Topical drug delivery to the posterior segment of the eye: Dexamethasone concentrations in various eye tissues after topical administration for up to 15 days to rabbits

2018 ◽  
Vol 45 ◽  
pp. 449-454 ◽  
Author(s):  
Sunna Johannsdottir ◽  
Phatsawee Jansook ◽  
Einar Stefansson ◽  
Iris Myrdal Kristinsdottir ◽  
Zoltan Fulop ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Topical Administration ◽  
Posterior Segment ◽  
Topical Drug Delivery ◽  
Eye Tissues

scholarly journals Posterior Segment Ophthalmic Drug Delivery: Role of Muco-Adhesion with a Special Focus on Chitosan

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1685
Author(s):  
Ayah Mohammad Burhan ◽  
Butsabarat Klahan ◽  
Wayne Cummins ◽  
Vanessa Andrés-Guerrero ◽  
Mark E. Byrne ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
Special Focus ◽  
Topical Drug Delivery ◽  
Ophthalmic Drug Delivery ◽  
Mucoadhesive Polymers ◽  
Eye Tissues ◽  
Successful Design ◽  
Ophthalmic Drug

Posterior segment eye diseases (PSEDs) including age macular degeneration (AMD) and diabetic retinopathy (DR) are amongst the major causes of irreversible blindness worldwide. Due to the numerous barriers encountered, highly invasive intravitreal (IVT) injections represent the primary route to deliver drugs to the posterior eye tissues. Thus, the potential of a more patient friendly topical route has been widely investigated. Mucoadhesive formulations can decrease precorneal clearance while prolonging precorneal residence. Thus, they are expected to enhance the chances of adherence to corneal and conjunctival surfaces and as such, enable increased delivery to the posterior eye segment. Among the mucoadhesive polymers available, chitosan is the most widely explored due to its outstanding mucoadhesive characteristics. In this review, the major PSEDs, their treatments, barriers to topical delivery, and routes of topical drug absorption to the posterior eye are presented. To enable the successful design of mucoadhesive ophthalmic drug delivery systems (DDSs), an overview of mucoadhesion, its theory, characterization, and considerations for ocular mucoadhesion is given. Furthermore, chitosan-based DDs that have been explored to promote topical drug delivery to the posterior eye segment are reviewed. Finally, challenges of successful preclinical to clinical translation of these DDSs for posterior eye drug delivery are discussed.

scholarly journals Topical Drug Delivery to the Posterior Segment of the Eye

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 134
Author(s):  
Marina Löscher ◽  
Chiara Seiz ◽  
José Hurst ◽  
Sven Schnichels
Keyword(s):  
Drug Delivery ◽  
Animal Models ◽  
Treatment Option ◽  
Topical Treatment ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
Posterior Segment ◽  
Retinal Diseases ◽  
Topical Drug Delivery ◽  
Ocular Pharmacokinetics

Topical drug delivery to the posterior segment of the eye is a very complex challenge. However, topical delivery is highly desired, to achieve an easy-to-use treatment option for retinal diseases. In this review, we focus on the drug characteristics that are relevant to succeed in this challenge. An overview on the ocular barriers that need to be overcome and some relevant animal models to study ocular pharmacokinetics are given. Furthermore, a summary of substances that were able to reach the posterior segment after eye drop application is provided, as well as an outline of investigated delivery systems to improve ocular drug delivery. Some promising results of substances delivered to the retina suggest that topical treatment of retinal diseases might be possible in the future, which warrants further research.

Recent advance of nanoparticle-based topical drug delivery to the posterior segment of the eye

2018 ◽  
Vol 15 (7) ◽  
pp. 687-701 ◽  
Author(s):  
Yanyan Wang ◽  
Xiaoyue Xu ◽  
Yan Gu ◽  
Yanju Cheng ◽  
Feng Cao
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
Topical Drug Delivery

Hydrogel Ring for Topical Drug Delivery to the Ocular Posterior Segment

2015 ◽  
Vol 41 (5) ◽  
pp. 653-661 ◽  
Author(s):  
Yuko Shikamura ◽  
Yoshiko Yamazaki ◽  
Toru Matsunaga ◽  
Takao Sato ◽  
Akira Ohtori ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
Topical Drug Delivery

Topical drug delivery to the posterior segment of the eye: The effect of benzalkonium chloride on topical dexamethasone penetration into the eye in vivo

2018 ◽  
Vol 48 ◽  
pp. 125-127 ◽  
Author(s):  
Sunna Johannsdottir ◽  
Phatsawee Jansook ◽  
Einar Stefansson ◽  
Iris Myrdal Kristinsdottir ◽  
Gudrun Marta Asgrimsdottir ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Benzalkonium Chloride ◽  
Posterior Segment ◽  
Topical Drug Delivery

scholarly journals Topical Drug Delivery to the Posterior Segment of the Eye: Addressing the Challenge of Preclinical to Clinical Translation

2018 ◽  
Vol 35 (12) ◽  
Author(s):  
Gerard A. Rodrigues ◽  
David Lutz ◽  
Jie Shen ◽  
Xiaoda Yuan ◽  
Hong Shen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
Clinical Translation ◽  
Topical Drug Delivery

scholarly journals Penetration Enhancers for Topical Drug Delivery to the Ocular Posterior Segment—A Systematic Review

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 276
Author(s):  
Abhinav Thareja ◽  
Helen Hughes ◽  
Carmen Alvarez-Lorenzo ◽  
Jenni J. Hakkarainen ◽  
Zubair Ahmed
Keyword(s):  
Drug Delivery ◽  
Experimental Studies ◽  
Topical Administration ◽  
Cell Penetrating Peptides ◽  
Posterior Segment ◽  
Penetration Enhancer ◽  
Penetration Enhancers ◽  
Qualitative Synthesis ◽  
Ocular Penetration ◽  
Ovid Medline

There is an unmet clinical need for eye drop formulations to efficiently treat the diseases of the posterior ocular segment by non-invasive topical administration. Here, we systematically reviewed the literature on ocular penetration enhancers and their ability to transfer drugs to the posterior segment of the eye in experimental studies. Our aim was to assess which penetration enhancer is the most efficient at delivering drugs to the posterior segment of the eye, when topically applied. We conducted a comprehensive search in three electronic databases (Ovid Embase, Ovid MEDLINE, and PubMed) to identify all the relevant manuscripts reported on ocular penetration enhancers based on the PRISMA guidelines. We identified 6540 records from our primary database search and filtered them per our inclusion/exclusion criteria to select a final list of 14 articles for qualitative synthesis. Of these, 11 studies used cell penetrating peptides (CPPs), 2 used chitosan, and 1 used benzalkonium chloride (BAC) as the penetration enhancer. Cationic and amphipathic CPPs, transactivator of transcription (TAT), and penetratin can be inferred to be the best among all the identified penetration enhancers for drug delivery to the fundus oculi via topical eye drop instillation. Further high-quality experimental studies are required to ascertain their quantitative efficacy.

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