scholarly journals Effect of Synaid on cognitive functions and mood in elderly subjects with self-perceived loss of memory after COVID-19 infection

2021 ◽  
Vol 17 (6) ◽  
pp. 1797-1799
Author(s):  
Marilisa Bove ◽  
Federica Fogacci ◽  
Silvia Quattrocchi ◽  
Maddalena Veronesi ◽  
Arrigo Cicero
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Elderly Patients ◽  
Cognitive Functions ◽  
Term Effect ◽  
Elderly Subjects ◽  
Long Term Effect ◽  
At Home

IntroductionThere is growing attention towards the possible long-term effect of COVID-19 on neuropsychiatric disorders.Material and methodsWe tested the effect of a combined nutraceutical (Synaid) with known nootropic effects in 40 elderly patients with self-perceived cognitive decline after SARS-CoV-2 infection, treated at home or in hospital.ResultsAfter 3 months of treatment, Synaid significantly improved functional status, MMSE and the main psychological disorders associated with mild cognitive impairment, both in patients previously cared for at home and in hospital because of SARS-CoV-2 infection.ConclusionsSynaid was well tolerated and effective in improving cognitive function and psychosocial parameters after SARS-CoV-2 infection.

scholarly journals Social Cognition in Rehabilitation Context: Different Evolution of Affective and Cognitive Theory of Mind in Mild Cognitive Impairment

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Federica Rossetto ◽  
Francesca Baglio ◽  
Davide Massaro ◽  
Margherita Alberoni ◽  
Raffaello Nemni ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Social Skills ◽  
Mild Cognitive Impairment ◽  
Theory Of Mind ◽  
Cognitive Theory ◽  
Term Effect ◽  
Home Based ◽  
Long Term Effect ◽  
High Level

Maintaining social skills such as Theory of Mind (ToM) competences is important to counteract the conversion into dementia in Mild Cognitive Impairment (MCI). Multidimensional nonpharmacological interventions demonstrated their potential in improving cognitive and behavioral abilities; however, little is known about the long-term effect of such interventions on social skills in people with MCI. The aim of this longitudinal study was to monitor ToM competences considering both cognitive and affective domains in an amnestic MCI (aMCI) sample involved in a home-based multistimulation treatment (MST@H). 30 aMCI subjects (M:F=15:15; mean age±SD=77.00±4.60) were enrolled, and three steps of evaluation with neuropsychological tests and ToM tasks have been implemented. 21 healthy controls (HC) were also included (M:F=9:12; mean age±SD=74.95±3.88) to characterize the aMCI sample regarding differences in ToM performance compared to HC at the baseline evaluation. Our results show that the aMCI group statistically significantly underperformed the HC group only in the advanced ToM tasks, confirming an initial decline of high-level ToM competences in this population. The longitudinal evaluation revealed time changes not only in some subcognitive domains of MoCA (memory and executive functions) but also in cognitive and affective ToM dimensions in aMCI subjects. Our findings suggest that cognitive and affective ToM can be considered useful outcome measures to test the long-term effect of treatment over time.

Short and long term effect of cognitive rehabilitation in mild cognitive impairment subtypes in Parkinson's disease

2016 ◽  
Vol 22 ◽  
pp. e74
Author(s):  
Maria Diez-Cirarda ◽  
Natalia Ojeda ◽  
Javier Peña ◽  
Olaia Lucas-Jimenez ◽  
María Ángeles Gómez-Beldarrain ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Rehabilitation ◽  
Term Effect ◽  
Long Term Effect ◽  
Short And Long Term

2306-PUB: Long-Term Effect of Liraglutide on the Prevention of Progression of Diabetic Nephropathy in Elderly Patients with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2306-PUB
Author(s):  
MAMI YOSHIDA ◽  
AI YOSHIDA ◽  
ERIKO OH ◽  
NAOMUNE YAMAMOTO ◽  
EUN SASAKI ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Elderly Patients ◽  
Term Effect ◽  
Long Term Effect

scholarly journals Intermittent Fasting Enhanced the Cognitive Function in Older Adults with Mild Cognitive Impairment by Inducing Biochemical and Metabolic changes: A 3-Year Progressive Study

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2644 ◽  
Author(s):  
Theng Choon Ooi ◽  
Asheila Meramat ◽  
Nor Fadilah Rajab ◽  
Suzana Shahar ◽  
Intan Safinar Ismail ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Successful Aging ◽  
Ketone Bodies ◽  
Fasting Blood Glucose ◽  
Elderly Subjects ◽  
Intermittent Fasting

Intermittent fasting (IF) refers to various dietary regimens that cycle between a period of non-fasting and a period of total fasting. This study aimed to determine the effects of IF on cognitive function among elderly individuals who practice IF who have mild cognitive impairment (MCI). A total of 99 elderly subjects with MCI of Malay ethnicity without any terminal illness were recruited from a larger cohort study, LRGS TUA. The subjects were divided into three groups, comprising those who were regularly practicing IF (r-IF), irregularly practicing IF (i-IF), and non-fasters (n-IF). Upon 36 months of follow-up, more MCI subjects in the r-IF group reverted to successful aging with no cognitive impairment and diseases (24.3%) compared to those in i-IF (14.2%) and n-IF groups (3.7%). The r-IF group’s subjects exhibited significant increment in superoxide dismutase (SOD) activity and reduction in body weight, levels of insulin, fasting blood glucose, malondialdehyde (MDA), C-reactive protein (CRP), and DNA damage. Moreover, metabolomics analysis showed that IF may modulate cognitive function via various metabolite pathways, including the synthesis and degradation of ketone bodies, butanoate metabolism, pyruvate metabolism, and glycolysis and gluconeogenesis pathways. Overall, the MCI-afflicted older adults who practiced IF regularly had better cognitive scores and reverted to better cognitive function at 36 months follow-up.

