scholarly journals Identifying and Supporting Nonpharmacological Dementia Interventions Ready for Pragmatic Trials: Results From an Expert Workshop

2018 ◽  
Vol 19 (7) ◽  
pp. 560-562 ◽  
Author(s):  
Rosa R. Baier ◽  
Susan L. Mitchell ◽  
Eric Jutkowitz ◽  
Vincent Mor
Author(s):  
Claire L Chan ◽  
Monica Taljaard ◽  
Gillian A Lancaster ◽  
Jamie C Brehaut ◽  
Sandra M Eldridge

2014 ◽  
Vol 11 (3) ◽  
pp. 292-299 ◽  
Author(s):  
Charlene R Weir ◽  
Jorie Butler ◽  
Iona Thraen ◽  
Patricia A Woods ◽  
John Hermos ◽  
...  

2017 ◽  
Vol 17 (8) ◽  
pp. 1393-1409 ◽  
Author(s):  
Rob Lamb ◽  
Willy Aspinall ◽  
Henry Odbert ◽  
Thorsten Wagener

Abstract. Scour (localised erosion) during flood events is one of the most significant threats to bridges over rivers and estuaries, and has been the cause of numerous bridge failures, with damaging consequences. Mitigation of the risk of bridges being damaged by scour is therefore important to many infrastructure owners, and is supported by industry guidance. Even after mitigation, some residual risk remains, though its extent is difficult to quantify because of the uncertainties inherent in the prediction of scour and the assessment of the scour risk. This paper summarises findings from an international expert workshop on bridge scour risk assessment that explores uncertainties about the vulnerability of bridges to scour. Two specialised structured elicitation methods were applied to explore the factors that experts in the field consider important when assessing scour risk and to derive pooled expert judgements of bridge failure probabilities that are conditional on a range of assumed scenarios describing flood event severity, bridge and watercourse types and risk mitigation protocols. The experts' judgements broadly align with industry good practice, but indicate significant uncertainty about quantitative estimates of bridge failure probabilities, reflecting the difficulty in assessing the residual risk of failure. The data and findings presented here could provide a useful context for the development of generic scour fragility models and their associated uncertainties.


2007 ◽  
Vol 191 (S50) ◽  
pp. s78-s84 ◽  
Author(s):  
Richard Hodgson ◽  
Chris Bushe ◽  
Robert Hunter

BackgroundRandomised controlled trials (RCTs) are the gold standard for evaluating treatment efficacy. However, the outcomes of RCTs often lackclinical utility and usually do not address real-world effectivenessAimsTo review how traditional RCTs may be triangulatedwith other methodologies such as observational studies and pragmatic trials by highlighting recently reported studies, outcomes used and their respective meritsMethodLiterature review focusing on drug treatmentResultsRecently reported observational and some pragmatic studies show a degree of consistency in reported results and use outcomes that have face validity for cliniciansConclusionsNo single experimental paradigm or outcome provides the necessary data to optimise treatment of mental illness in the clinical setting


JAMA ◽  
2011 ◽  
Vol 306 (17) ◽  
pp. 1851-1852 ◽  
Author(s):  
M. Mitka
Keyword(s):  

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