Supercritical CO2 assisted preparation of chitosan-based nano-in-microparticles with potential for efficient pulmonary drug delivery

2021 ◽  
Vol 46 ◽  
pp. 101486
Author(s):  
Hu-Hong Peng ◽  
Zi-Dan Wang ◽  
Yi-Xin Guan ◽  
Shan-Jing Yao
2015 ◽  
Vol 101 ◽  
pp. 117-123 ◽  
Author(s):  
Ai-Zheng Chen ◽  
Na Tang ◽  
Shi-Bin Wang ◽  
Yong-Qiang Kang ◽  
Hu-Fan Song

Author(s):  
Kamal Dua ◽  
Mary Bebawy ◽  
Rajendra Awasthi ◽  
Rakesh K. Tekade ◽  
Muktika Tekade ◽  
...  

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1482
Author(s):  
Olga Cañadas ◽  
Andrea García-García ◽  
M. Auxiliadora Prieto ◽  
Jesús Pérez-Gil

Polyhydroxyalkanoates (PHA) are polyesters produced intracellularly by many bacterial species as energy storage materials, which are used in biomedical applications, including drug delivery systems, due to their biocompatibility and biodegradability. In this study, we evaluated the potential application of this nanomaterial as a basis of inhaled drug delivery systems. To that end, we assessed the possible interaction between PHA nanoparticles (NPs) and pulmonary surfactant using dynamic light scattering, Langmuir balances, and epifluorescence microscopy. Our results demonstrate that NPs deposited onto preformed monolayers of DPPC or DPPC/POPG bind these surfactant lipids. This interaction facilitated the translocation of the nanomaterial towards the aqueous subphase, with the subsequent loss of lipid from the interface. NPs that remained at the interface associated with liquid expanded (LE)/tilted condensed (TC) phase boundaries, decreasing the size of condensed domains and promoting the intermixing of TC and LE phases at submicroscopic scale. This provided the stability necessary for attaining high surface pressures upon compression, countering the destabilization induced by lipid loss. These effects were observed only for high NP loads, suggesting a limit for the use of these NPs in pulmonary drug delivery.


Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1347
Author(s):  
Arbanah Muhammad ◽  
Dabin Lee ◽  
Yonghun Shin ◽  
Juhyun Park

Porous polysaccharides have recently attracted attention due to their porosity, abundance, and excellent properties such as sustainability and biocompatibility, thereby resulting in their numerous applications. Recent years have seen a rise in the number of studies on the utilization of polysaccharides such as cellulose, chitosan, chitin, and starch as aerogels due to their unique performance for the fabrication of porous structures. The present review explores recent progress in porous polysaccharides, particularly cellulose and chitosan, including their synthesis, application, and future outlook. Since the synthetic process is an important aspect of aerogel formation, particularly during the drying step, the process is reviewed in some detail, and a comparison is drawn between the supercritical CO2 and freeze drying processes in order to understand the aerogel formation of porous polysaccharides. Finally, the current applications of polysaccharide aerogels in drug delivery, wastewater, wound dressing, and air filtration are explored, and the limitations and outlook of the porous aerogels are discussed with respect to their future commercialization.


2021 ◽  
Vol 26 (5) ◽  
pp. 509-521
Author(s):  
Tamara Athamneh ◽  
Adil Amin ◽  
Edit Benke ◽  
Rita Ambrus ◽  
Pavel Gurikov ◽  
...  

2021 ◽  
Vol 126 ◽  
pp. 112117
Author(s):  
Maria Nikolaou ◽  
Kyriakos Avraam ◽  
Argiris Kolokithas-Ntoukas ◽  
Aristides Bakandritsos ◽  
Frantisek Lizal ◽  
...  

2019 ◽  
Vol 150 ◽  
pp. 49-55 ◽  
Author(s):  
Tamara Athamneh ◽  
Adil Amin ◽  
Edit Benke ◽  
Rita Ambrus ◽  
Claudia S. Leopold ◽  
...  

2015 ◽  
Vol 85 ◽  
pp. 83-99 ◽  
Author(s):  
Qi (Tony) Zhou ◽  
Sharon Shui Yee Leung ◽  
Patricia Tang ◽  
Thaigarajan Parumasivam ◽  
Zhi Hui Loh ◽  
...  

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