Printing of cutaneous patches loaded with propranolol for the treatment of infantile haemangiomas

Author(s):  
Umberto M. Musazzi ◽  
Chiara G.M. Gennari ◽  
Silvia Franzè ◽  
Paola Minghetti ◽  
Francesco Cilurzo
2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Amr Abdelhamid AbouZeid ◽  
Iman A. Ragab ◽  
Shaimaa Abdelsattar Mohammad ◽  
Wael Ahmed Ghanem ◽  
Haytham Mohamed Nasser ◽  
...  

Abstract Background Infantile haemangiomas (IH) represent a common benign vascular tumour affecting the paediatric population. Infantile haemangiomas are characterised by a natural history differentiating it from other vascular anomalies. After a transient proliferative phase in early infancy, the tumour passes through a plateau phase before going into spontaneous involution. In this report, we tried to share our experience over the last 5 years in managing cases presenting with IH at a specialised vascular anomaly clinic. Main body of abstract This report included cases of IH who were attending the vascular anomaly clinic during the period 2015 through 2019. Data of all patients attending the clinic were retrospectively examined. Files of 103 cases with IH were available for review. The diagnosis of IH was usually straight forward owing to the typical history and characteristic findings at clinical examination. A significant female predominance was noticed. Generally, IH were more common in the head and neck region (70%). Active intervention was necessary in specific situations (eye occlusion, airway involvement, large lesions with skin ulcerations). Whenever intervention proved to be necessary, propranolol was chosen as the first line of treatment with a favourable response detected in about 90% of cases. Surgery was still a valid option (6%) for lesions amenable to resection; however, we must put in consideration that most lesions will spontaneously regress. Conclusion Infantile haemangiomas are common benign vascular tumours of infancy with relatively few complications. Cosmesis is a major concern especially for lesions affecting the face. Propranolol can induce tumour regression in most cases, and generally, a favourable outcome can be anticipated.


2013 ◽  
Vol 66 (12) ◽  
pp. 1732-1740 ◽  
Author(s):  
M. de Graaf ◽  
M.F. Raphael ◽  
C.C. Breugem ◽  
M.J. Knol ◽  
C.A.F.M. Bruijnzeel-Koomen ◽  
...  

2016 ◽  
pp. 69-78
Author(s):  
Sherief R. Janmohamed ◽  
Nisha Suyien Chandran ◽  
Arnold P. Oranje

2019 ◽  
Vol 12 (2) ◽  
pp. e226929
Author(s):  
Taha Anwar ◽  
Elizabeth Malm-Buatsi

Infantile haemangiomas are one of the most common tumours in infancy, but typically present as cutaneous lesions; haemangiomas of the urinary bladder are incredibly rare. Although benign, these can sometimes ulcerate and bleed, causing haematuria in the case of bladder lesions. Propranolol is a well-documented medical therapy for cutaneous lesions, but surgical treatment dominates the literature on bladder haemangiomas. We present the case of a child with infantile haemangiomas of the urinary bladder, as well as internal and cutaneous lesions, treated with propranolol. At 6-week follow-up cystoscopy and MRI, there was a significant improvement in both bladder and internal lesions, respectively. Follow-up with dermatology 9 months after initiation of propranolol demonstrated excellent regression of the cutaneous lesions with a marked decrease in both size and prominence. This case demonstrates the potential role of propranolol in the treatment of bladder haemangiomas in lieu of more invasive surgical techniques.


2013 ◽  
Vol 169 (1) ◽  
pp. 181-183 ◽  
Author(s):  
C. Léauté-Labrèze ◽  
E. Dumas de la Roque ◽  
F. Nacka ◽  
A. Abouelfath ◽  
N. Grenier ◽  
...  

Author(s):  
Anna L. Bruckner ◽  
Ilona J. Frieden ◽  
Julie Powell

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