In order to assess the feasibility of emergency department (ED) physician screening of patients with minor injuries for alcohol problems, a two-part screening process was implemented in an urban ED. Blood alcohol concentration was measured using either a saliva strip or a serum alcohol test. Questions about alcohol use frequency, and consumption quantity were asked in addition to the CAGE questions. Over a one-year period 2,439 adults (age ≥ 18 years) with non-life-threatening injuries were screened. Multiple strategies were used in order to increase compliance over the course of the study. Over the first six months, the overall screening rate increased from 8% to 45% and remained level for most of the duration of the project. Individual variations in rates ranged from 5% to 70%. Screening for alcohol problems is feasible in the ED setting and may be integrated as part of the role of the ED physician.