Self-assembled, dual drug carrying polymer-drug conjugate for co-delivery

2015 ◽  
Vol 213 ◽  
pp. e139-e140 ◽  
Author(s):  
Yan Li ◽  
Donglu Shi ◽  
Yongyong Li
Keyword(s):  
Drug Conjugate ◽  
Self Assembled ◽  
Dual Drug

Dual Drug Conjugate Loaded Nanoparticles for the Treatment of Cancer

2015 ◽  
Vol 12 (6) ◽  
pp. 782-794 ◽  
Author(s):  
Megha Matlapudi ◽  
Afrasim Moin ◽  
Raghavender Medishetti ◽  
K. Rajendra ◽  
Ashok Raichur ◽  
...  
Keyword(s):  
Drug Conjugate ◽  
Dual Drug

Self-assembled dual-drug loaded core-shell nanoparticles based on metal-free fully alternating polyester for cancer theranostics

2019 ◽  
Vol 101 ◽  
pp. 448-463 ◽  
Author(s):  
Piyush Kumar Gupta ◽  
Sreenath Pappuru ◽  
Santosh Gupta ◽  
Bamadeb Patra ◽  
Debashis Chakraborty ◽  
...  
Keyword(s):  
Core Shell ◽  
Shell Nanoparticles ◽  
Metal Free ◽  
Self Assembled ◽  
Cancer Theranostics ◽  
Core Shell Nanoparticles ◽  
Dual Drug

scholarly journals Implication of linker length on cell cytotoxicity, pharmacokinetic and toxicity profile of gemcitabine-docetaxel combinatorial dual drug conjugate

2018 ◽  
Vol 548 (1) ◽  
pp. 357-374 ◽  
Author(s):  
Varun Kushwah ◽  
Sameer S. Katiyar ◽  
Ashish Kumar Agrawal ◽  
Isha Saraf ◽  
Inder Pal Singh ◽  
...  
Keyword(s):  
Cell Cytotoxicity ◽  
Toxicity Profile ◽  
Drug Conjugate ◽  
Linker Length ◽  
Dual Drug

Preclinical Antitumor Activity of a Novel Folate-Targeted Dual Drug Conjugate

2007 ◽  
Vol 4 (5) ◽  
pp. 659-667 ◽  
Author(s):  
Christopher P. Leamon ◽  
Joseph A. Reddy ◽  
Iontcho R. Vlahov ◽  
Elaine Westrick ◽  
Alicia Dawson ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Drug Conjugate ◽  
Dual Drug

Integration of phospholipid-hyaluronic acid-methotrexate nanocarrier assembly and amphiphilic drug–drug conjugate for synergistic targeted delivery and combinational tumor therapy

2018 ◽  
Vol 6 (7) ◽  
pp. 1818-1833 ◽  
Author(s):  
Yang Li ◽  
Huabing Zhang ◽  
Yilin Chen ◽  
Jinyuan Ma ◽  
Jinyan Lin ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Delivery System ◽  
Targeted Delivery ◽  
Tumor Therapy ◽  
Drug Conjugate ◽  
Amphiphilic Drug ◽  
Polymeric Delivery ◽  
Dual Drug

A novel synergistic-targeting polymeric delivery system was developed to carry drug–drug conjugate for boosting dual-drug co-delivery and combinational tumor therapy.

Self-assembled thermosensitive nanoparticles based on oligoethylene glycol dendron conjugated doxorubicin: preparation, and efficient delivery of free doxorubicin

RSC Advances ◽  
2016 ◽  
Vol 6 (4) ◽  
pp. 2602-2610 ◽  
Author(s):  
Yanna Zhao ◽  
Jing Zhao ◽  
Chunying Hao ◽  
Meihua Han ◽  
Mincan Wang ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Conjugate ◽  
Efficient Delivery ◽  
Free Doxorubicin ◽  
Self Assembled ◽  
Oligoethylene Glycol

An amphiphilic dendron–drug conjugate was synthesized via oligoethylene glycol (OEG) dendrons coupled with anticancer drug doxorubicin (DOX).

Three-in-One Self-Assembled Nanocarrier for Dual-Drug Delivery, Two-Photon Imaging, and Chemo-Photodynamic Synergistic Therapy

2018 ◽  
Vol 10 (34) ◽  
pp. 28301-28313 ◽  
Author(s):  
Gang-Gang Yang ◽  
Liang Hao ◽  
Qian Cao ◽  
Hang Zhang ◽  
Jing Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Two Photon ◽  
Photon Imaging ◽  
Self Assembled ◽  
Two Photon Imaging ◽  
Dual Drug

scholarly journals Self-Assembled Nanomicelles of Affibody-Drug Conjugate with Excellent Therapeutic Property to Cure Ovary and Breast Cancers

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Xuelin Xia ◽  
Xiaoyuan Yang ◽  
Wei Huang ◽  
Xiaoxia Xia ◽  
Deyue Yan
Keyword(s):  
Cancer Therapy ◽  
Self Assembly ◽  
Targeted Delivery ◽  
Growth Factor Receptor ◽  
Circulation Time ◽  
Breast Cancers ◽  
Her2 Positive ◽  
Drug Conjugate ◽  
Self Assembled

AbstractAffibody molecules are small non-immunoglobulin affinity proteins, which can precisely target to some cancer cells with specific overexpressed molecular signatures. However, the relatively short in vivo half-life of them seriously limited their application in drug targeted delivery for cancer therapy. Here an amphiphilic affibody-drug conjugate is self-assembled into nanomicelles to prolong circulation time for targeted cancer therapy. As an example of the concept, the nanoagent was prepared through molecular self-assembly of the amphiphilic conjugate of ZHER2:342-Cys with auristatin E derivate, where the affibody used is capable of binding to the human epidermal growth factor receptor 2 (HER2). Such a nanodrug not only increased the blood circulation time, but also enhanced the tumor targeting capacity (abundant affibody arms on the nanoagent surface) and the drug accumulation in tumor. As a result, this affibody-based nanoagent showed excellent antitumor activity in vivo to HER2-positive ovary and breast tumor models, which nearly eradicated both small solid tumors (about 100 mm3) and large established tumors (exceed 500  mm3). The relative tumor proliferation inhibition ratio reaches 99.8% for both models.

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