as immunostimulant, confirming the usefulness of such screened peptides for monoclonal antibody production.

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