Rapid and sensitive HPLC assay for simultaneous determination of procaine and para-aminobenzoic acid from human and rat liver tissue extracts

2008 ◽  
Vol 867 (2) ◽  
pp. 247-252 ◽  
Author(s):  
Mugunthu R. Dhananjeyan ◽  
Jill A. Trendel ◽  
Crystal Bykowski ◽  
Jeffrey G. Sarver ◽  
Howard Ando ◽  
...  
2007 ◽  
Vol 847 (2) ◽  
pp. 224-230 ◽  
Author(s):  
Mugunthu R. Dhananjeyan ◽  
Crystal Bykowski ◽  
Jill A. Trendel ◽  
Jeffrey G. Sarver ◽  
Howard Ando ◽  
...  

2008 ◽  
Vol 46 (1) ◽  
pp. 23-29 ◽  
Author(s):  
K. Marika ◽  
F. Katherine ◽  
L. Jianmin ◽  
C. G. Mike ◽  
F. Debra

1998 ◽  
Vol 81 (3) ◽  
pp. 519-527 ◽  
Author(s):  
Jean-michel Delmas ◽  
Anne-marie Chape ◽  
Pascal Sanders

abstract A simple, sensitive, and rapid method for simultaneous determination of residues of flumequine and its microbiologically active metabolite 7-hydroxyflumequine in 100 mg sheep edible tissues (muscle, liver, kidney, and fat) by liquid chromatography is reported. After liquid-liquid cleanup with ethyl acetate, tissue extracts were injected onto a Select B column. The 2 compounds were determined by ultraviolet and fluorimetric detection. The method was repeatable and reproducible for flumequine and 7-hydroxyflumequine in muscle, liver, kidney, and fat, with limits of detection below 2 and 3 μg/kg for flumequine and 7-hydroxyflumequine, respectively. Mean recoveries for flumequine were 90 ± 7, 82 ± 7,89 ± 5, and 82 ± 6% in muscle, liver, kidney, and fat, respectively. Mean recoveries for 7-hydroxyflumequine were 91 ± 2, 90 ± 4, 86 ± 3, and 84 ± 4% in muscle, liver, kidney, and fat, respectively.


2004 ◽  
Vol 23 (4) ◽  
pp. 390-393 ◽  
Author(s):  
Julie Sunderland ◽  
Andrew M Lovering ◽  
Caroline M Tobin ◽  
Alasdair P MacGowan ◽  
John M Roe ◽  
...  

Bioanalysis ◽  
2014 ◽  
Vol 6 (22) ◽  
pp. 3025-3038 ◽  
Author(s):  
Paulo Magalhães ◽  
Gilberto Alves ◽  
Márcio Rodrigues ◽  
Adrián LLerena ◽  
Amílcar Falcão

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