Preparation of copper oxide nanoparticles coated with bovine serum albumin for delivery of methotrexate

2021 ◽  
pp. 103015
Author(s):  
Zahra Mohammadhassan ◽  
Ramin Mohammadkhani ◽  
Ali Mohammadi ◽  
Kasra Arbabi Zaboli ◽  
Saeed Kaboli ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Copper Oxide ◽  
Bovine Serum ◽  
Copper Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals The Bovine Serum Albumin Coated Copper Oxide Nanoparticle for Curcumin Delivery in Biological Environment: In-vitro Drug Release

2021 ◽  
Author(s):  
Tahmineh Atloo ◽  
Ramin Mohammadkhani ◽  
Ali Mohammadi ◽  
Kasra Arbabi Zaboli ◽  
Saeed Kaboli ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Copper Oxide ◽  
Cell Line ◽  
Bovine Serum ◽  
Copper Oxide Nanoparticles ◽  
Buffer Solution ◽  
Biological Environment

Abstract In this work, first, copper oxide nanoparticles (CUO NPs) were synthesized by physical methods and then coated with the bovine serum albumin (BSA) via biologically meditated minerals to form CUO@BSA NPs. Finally, curcumin (CUR) as an anticancer drug were immobilized on the surface of CUO@BSA NPS. The properties of CUO@BSA-CUR NPS were investigated by FTIR, UV-Vis, TEM, and AFM spectroscopes. It was found that the synthesized CUO@BSA-CUR nanoparticles were spherical with a particle size of 20 to 30 nm and have a sustained release of CUR at 37°C in buffer solution. Also, the result of release in biological environment showed that maximum drug release rate for this nanocarrier in pH 7.4 was measured 75% after 48 hours. The cytotoxicity of CUO@BSA-CUR on MDA-MB-231 cell line was studied. The results showed that CUO@BSA-CUR nanoparticles have significant cytotoxic activity on this cell line, while the results of MTT assay indicated the CUO@BSA NPs have no toxicity effect on the cancer cells.

scholarly journals Effects of humic acid and bovine serum albumin on the agglomeration and sedimentation of oxide nanoparticles

2014 ◽  
Vol 15 (8) ◽  
pp. 643-652 ◽  
Author(s):  
Fan-bao Hu ◽  
Yong-feng Lin ◽  
Ru Chen ◽  
Lei Ding ◽  
Wei Jiang
Keyword(s):  
Humic Acid ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Oxide Nanoparticles

IMMOBILIZATION OF BSA ON DENDRIMER FUNCTIONALIZED MAGNETIC NANOPARTICLES

2011 ◽  
Vol 10 (04n05) ◽  
pp. 919-923 ◽  
Author(s):  
S. CHANDRA ◽  
N. NITHYAMATHI ◽  
P. SELVAMANI ◽  
D. BAHADUR
Keyword(s):  
Particle Size ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Ftir Spectroscopy ◽  
Magnetite Nanoparticles ◽  
Bovine Serum ◽  
Oxide Nanoparticles ◽  
Functionalized Magnetic Nanoparticles

Iron oxide nanoparticles were prepared and functionalized by succinamide based dendrimer. The resultant particles were characterized by XRD, VSM, and FTIR spectroscopy. The results indicate that the dendrimers has effectively functionalized the magnetite nanoparticles which remain dispersive and exhibited super-paramagnetism with a magnetization value of 33.2 emu/g in a field of 2T. Mean particle size as calculated from the AFM was found to be ~ 23 nm. Bovine serum albumin was immobilized on the magnetic nanoparticles as was confirmed by the FTIR results.

Fluorescence study of bovine serum albumin and Ti and Sn oxide nanoparticles interactions

2007 ◽  
Author(s):  
Denisio M. Togashi ◽  
Alan G. Ryder ◽  
Deirdre Mc Mahon ◽  
Peter Dunne ◽  
James McManus
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Oxide Nanoparticles ◽  
Fluorescence Study
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