Autologous platelet-rich plasma treatment for patients with diabetic foot ulcers: a meta-analysis of randomized studies

Introduction and Aim: This study has been undertaken to evaluate efficacy of platelet rich plasma (PRP) dressing that is recently introduced with conventional dressing. We have tried to compare PRP dressing with conventional normal dressing in healing the wound. Materials and Methods: We conducted this study in 120 patients of chronic non healing diabetic foot ulcers who were treated over the period of three years. Number of cases (60 each) were studied for efficacy of applying autologous platelet rich plasma versus normal dressing for chronic non healing diabetic foot ulcers. At every week follow up, the ulcer was examined for granulation tissue, area and volume which was calculated using Vernier calipers and marked on a graph paper and photographs were taken. Wound healing was compared between PRP and normal dressing. Results: The incidence of male susceptibility was more (70%) than females (30%) in diabetic foot. Average rate of healing per week was found to be significantly better among the PRP group than normal dressing group. The ulcer showed significant reduction in size among the PRP group in comparison to the normal dressing group with a significant P value (0.001). Conclusion: In this study application of platelet rich plasma into chronic non-healing diabetic foot ulcers in comparison with conventional dressing has shown a significant reduction in the size of the ulcer, hospital stay and cost for the patient.

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Autologous Platelet-Rich Plasma Treatment Enables Pregnancy for a Woman in Premature Menopause

Journal of Clinical Medicine ◽

10.3390/jcm8010001 ◽

2018 ◽

Vol 8 (1) ◽

pp. 1 ◽

Cited By ~ 10

Author(s):

Konstantinos Sfakianoudis ◽

Mara Simopoulou ◽

Nikolaos Nitsos ◽

Anna Rapani ◽

Athanasios Pappas ◽

...

Keyword(s):

In Vitro Fertilization ◽

Plasma Treatment ◽

Platelet Rich Plasma ◽

Ovarian Tissue ◽

Medical Knowledge ◽

Premature Menopause ◽

Vitro Fertilization ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet

This report presents the case of a woman aged 40 who has experienced premature menopause from the age of 35. Having rejected oocyte donation, she opted for intraovarian injection of autologous platelet-rich plasma with the aim to rejuvenate the ovarian tissue and enable the employment of her own gametes through in-vitro fertilization. Six weeks following the autologous platelet-rich plasma treatment, a significant reduction in the patient’s follicle-stimulating hormone (FSH) levels were noted. A natural in-vitro fertilization cycle led to a biochemical pregnancy, resulting in a spontaneous abortion at the 5th week of pregnancy. This is the first report of a successful autologous platelet-rich plasma application leading to pregnancy in menopause. This report uniquely contributes to the medical knowledge and challenges current practice in the context of infertility. The efficiency and safety of this treatment with regard to the reproductive system merits further investigation.

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