Long-term effect of neonatal antagonism of ionotropic glutamate receptors on dendritic spines and cognitive function in rats

PurposeThis study aimed to examine the long-term association between social activity, physical function decline and cognitive function, as well as verify the long-term mediating effect of physical function decline on the relationship between social activity and cognitive function.MethodsData from the Korean Longitudinal Study of Aging (KLoSA) that was collected over 10 years was analyzed. The sample included 10,240 adults aged 45–93 years (Mean age = 61.66 [SD = 11.061]). Multivariate latent growth modeling (LGM) was applied to verify the long-term effect of social activity and physical function on cognitive function.ResultsThe results revealed that social activity had a positive impact on cognitive function and negative impact on physical function decline after controlling for age and education level. Additionally, physical function decline negatively influenced cognitive function. Finally, social activity indirectly affected cognitive function through physical function decline.ConclusionThe contribution of this study was to test the long-term effect social activity on physical and cognitive function.

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Long-Term Effect of Diabetes and Its Treatment on Cognitive Function

New England Journal of Medicine ◽

10.1056/nejmx090057 ◽

2009 ◽

Vol 361 (19) ◽

pp. 1914-1914 ◽

Cited By ~ 1

Keyword(s):

Cognitive Function ◽

Term Effect ◽

Long Term Effect

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Effect of Synaid on cognitive functions and mood in elderly subjects with self-perceived loss of memory after COVID-19 infection

Archives of Medical Science ◽

10.5114/aoms/141502 ◽

2021 ◽

Vol 17 (6) ◽

pp. 1797-1799

Author(s):

Marilisa Bove ◽

Federica Fogacci ◽

Silvia Quattrocchi ◽

Maddalena Veronesi ◽

Arrigo Cicero

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Function ◽

Elderly Patients ◽

Cognitive Functions ◽

Term Effect ◽

Elderly Subjects ◽

Long Term Effect ◽

At Home

IntroductionThere is growing attention towards the possible long-term effect of COVID-19 on neuropsychiatric disorders.Material and methodsWe tested the effect of a combined nutraceutical (Synaid) with known nootropic effects in 40 elderly patients with self-perceived cognitive decline after SARS-CoV-2 infection, treated at home or in hospital.ResultsAfter 3 months of treatment, Synaid significantly improved functional status, MMSE and the main psychological disorders associated with mild cognitive impairment, both in patients previously cared for at home and in hospital because of SARS-CoV-2 infection.ConclusionsSynaid was well tolerated and effective in improving cognitive function and psychosocial parameters after SARS-CoV-2 infection.

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