Mechanism of autoimmune hepatic fibrogenesis induced by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6

2013 ◽  
Vol 44 ◽  
pp. 49-60 ◽  
Author(s):  
Edith Hintermann ◽  
Janine Ehser ◽  
Monika Bayer ◽  
Josef M. Pfeilschifter ◽  
Urs Christen
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Cytochrome P450 2D6 ◽  
Hepatic Fibrogenesis ◽  
P450 2D6

Selective Inhibition of Cytochrome P450 2D6 by Sarpogrelate and Its Active Metabolite, M-1, in Human Liver Microsomes

2013 ◽  
Vol 42 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Doo-Yeoun Cho ◽  
Soo Hyeon Bae ◽  
Joeng Kee Lee ◽  
Yang Weon Kim ◽  
Bom-Taeck Kim ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Active Metabolite ◽  
Human Liver ◽  
Liver Microsomes ◽  
Selective Inhibition ◽  
Human Liver Microsomes ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

scholarly journals Determinants of Cytochrome P450 2D6 mRNA Levels in Healthy Human Liver Tissue

2019 ◽  
Vol 12 (4) ◽  
pp. 416-423
Author(s):  
Miaoran Ning ◽  
Julio D. Duarte ◽  
Faith Stevison ◽  
Nina Isoherranen ◽  
Leah H. Rubin ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Liver Tissue ◽  
Human Liver ◽  
Mrna Levels ◽  
Cytochrome P450 2D6 ◽  
Healthy Human ◽  
Human Liver Tissue ◽  
P450 2D6

Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver

PROTEOMICS ◽  
2009 ◽  
Vol 9 (9) ◽  
pp. 2313-2323 ◽  
Author(s):  
Elmar Langenfeld ◽  
Ulrich M. Zanger ◽  
Klaus Jung ◽  
Helmut E. Meyer ◽  
Katrin Marcus
Keyword(s):  
Mass Spectrometry ◽  
Cytochrome P450 ◽  
Human Liver ◽  
Absolute Quantification ◽  
Cytochrome P450 2D6 ◽  
Microsomal Cytochrome ◽  
Microsomal Cytochrome P450 ◽  
P450 2D6

scholarly journals Human liver mitochondrial cytochrome P450 2D6 - individual variations and implications in drug metabolism

FEBS Journal ◽  
2009 ◽  
Vol 276 (13) ◽  
pp. 3440-3453 ◽  
Author(s):  
Michelle Cook Sangar ◽  
Hindupur K. Anandatheerthavarada ◽  
Weigang Tang ◽  
Subbuswamy K. Prabu ◽  
Martha V. Martin ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Human Liver ◽  
Mitochondrial Cytochrome ◽  
Cytochrome P450 2D6 ◽  
Individual Variations ◽  
P450 2D6

scholarly journals Alkamides from Piper nigrum L. and Their Inhibitory Activity against Human Liver Microsomal Cytochrome P450 2D6 (CYP2D6)

2006 ◽  
Vol 1 (1) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
Subehan ◽  
Tepy Usia ◽  
Shigetoshi Kadota ◽  
Yasuhiro Tezuka
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Chemical Constituents ◽  
Liver Microsomes ◽  
Piper Nigrum ◽  
Cytochrome P450 2D6 ◽  
Potent Inhibition ◽  
Microsomal Cytochrome P450 ◽  
P450 2D6 ◽  
Demethylation Activity

Drug–herb interaction through inhibition of cytochrome P450 alters the pharmacological response and/or toxicities of drug used concomitantly. In our screening, Piper nigrum L. was observed to inhibit cytochrome P450 2D6 (CYP2D6) in human liver microsomes. Thus, the MeOH extract of this plant was investigated for their chemical constituents and 19 alkamides including a new pipercyclobutanamide were isolated. Their structures were elucidated on the basis of spectroscopic analyses. The isolated compounds were tested for their inhibition on human liver microsomal dextromethorphan O-demethylation activity, a selective marker for CYP2D6, and pipercyclobutanamide A (17) showed the most potent inhibition with an IC50 value of 0.34 μM. The result demonstrated the potential of drug–alkamides interaction on concomitant consume of white pepper with the drugs being metabolized by CYP2D6.

Polymorphic cytochrome P450 2D6 as the responsible enzyme of activation

2018 ◽  
Author(s):  
Ingolf Cascorbi
Keyword(s):  
Clinical Trials ◽  
Cytochrome P450 ◽  
Human Liver ◽  
Drug Action ◽  
Moderate Pain ◽  
Cytochrome P450 2D6 ◽  
Narcotic Drug ◽  
Cytochrome P 450 ◽  
P450 2D6 ◽  
Important Milestone

The landmark paper discussed in this chapter is ‘Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)’, published by Dayer et al. in 1988. Codeine is an old but frequently prescribed drug used for the treatment of mild-to-moderate pain. However, its use is nowadays restricted after observations of partly fatal respiratory repression in children. Codeine itself exhibits no analgesic effect, but is partly activated by O-demethylation to morphine by cytochrome P450 2D6 (CYP2D6). The identification of the polymorphic CYP2D6 as the enzyme responsible for activation was achieved by Dayer et al. in 1998 and was an important milestone contributing to the widely observed inter-individual differences of drug action and side effects of codeine. Translating the pharmacogenetics of codeine into clinical practice is currently underway in clinical trials, to identify ineffective analgesics and, in particular, avoid severe adverse events.

Induction of hepatic fibrosis by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
E Hintermann ◽  
J Ehser ◽  
M Bayer ◽  
J Pfeilschifter ◽  
U Christen
Keyword(s):  
Cytochrome P450 ◽  
Hepatic Fibrosis ◽  
Human Liver ◽  
Cytochrome P450 2D6 ◽  
P450 2D6
Sign in / Sign up

Export Citation Format

Share Document