scholarly journals Human liver mitochondrial cytochrome P450 2D6 - individual variations and implications in drug metabolism

FEBS Journal ◽  
2009 ◽  
Vol 276 (13) ◽  
pp. 3440-3453 ◽  
Author(s):  
Michelle Cook Sangar ◽  
Hindupur K. Anandatheerthavarada ◽  
Weigang Tang ◽  
Subbuswamy K. Prabu ◽  
Martha V. Martin ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Human Liver ◽  
Mitochondrial Cytochrome ◽  
Cytochrome P450 2D6 ◽  
Individual Variations ◽  
P450 2D6

Selective Inhibition of Cytochrome P450 2D6 by Sarpogrelate and Its Active Metabolite, M-1, in Human Liver Microsomes

2013 ◽  
Vol 42 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Doo-Yeoun Cho ◽  
Soo Hyeon Bae ◽  
Joeng Kee Lee ◽  
Yang Weon Kim ◽  
Bom-Taeck Kim ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Active Metabolite ◽  
Human Liver ◽  
Liver Microsomes ◽  
Selective Inhibition ◽  
Human Liver Microsomes ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

scholarly journals Determinants of Cytochrome P450 2D6 mRNA Levels in Healthy Human Liver Tissue

2019 ◽  
Vol 12 (4) ◽  
pp. 416-423
Author(s):  
Miaoran Ning ◽  
Julio D. Duarte ◽  
Faith Stevison ◽  
Nina Isoherranen ◽  
Leah H. Rubin ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Liver Tissue ◽  
Human Liver ◽  
Mrna Levels ◽  
Cytochrome P450 2D6 ◽  
Healthy Human ◽  
Human Liver Tissue ◽  
P450 2D6

Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver

PROTEOMICS ◽  
2009 ◽  
Vol 9 (9) ◽  
pp. 2313-2323 ◽  
Author(s):  
Elmar Langenfeld ◽  
Ulrich M. Zanger ◽  
Klaus Jung ◽  
Helmut E. Meyer ◽  
Katrin Marcus
Keyword(s):  
Mass Spectrometry ◽  
Cytochrome P450 ◽  
Human Liver ◽  
Absolute Quantification ◽  
Cytochrome P450 2D6 ◽  
Microsomal Cytochrome ◽  
Microsomal Cytochrome P450 ◽  
P450 2D6

scholarly journals Alkamides from Piper nigrum L. and Their Inhibitory Activity against Human Liver Microsomal Cytochrome P450 2D6 (CYP2D6)

2006 ◽  
Vol 1 (1) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
Subehan ◽  
Tepy Usia ◽  
Shigetoshi Kadota ◽  
Yasuhiro Tezuka
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Chemical Constituents ◽  
Liver Microsomes ◽  
Piper Nigrum ◽  
Cytochrome P450 2D6 ◽  
Potent Inhibition ◽  
Microsomal Cytochrome P450 ◽  
P450 2D6 ◽  
Demethylation Activity

Drug–herb interaction through inhibition of cytochrome P450 alters the pharmacological response and/or toxicities of drug used concomitantly. In our screening, Piper nigrum L. was observed to inhibit cytochrome P450 2D6 (CYP2D6) in human liver microsomes. Thus, the MeOH extract of this plant was investigated for their chemical constituents and 19 alkamides including a new pipercyclobutanamide were isolated. Their structures were elucidated on the basis of spectroscopic analyses. The isolated compounds were tested for their inhibition on human liver microsomal dextromethorphan O-demethylation activity, a selective marker for CYP2D6, and pipercyclobutanamide A (17) showed the most potent inhibition with an IC50 value of 0.34 μM. The result demonstrated the potential of drug–alkamides interaction on concomitant consume of white pepper with the drugs being metabolized by CYP2D6.

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