scholarly journals Carbon monoxide analysis method in human blood by Airtight Gas Syringe – Gas Chromatography – Mass Spectrometry (AGS-GC-MS): Relevance for postmortem poisoning diagnosis

2018 ◽  
Vol 1090 ◽  
pp. 81-89 ◽  
Author(s):  
S. Oliverio ◽  
V. Varlet
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Carbon Monoxide ◽  
Human Blood ◽  
Gas Chromatography Mass Spectrometry ◽  
Analysis Method ◽  
Chromatography Mass Spectrometry

scholarly journals Quantification of Morpholine in Peel and Pulp of Apples and Oranges by Gas Chromatography−Mass Spectrometry

Foods ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 746
Author(s):  
Kunho An ◽  
Inhwan Kim ◽  
Chan Lee ◽  
Joon-Kwan Moon ◽  
Hee-Jae Suh ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Fruits And Vegetables ◽  
Citrus Fruit ◽  
The United States ◽  
Gas Chromatography Mass Spectrometry ◽  
Citrus Fruits ◽  
Analysis Method ◽  
Method Detection Limit ◽  
Chromatography Mass Spectrometry

Morpholine salts of fatty acids have been used in wax coatings on the surfaces of fruit and vegetable commodities in China and the United States, etc. However, morpholine usage was prohibited in many other countries because of safety concerns. We optimized analytical methods to determine morpholine in the peel and pulp of fruits and vegetables by gas chromatography-mass spectrometry (GC-MS). This morpholine analysis method was applied to real samples of apples, citrus fruits, and vegetables from Korea, China, and the U.S. The method was validated using apple and citrus fruit peels and pulp. The method detection limit (MDL) was 1.3–3.3 µg/kg. The recovery rates of morpholine were 88.6–107.2% over a fortified level of 10–400 µg/kg. Intra-day and inter-day precisions were 1.4–9.4% and 1.5–2.8%, respectively. The morpholine concentrations were n.d. (not detected)–11.19 and n.d. (not detected)–12.82 µg/kg in apple and citrus peels, respectively. Morpholine was not detected in citrus or apple pulp samples or in vegetable samples.

scholarly journals Simultaneous Quantification of the New Psychoactive Substances 3-FMC, 3-FPM, 4-CEC, and 4-BMC in Human Blood using GC-MS

2019 ◽  
Vol 17 (1) ◽  
pp. 902-911
Author(s):  
Abdulsallam Bakdash
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Human Blood ◽  
Solid Phase ◽  
Internal Standard ◽  
Gas Chromatography Mass Spectrometry ◽  
New Psychoactive Substances ◽  
Selected Ion Monitoring ◽  
Simultaneous Quantification ◽  
Chromatography Mass Spectrometry

AbstractA gas chromatography-mass spectrometry (GC-MS) method for simultaneous quantification of 3-fluoromethcathinone (3-FMC), (±)-3-fluorophenmetrazine (3-FPM), 4-chloroethcathinone (4-CEC) and 4-Bromomethcathinone (4-BMC) in human blood with (±)-methcathinone-D3 as internal standard has been developed and validated. Whole blood samples were treated with 10% trichloroacetic acid for protein precipitation before solid phase extraction. The method was selective, the calibration curves showed linearity for all substances with R2 ranging from 0.991 to 0.998 in the range 5-1.000 ng/mL. Analysis of blank samples showed no-sign of carryover. Precision and accuracy were acceptable with values less than 20% (RSD) and ± 20% (Bias). The limit of quantification (LOQ) for all substances was 5ng/mL. Intra-day and inter-day precision were 2.111.7% and 1.3 -10.2% respectively and accuracy biases were between -10.6-19.6% % (intra-day) and 11-12.1% (inter-day). The extraction efficiencies were 85.4, 82.8, 79.1 and 74.9% for 3-FMC, 3-FPM, 4-CEC and 4-BMC respectively.A robust and reliable simultaneous quantification method using gas chromatography-mass spectrometry in selected ion monitoring mode (GC-MS-SIM) is reported.

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