As minimally invasive techniques in radiology suites become more common, the need for anesthesia support will increase. While recognizing and addressing a patient’s comorbidities and other concerns are similar to what is already done in the surgical setting, the additional requirements and constraints of the imaging environment and the procedure are unique and call for specific solutions. Just as in the operating room, there is frequently no single best anesthetic technique for a given procedure. The anesthetic should be aligned with the demands of the procedure and the skill sets of the providers. Patient safety always takes precedence, and the location should never be permitted to compromise care.