Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy

2008 ◽  
Vol 127 (3) ◽  
pp. 208-218 ◽  
Author(s):  
Kyung Hyun Min ◽  
Kyeongsoon Park ◽  
Yoo-Shin Kim ◽  
Sang Mun Bae ◽  
Seulki Lee ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting ◽  
Drug Stability ◽  
Chitosan Nanoparticles ◽  
Glycol Chitosan ◽  
Hydrophobically Modified

Hydrophobically modified glycol chitosan nanoparticles as carriers for paclitaxel

2006 ◽  
Vol 111 (1-2) ◽  
pp. 228-234 ◽  
Author(s):  
Jong-Ho Kim ◽  
Yoo-Shin Kim ◽  
Sungwon Kim ◽  
Jae Hyung Park ◽  
Kwangmeyung Kim ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Glycol Chitosan ◽  
Hydrophobically Modified

Real-time and non-invasive optical imaging of tumor-targeting glycol chitosan nanoparticles in various tumor models

Biomaterials ◽  
2011 ◽  
Vol 32 (22) ◽  
pp. 5252-5261 ◽  
Author(s):  
Jin Hee Na ◽  
Heebeom Koo ◽  
Sangmin Lee ◽  
Kyung Hyun Min ◽  
Kyeongsoon Park ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Real Time ◽  
Tumor Targeting ◽  
Chitosan Nanoparticles ◽  
Tumor Models ◽  
Glycol Chitosan ◽  
Non Invasive

Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles

2007 ◽  
Vol 122 (3) ◽  
pp. 305-314 ◽  
Author(s):  
Kyeongsoon Park ◽  
Jong-Ho Kim ◽  
Yun Sik Nam ◽  
Seulki Lee ◽  
Hae Yun Nam ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Tumor Targeting ◽  
Chitosan Nanoparticles ◽  
Polymer Molecular Weight ◽  
Glycol Chitosan ◽  
Self Assembled

Tumor‐Targeting Glycol Chitosan Nanoparticles for Cancer Heterogeneity

2020 ◽  
Vol 32 (51) ◽  
pp. 2002197
Author(s):  
Ju Hee Ryu ◽  
Hong Yeol Yoon ◽  
In‐Cheol Sun ◽  
Ick Chan Kwon ◽  
Kwangmeyung Kim
Keyword(s):  
Tumor Targeting ◽  
Chitosan Nanoparticles ◽  
Glycol Chitosan ◽  
Cancer Heterogeneity

Self-assembled glycol chitosan nanoparticles for the sustained and prolonged delivery of antiangiogenic small peptide drugs in cancer therapy

Biomaterials ◽  
2008 ◽  
Vol 29 (12) ◽  
pp. 1920-1930 ◽  
Author(s):  
Jong-Ho Kim ◽  
Yoo-Shin Kim ◽  
Kyeongsoon Park ◽  
Eunah Kang ◽  
Seulki Lee ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Chitosan Nanoparticles ◽  
Peptide Drugs ◽  
Small Peptide ◽  
Glycol Chitosan ◽  
Self Assembled

Effect of the stability and deformability of self-assembled glycol chitosan nanoparticles on tumor-targeting efficiency

2012 ◽  
Vol 163 (1) ◽  
pp. 2-9 ◽  
Author(s):  
Jin Hee Na ◽  
Seung-Young Lee ◽  
Sangmin Lee ◽  
Heebeom Koo ◽  
Kyung Hyun Min ◽  
...  
Keyword(s):  
Tumor Targeting ◽  
Chitosan Nanoparticles ◽  
Glycol Chitosan ◽  
Targeting Efficiency ◽  
Self Assembled ◽  
The Stability

scholarly journals Folate-conjugated hydrophobicity modified glycol chitosan nanoparticles for targeted delivery of methotrexate in rheumatoid arthritis

2020 ◽  
Vol 18 ◽  
pp. 228080002096262 ◽  
Author(s):  
Zhongqing Wu ◽  
Kanna Xu ◽  
Jikang Min ◽  
Minchang Chen ◽  
Liping Shen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Targeted Delivery ◽  
Chitosan Nanoparticles ◽  
Autoimmune Disorder ◽  
Glycol Chitosan ◽  
Hydrophobically Modified ◽  
Superior Efficacy ◽  
Transmission Electron

Background: Targeted delivery to the Rheumatoid arthritis (RA) which is characterized by destruction and degeneration of bones due to chronic inflammation is of great need. RA being a chronic autoimmune disorder might result in severe disability and morbidity. A targeted delivery system is designed to deliver methotrexate (MTX) for RA. Methods: Here, we synthesized folic acid (FA) conjugated hydrophobically modified glycol chitosan (GC) self-assembled nanoparticles (FA-GC-SA) for the targeted delivery of MTX to RA. The FA conjugation and hydrophobic modification of GC by stearic acid (SA) was confirmed by Fourier-transform infrared spectroscopy (FTIR). The FA-GC-SA was exploited for developing targeted nanoparticles encapsulating MTX by the ionic gelation method. The particles were characterized and evaluated for their targeting potential in in vitro cell culture studies. Further their in vivo efficacy in arthritis induced rats using collagen was also evaluated. Results: FTIR confirms the successful modification of GC-SA and FA-GC-SA. The FA-GC-SA-MTX of size 153 ± 9 nm were prepared with high encapsulation efficiency of MTX. The FA-GC-SA-MTX size was further confirmed by transmission electron microscopy (TEM). In vitro cell studies revealed the superior efficacy of FA-GC-SA-MTX in cell cytotoxicity. Also, significantly higher cellular uptake of FA functionalized FA-GC-SA-MTX was observed in comparison to non-functionalized GC-SA-MTX attributed to folate receptors (FRs) mediated endocytosis. In vivo results confirms the potential of FA-GC-SA-MTX which reduces reduces the pro-inflammatory cytokines, paw thickness, and arthritis score in collagen induced rats. Conclusion: The results shows that FRs targeted FA-GC-SA-MTX has superior efficacy in the treatment of RA.

Hydrophobically modified PEGylated glycol chitosan nanoparticles: Synthesis, characterisation and anticancer property

2021 ◽  
Author(s):  
Wai Mun Chong ◽  
VUANGHAO LIM ◽  
Erazuliana Abd Kadir
Keyword(s):  
Aqueous Solution ◽  
Chitosan Nanoparticles ◽  
Glycol Chitosan ◽  
Hydrophobically Modified ◽  
Nanoparticles Synthesis

A novel palmitoylated glycol chitosan polymer grafted with PEG (PGC-PEG) was successfully developed to form amphiphilic micelles in aqueous solution. The incorporation of hydrophobic itraconazole (ITZ) with PGC-PEG polymer produced...

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