scholarly journals Lung clearance index during hospital admission in school-age children with cystic fibrosis

2014 ◽  
Vol 13 (6) ◽  
pp. 687-691 ◽  
Author(s):  
Liam Welsh ◽  
Christopher Nesci ◽  
Haily Tran ◽  
Marisol Tomai ◽  
Sarath Ranganathan
Keyword(s):  
Cystic Fibrosis ◽  
Hospital Admission ◽  
School Age Children ◽  
School Age ◽  
Lung Clearance ◽  
Lung Clearance Index

scholarly journals Variability of lung clearance index in clinically stable cystic fibrosis lung disease in school age children

2018 ◽  
Vol 17 (2) ◽  
pp. 236-241 ◽  
Author(s):  
Marcus Svedberg ◽  
Per M. Gustafsson ◽  
Paul D. Robinson ◽  
Monica Rosberg ◽  
Anders Lindblad
Keyword(s):  
Cystic Fibrosis ◽  
Lung Disease ◽  
Cystic Fibrosis Lung ◽  
School Age Children ◽  
School Age ◽  
Lung Clearance ◽  
Cystic Fibrosis Lung Disease ◽  
Lung Clearance Index

Effect of late preterm birth on lung clearance index and respiratory physiology in school‐age children

2019 ◽  
Author(s):  
Karin Yaacoby‐Bianu ◽  
Moran T. Plonsky ◽  
Michal Gur ◽  
Ronen Bar‐Yoseph ◽  
Amir Kugelman ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Respiratory Physiology ◽  
Late Preterm ◽  
School Age Children ◽  
School Age ◽  
Lung Clearance ◽  
Late Preterm Birth ◽  
Lung Clearance Index

Determinants of lung disease progression measured by lung clearance index in children with cystic fibrosis

2021 ◽  
pp. 2003380
Author(s):  
Sanja Stanojevic ◽  
Stephanie D. Davis ◽  
Lucy Perrem ◽  
Michelle Shaw ◽  
George Retsch-Bogart ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Disease ◽  
Disease Progression ◽  
Forced Expiratory Volume ◽  
School Age ◽  
Lung Clearance ◽  
Time Period ◽  
Early School ◽  
Lung Clearance Index ◽  
Multiple Breath Washout

BackgroundThe lung clearance index (LCI) measured by the multiple breath washout (MBW) test is sensitive to early lung disease in children with cystic fibrosis (CF). While LCI worsens during the preschool years in CF, there is limited evidence to clarify whether this continues during the early school age years, and whether the trajectory of disease progression as measured by LCI is modifiable.MethodsA cohort of children (healthy (HC) and CF) previously studied for 12 months as preschoolers were followed during school age (5–10 years). LCI was measured every 3 months for a period of 24 months using the Exhalyzer® D MBW nitrogen washout device. Linear mixed effects regression was used to model changes in LCI over time.ResultsA total of 582 MBW measurements in 48 healthy subjects and 845 measurements in 64 CF subjects were available. The majority of children with CF had elevated LCI at the first preschool and first school age visits (57.8% (37/64)), whereas all but six had normal forced expiratory volume in 1 s (FEV1) values at the first school age visit. During school age years, the course of disease was stable (−0.02 units·year−1 (95% CI −0.14; 0.10). LCI measured during preschool years, as well as the rate of LCI change during this time period, were important determinants of LCI and FEV1, at school age.ConclusionPreschool LCI was a major determinant of school age LCI; these findings further support that the preschool years are critical for early intervention strategies.

Does the lung clearance index track from preschool to school age in children with cystic fibrosis?

2018 ◽  
Author(s):  
Michelle Klingel ◽  
Sarah Isaac ◽  
Sanja Stanojevic ◽  
Renee Jensen ◽  
Melinda Solomon ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
School Age ◽  
Lung Clearance ◽  
Lung Clearance Index

scholarly journals Lung Clearance Index in Children with Cystic Fibrosis during Pulmonary Exacerbation

2021 ◽  
Vol 10 (21) ◽  
pp. 4884
Author(s):  
Katarzyna Walicka-Serzysko ◽  
Magdalena Postek ◽  
Justyna Milczewska ◽  
Dorota Sands
Keyword(s):  
Cystic Fibrosis ◽  
Stable Condition ◽  
School Age Children ◽  
Pulmonary Exacerbation ◽  
Intravenous Antibiotic ◽  
Lung Clearance ◽  
Factors Affecting ◽  
Lung Clearance Index ◽  
Relative Change

(1) Background: Pulmonary exacerbation (PEx) is one of the main factors affecting the quality of life and life expectancy in patients with cystic fibrosis (CF). Our study aimed to evaluate the change in selected pulmonary function parameters, including lung clearance index (LCI), in patients with CF diagnosed with PEx. (2) Methods: We enrolled 40 children with CF aged 6–17. They performed spirometry and multiple breath nitrogen washout (MBNW) tests during a stable condition period at the beginning and the end of intravenous antibiotic treatment. (3) Results: LCI increased by 65% and FEV1 decreased by ≥10% in 40% of patients with CF during PEx. An absolute change in LCI between a stable condition period and PEx was 1.05 (±1.92) units, which corresponds to a relative change of 11.48% (±18.61) of the baseline. The relative decrease in FEV1 was −9.22% (±12.00) and the z-score was −0.67 (±1.13). After the PEx treatment, FEV1 increased by 11.05% (±9.04) on average, whereas LCI decreased by 1.21 ± 1.59 units on average, which represented 9.42% ± 11.40 compared to the value at the beginning of PEx. (4) Conclusions: The change in LCI captures a higher proportion of events with functional impairment than FEV1 in school-age children with CF.

scholarly journals Long-term course of lung clearance index between infancy and school-age in cystic fibrosis subjects

2011 ◽  
Vol 10 (6) ◽  
pp. 487-490 ◽  
Author(s):  
Elisabeth Kieninger ◽  
Florian Singer ◽  
Oliver Fuchs ◽  
Chiara Abbas ◽  
Urs Frey ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
School Age ◽  
Lung Clearance ◽  
Lung Clearance Index

Lung clearance index tracks from preschool to school age in children with cystic fibrosis

2019 ◽  
Author(s):  
Bettina Sarah Frauchiger ◽  
Severin Binggeli ◽  
Sophie Yammine ◽  
Philipp Latzin ◽  
Kathryn A. Ramsey
Keyword(s):  
Cystic Fibrosis ◽  
School Age ◽  
Lung Clearance ◽  
Lung Clearance Index
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