In vitro effects of estrogen and progesterone containing drugs on human erythrocyte carbonic anhydrase I and II isozymes in women smokers and nonsmokers

2015 ◽  
Vol 78 (9) ◽  
pp. 513-519 ◽  
Author(s):  
Mine Islimye Taskin ◽  
Cigdem Bilen ◽  
Adem Ergun ◽  
Nahit Gencer ◽  
Umit Inceboz
Keyword(s):  
Carbonic Anhydrase ◽  
Human Erythrocyte ◽  
Women Smokers ◽  
Carbonic Anhydrase I ◽  
In Vitro Effects ◽  
Erythrocyte Carbonic Anhydrase

scholarly journals Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Hilal Kuday ◽  
Fatih Sonmez ◽  
Cigdem Bilen ◽  
Emre Yavuz ◽  
Nahit Gençer ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Inhibitory Activity ◽  
Pyrimidine Derivatives ◽  
Structure Activity ◽  
Carbonic Anhydrase I ◽  
Activity Structure ◽  
In Vitro Inhibition ◽  
Inhibitory Activities ◽  
Erythrocyte Carbonic Anhydrase

In vitro inhibition effects of indolylchalcones and new pyrido[2,3-d]pyrimidine derivatives on purified human carbonic anhydrase I and II (hCA I and II) were investigated by using CO2as a substrate. The results showed that all compounds inhibited the hCA I and hCA II enzyme activities. Among all the synthesized compounds,7e(IC50=6.79 µM) was found to be the most active compound for hCA I inhibitory activity and5g(IC50=7.22 µM) showed the highest hCA II inhibitory activity. Structure-activity relationships study showed that indolylchalcone derivatives have higher inhibitory activities than pyrido[2,3-d]pyrimidine derivatives on hCA I and hCA II. Additionally, methyl group bonded to uracil ring increases inhibitory activities on both hCA I and hCA II.

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