scholarly journals Safety and Long-Term Effect Assessment of Neoadjuvant Chemoradiotherapy for Elderly Patients With Locally Advanced Rectal Cancer: A CHN Single-Center Retrospective Study

2020 ◽  
Vol 19 ◽  
pp. 153303382097033
Author(s):  
Hengchang Liu ◽  
Chunxiang Li ◽  
Zhixun Zhao ◽  
Xu Guan ◽  
Ming Yang ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Locally Advanced ◽  
Neoadjuvant Chemoradiotherapy ◽  
Advanced Rectal Cancer ◽  
The Elderly ◽  
Locally Advanced Rectal Cancer ◽  
Term Effect ◽  
Elderly Group ◽  
Long Term Effect

Introduction: Neoadjuvant chemoradiotherapy (nCRT) followed by operation has become the standard treatment for locally advanced rectal cancer (LARC). However, considering the possible toxicity and complications of radiochemotherapy, nCRT is seldom used for the elderly. The purpose of this study was to assess the safety and long-term effect of nCRT combined with TME in elderly patients with LARC. Method: Four-hundred-fourteen LARC patients were divided into 2 groups: 108 patients were in the elderly group (≥ 65 years old) and 306 patients were in the non-elderly group (<65 years old). The side effects, toxicity, complications, disease-free survival (DFS), and overall survival (OS) of all of the patients were assessed. Results: The data comprised 103 patients in the elderly group and 292 patients in the non-elderly group who completed nCRT sessions following operation. The treatment-completion rates of the elderly and non-elderly groups were 95.37% and 95.42%, respectively. Twenty-two patients developed radiotherapy complications (grade III) in the elderly group and 37 such cases developed in the non-elderly group. Diarrhea, skinulcer, and perianal pain were ranked as the top 3 most common complications. The incidence of infection, anastomotic leakage, and intestinal obstruction was 0.97% in the elderly group. The 5-year DFS and 5-year OS rate were 70.7% and 80.8% in the elderly group, 67.3% and 81.6% in the non-elderly group respectively. Conclusions: nCRT are safe and effective for elderly patients, and it does not increase the risk of postoperative complications for the elderly. Hence, nCRT should not be withheld based on age alone.

Behavior Therapy and Withdrawal of Stimulant Medication in Hyperactive Children

PEDIATRICS ◽  
1978 ◽  
Vol 61 (2) ◽  
pp. 211-217
Author(s):  
Susan G. O'Leary ◽  
William E. Pelham
Keyword(s):  
Stimulant Medication ◽  
Term Effect ◽  
School Settings ◽  
Long Term Effect ◽  
Hyperactive Children ◽  
Stimulant Medications ◽  
Psychopharmacological Intervention ◽  
Psychostimulant Medication ◽  
At Home

Psychopharmacological intervention has been the most frequent treatment for hyperactive children for two decades. Recent estimates suggest that approximately 2% of all U.S. elementary schoolchildren are receiving psychostimulant medication for hyperactivity.1 Dextroamphetamine sulfate (Dexedrine) and methylphenidate (Ritalin) hydrochloride are the most frequently administered psychostimulant medications. The efficacy of these drugs in changing teacher ratings of hyperactivity and improving sustained attention has been well established.2 Despite the consistency of salutary effects of stimulants on hyperactive children in school settings, the exclusive reliance on drug treatment has been questioned repeatedly.3-5 The concern stems from several sources. First, such treatment appears to have no long-term effect on academic achievement.6,7 Second, such treatment does not appear to be associated with long-term amelioration of social problems.7 Third, increases in heart rate and blood pressure have been observed,8 and decreases in the rate of height and weight gains have been found in some studies.4 Although the decrease in weight gain in probably reversible, the same may not be true of the decrease in height gains. Fourth, the child's attribution of his behavior change to the medication may have deleterious long-range effects. The child may learn that the only way to control his behavior is to take a pill.9 Fifth, because of the anorexic and insomnious effects of the stimulant medications, they are usually not administered in the late afternoon. Since the effects of the medication last only three to five hours, change in the children's behavior at home is often not observed.10 Thus, the parents whose children are given medication without psychological consultation are often faced with serious problems at home.

scholarly journals Long-term effect of Helicobacter pylori eradication on plasma homocysteine in elderly patients with cobalamin deficiency

Gut ◽  
2007 ◽  
Vol 56 (4) ◽  
pp. 469-474 ◽  
Author(s):  
M. C. A. Marino ◽  
C. A. de Oliveira ◽  
A. M. C. Rocha ◽  
G. A. Rocha ◽  
N. C. D. Clementino ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Elderly Patients ◽  
Plasma Homocysteine ◽  
Term Effect ◽  
Cobalamin Deficiency ◽  
Helicobacter Pylori Eradication ◽  
Long Term Effect
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