Connexin43 Mimetic Peptide-Loaded Light Responsive In Situ Forming Injectable Implants for Effective Drug Delivery to the Posterior Segment of the Eye

2016 ◽  
Author(s):  
Rohit Bisht
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
Effective Drug ◽  
Mimetic Peptide ◽  
In Situ Forming

Light-responsive in situ forming injectable implants for effective drug delivery to the posterior segment of the eye

2016 ◽  
Vol 13 (7) ◽  
pp. 953-962 ◽  
Author(s):  
Rohit Bisht ◽  
Jagdish Kumar Jaiswal ◽  
Ying-Shan Chen ◽  
Jianyong Jin ◽  
Ilva Dana Rupenthal
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
Effective Drug ◽  
In Situ Forming

In Vitro and In Vivo Drug Release from a Novel In Situ Forming Drug Delivery System

2007 ◽  
Vol 25 (6) ◽  
pp. 1347-1354 ◽  
Author(s):  
Heiko Kranz ◽  
Erol Yilmaz ◽  
Gayle A. Brazeau ◽  
Roland Bodmeier
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Situ Forming

scholarly journals In-vivo Evaluation and Characterization of Novel In-Situ Gelling System as Controlled Delivery System Containing Ciprofloxacin for Ocular Drug Delivery

2020 ◽  
Vol 10 (5-s) ◽  
pp. 32-39
Author(s):  
Fatima Eram ◽  
, Vivek
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Average Concentration ◽  
Posterior Segment ◽  
Ocular Infection ◽  
In Vivo Evaluation ◽  
Micro Emulsion ◽  
In Situ Gelling

Objectives: The purpose of this research was to develop the micro emulsion-based in situ gelling systems containing Ciprofloxacin for prophylaxis and treatment of the posterior segment diseases like endophthalmitis. Methods: Ciprofloxacin was encapsulated in small droplets owing to form microemulsion, and then the formed droplets were dispersed in a polymer solution that converted into a gel upon triggered by the electrolyte present in the tear fluid. Results: The formulation approach provides better absorption, penetration, retention, and improves the bioavailability of the drug. The average concentration reached into vitreous humor from topical microemulsion in situ gelling formulation was ~0.4 µg/ml, which is far more than the concentration required for therapeutic effect (i.e.  >0.047 µg/ml or >MIC90 for S. Epidermidis, a pathogen commonly responsible to cause endophthalmitis). Conclusion: Thus, novel micro emulsion-based in situ gelling formulation could be a potential drug delivery system for the treatment of posterior segment diseases like endophthalmitis. Keywords: Microemulsion, ciprofloxacin, endophthalmitis, ocular, infection, in situ

Injectable,in situ forming poly(propylene fumarate)-based ocular drug delivery systems

2007 ◽  
Vol 83A (3) ◽  
pp. 656-666 ◽  
Author(s):  
H. Ueda ◽  
M.C. Hacker ◽  
A. Haesslein ◽  
S. Jo ◽  
D.M. Ammon ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
In Situ Forming ◽  
Poly Propylene
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