Trabecular micro-bypass stent implantation during small-incision cataract surgery for open-angle glaucoma or ocular hypertension: Long-term results

Purpose. To evaluate the long-term efficacy and safety of the iStentinjectdevice (Glaukos Corporation, Laguna Hills, CA) combined with phacoemulsification in patients with coexistent cataract and open-angle glaucoma or ocular hypertension (OHT).Methods. A prospective, uncontrolled, nonrandomized, interventional case series study was conducted in patients with both mild or moderate open-angle glaucoma or OHT and cataract. Patients underwent cataract surgery along with the implant of two iStentinjectdevices. Outcome measures were intraocular pressure (IOP), topical hypotensive medications required, and best-corrected visual acuity (BCVA).Results. 20 patients were enrolled. Mean follow-up was47.4±18.46months. Mean baseline IOP was19.95±3.71 mmHg with medication and26±3.11 mmHg after washout. Mean end-follow-up IOP was16.25±1.99 mmHg, representing an IOP decrease of 36.92%,9.74±3.14 mmHg (P<0.001), from baseline washout IOP. The mean number of medications was significantly reduced from1.3±0.66to0.75±0.79(P=0.017). 45% of patients were medication-free by the end of follow-up. Meanlog⁡MARBCVA improved significantly from0.42±0.16to0.18±0.16(P<0.001). No complications of surgery were observed.Conclusion. The iStentinjectdevice combined with cataract surgery served to significantly reduce both IOP and medication use in the long term in patients with coexistent open-angle glaucoma or ocular hypertension (OHT) and cataract.

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Long-term Outcomes of Combined Cataract Surgery and Trabeculotomy using Trabectome for Coexisting Cataract and Open-angle Glaucoma: A 5 Year Follow-Up

Journal of Clinical & Experimental Ophthalmology ◽

10.4172/2155-9570.1000757 ◽

2018 ◽

Vol 09 (05) ◽

Author(s):

Arezoo Miraftabi ◽

Seyed Javad Hashemian ◽

Leila Sasani ◽

Mohammad Ebrahim Jafari ◽

Mahsa Hashemian

Keyword(s):

Cataract Surgery ◽

Open Angle Glaucoma ◽

Open Angle ◽

Long Term Outcomes

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Phase III safety and efficacy study of long-term brinzolamide/timolol fixed combination in Japanese patients with open-angle glaucoma or ocular hypertension

Clinical Ophthalmology ◽

10.2147/opth.s55456 ◽

2013 ◽

pp. 149

Author(s):

Masayuki Nakajima ◽

Naoki Iwasaki ◽

Masaki Adachi

Keyword(s):

Ocular Hypertension ◽

Fixed Combination ◽

Open Angle Glaucoma ◽

Japanese Patients ◽

Phase Iii ◽

Efficacy Study ◽

Open Angle ◽

Safety And Efficacy

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A comparative study of combined small-incision cataract surgery with sutureless trabeculectomy versus trabeculectomy using W-shaped incision

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v3i1.4272 ◽

1970 ◽

Vol 3 (1) ◽

pp. 13-18 ◽

Cited By ~ 2

Author(s):

AK Khurana ◽

U Chawla ◽

N Passi ◽

A Jyoti ◽

A Archana ◽

...

Keyword(s):

Cataract Surgery ◽

Open Angle Glaucoma ◽

Posterior Chamber ◽

Combined Surgery ◽

Small Incision Cataract Surgery ◽

Small Incision ◽

Group A ◽

The Mean ◽

Incision Technique ◽

Group B

Introduction: Manual small-incision cataract surgery with trabeculectomy is now an acceptable option in the surgical management of combined cataract and glaucoma uncontrolled with maximum tolerated medical therapy. Objective: To compare the results and complications of combined manual small-incision cataract surgery (SICS) and posterior chamber intraocular lens (PCIOL) implantation with trabeculectomy by sutureless versus W-shaped incision technique. Materials and methods: The study included 30 eyes of 28 patients with senile cataract and primary open-angle glaucoma (POAG) who were randomly divided into two groups. The patients in Group A (n = 15) underwent SICS with sutureless trabeculectomy and those in Group B (n =15) underwent SICS with trabeculectomy using W-shaped incision with one suture. Post-operative evaluation was done at the first post-operative day and thereafter on follow-ups at 1 week, 2 weeks, 4 weeks and 8 weeks. Results: The mean preoperative and postoperative intraocular pressure (IOP) in Group A was 27.33 ± 3.35 mmHg and 16.13 ± 4.30 mmHg respectively and in Group B it was 29.46 ± 6.06 mmHg and 14.66 ± 2.69 mmHg respectively. The mean reduction in IOP after 8 weeks of follow-up in Group A was 12.52 ± 3.59 mmHg and that in Group B was 16.47 ± 3.79 mmHg (p <0.001). Besides this, the uncorrected visual acuity (UCVA) was better in Group B postoperatively with less surgically-induced against-the-rule (ATR) astigmatism. Conclusion: Combined SICS with trabeculectomy using W-shaped incision offers better prospective in terms of glaucoma control and visual performance than sutureless combined surgery. Key words: sutureless trabeculectomy; combined surgery; W-shaped trabeculectomyDOI: 10.3126/nepjoph.v3i1.4272Nepal J Ophthalmol 2011;3(5):13-18

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